Human Gene AGPAT1 (uc011hcs.2) Description and Page Index
  Description: Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase 1 (AGPAT1), transcript variant 2, mRNA.
RefSeq Summary (NM_032741): This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:3,478,807-3,488,712 Size: 9,906 Total Exon Count: 7 Strand: -
Coding Region
   Position: chr6_mann_hap4:3,479,877-3,482,097 Size: 2,221 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: AGPAT1
CDC HuGE Published Literature: AGPAT1
Positive Disease Associations: Diabetes Mellitus, Type 1 , Macular Degeneration , Phospholipids , Psoriasis
Related Studies:
  1. Diabetes Mellitus, Type 1
    , , . [PubMed 0]
  2. Macular Degeneration
    , , . [PubMed 0]
  3. Macular Degeneration
    , , . [PubMed 0]
  4. Macular Degeneration
    , , . [PubMed 0]
  5. Macular Degeneration
    , , . [PubMed 0]
  6. Macular Degeneration
    , , . [PubMed 0]
  7. Macular Degeneration
    , , . [PubMed 0]
  8. Macular Degeneration
    , , . [PubMed 0]
  9. Phospholipids
    Ayse Demirkan et al. PLoS genetics 2012, Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations., PLoS genetics. [PubMed 22359512]
  10. Psoriasis
    , , . [PubMed 0]

+  Comparative Toxicogenomics Database (CTD)
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-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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+  mRNA Secondary Structure of 3' and 5' UTRs
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+  Protein Domain and Structure Information
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+  Orthologous Genes in Other Species
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-  Descriptions from all associated GenBank mRNAs
  AB209572 - Homo sapiens mRNA for palmitoyl-protein thioesterase 2 isoform c precursor variant protein.
BC004310 - Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha), mRNA (cDNA clone MGC:10915 IMAGE:3627439), complete cds.
BC006818 - Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha), mRNA (cDNA clone IMAGE:3448169).
AF007145 - Homo sapiens clone 23552 unknown mRNA, partial cds.
AK129818 - Homo sapiens cDNA FLJ26307 fis, clone DMC08287, highly similar to 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (EC 2.3.1.51).
Y09565 - H.sapiens mRNA for 1-acylglycerol-3-phosphate O-acyltransferase.
BC090849 - Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha), mRNA (cDNA clone MGC:102686 IMAGE:6169543), complete cds.
BC002402 - Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha), mRNA (cDNA clone MGC:8511 IMAGE:2822348), complete cds.
BC003007 - Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha), mRNA (cDNA clone MGC:4007 IMAGE:2822348), complete cds.
AK058025 - Homo sapiens cDNA FLJ25296 fis, clone STM07640, highly similar to 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE ALPHA (EC 2.3.1.51).
U56417 - Human lysophosphatidic acid acyltransferase-alpha mRNA, complete cds.
U75971 - Homo sapiens putative lysophospholipid acyltransferase mRNA, complete cds.
AF218034 - Homo sapiens clone PP931 unknown mRNA.
AK056346 - Homo sapiens cDNA FLJ31784 fis, clone NT2RI2008481, highly similar to 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (EC 2.3.1.51).
AK299252 - Homo sapiens cDNA FLJ54610 complete cds, highly similar to 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (EC 2.3.1.51).
AK315950 - Homo sapiens cDNA, FLJ78849 complete cds, highly similar to 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (EC 2.3.1.51).

+  Biochemical and Signaling Pathways
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+  Other Names for This Gene
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+  Gene Model Information
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-  Methods, Credits, and Use Restrictions
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