Human Gene AGPAT1 (uc011hcs.2) Description and Page Index
Description: Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase 1 (AGPAT1), transcript variant 2, mRNA. RefSeq Summary (NM_032741): This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: chr6_mann_hap4:3,478,807-3,488,712 Size: 9,906 Total Exon Count: 7 Strand: - Coding Region Position: chr6_mann_hap4:3,479,877-3,482,097 Size: 2,221 Coding Exon Count: 6
Phospholipids Ayse Demirkan et al. PLoS genetics 2012, Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations., PLoS genetics.
[PubMed 22359512]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
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Orthologous Genes in Other Species
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Descriptions from all associated GenBank mRNAs
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Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00561 - Glycerolipid metabolism hsa00564 - Glycerophospholipid metabolism hsa01100 - Metabolic pathways
