Human Gene AGPAT1 (uc011hcs.2) Description and Page Index
  Description: Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase 1 (AGPAT1), transcript variant 2, mRNA.
RefSeq Summary (NM_032741): This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:3,478,807-3,488,712 Size: 9,906 Total Exon Count: 7 Strand: -
Coding Region
   Position: chr6_mann_hap4:3,479,877-3,482,097 Size: 2,221 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

+  Comments and Description Text from UniProtKB
  Press "+" in the title bar above to open this section.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: AGPAT1
CDC HuGE Published Literature: AGPAT1
Positive Disease Associations: Diabetes Mellitus, Type 1 , Macular Degeneration , Phospholipids , Psoriasis
Related Studies:
  1. Diabetes Mellitus, Type 1
    , , . [PubMed 0]
  2. Macular Degeneration
    , , . [PubMed 0]
  3. Macular Degeneration
    , , . [PubMed 0]
  4. Macular Degeneration
    , , . [PubMed 0]
  5. Macular Degeneration
    , , . [PubMed 0]
  6. Macular Degeneration
    , , . [PubMed 0]
  7. Macular Degeneration
    , , . [PubMed 0]
  8. Macular Degeneration
    , , . [PubMed 0]
  9. Phospholipids
    Ayse Demirkan et al. PLoS genetics 2012, Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations., PLoS genetics. [PubMed 22359512]
  10. Psoriasis
    , , . [PubMed 0]

+  Comparative Toxicogenomics Database (CTD)
  Press "+" in the title bar above to open this section.

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
Ratios
      
      
      
     
    
     
Absolute
      
       
      
      
     
    
Ratios
      
       
      
      
     
    
Absolute
   
     
     
Ratios
   
     
     
Absolute

GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
Ratios
      
    
     
      
    
    
Absolute
      
      
      
Ratios
      
      
      
Absolute

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -31.20120-0.260 Picture PostScript Text
3' UTR -383.791070-0.359 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

+  Protein Domain and Structure Information
  Press "+" in the title bar above to open this section.

+  Orthologous Genes in Other Species
  Press "+" in the title bar above to open this section.

+  Descriptions from all associated GenBank mRNAs
  Press "+" in the title bar above to open this section.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00561 - Glycerolipid metabolism
hsa00564 - Glycerophospholipid metabolism
hsa01100 - Metabolic pathways

-  Other Names for This Gene
  Alternate Gene Symbols: A2BFI5, G15, NM_032741, NP_116130, PLCA_HUMAN, Q5BL03, Q99943
UCSC ID: uc011hcs.2
RefSeq Accession: NM_032741
Protein: Q99943 (aka PLCA_HUMAN