Human Gene PPT2 (uc011hci.2) Description and Page Index
  Description: Homo sapiens palmitoyl-protein thioesterase 2 (PPT2), transcript variant 3, mRNA.
RefSeq Summary (NM_001204103): This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene. [provided by RefSeq, Feb 2011].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:3,464,620-3,474,285 Size: 9,666 Total Exon Count: 9 Strand: +
Coding Region
   Position: chr6_mann_hap4:3,465,216-3,473,554 Size: 8,339 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: PPT2
CDC HuGE Published Literature: PPT2
Positive Disease Associations: Diabetes Mellitus, Type 1
Related Studies:
  1. Diabetes Mellitus, Type 1
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
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GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -165.43404-0.409 Picture PostScript Text
3' UTR -246.77731-0.338 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

+  Protein Domain and Structure Information
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+  Orthologous Genes in Other Species
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-  Descriptions from all associated GenBank mRNAs
  AK307427 - Homo sapiens cDNA, FLJ97375.
AL110128 - Homo sapiens mRNA; cDNA DKFZp564P1516 (from clone DKFZp564P1516).
AF020544 - Homo sapiens inactive palmitoyl-protein thioesterase-2i (PPT2) mRNA, complete cds.
AF020543 - Homo sapiens palmitoyl-protein thioesterase-2 (PPT2) mRNA, complete cds.
AK296648 - Homo sapiens cDNA FLJ52513 complete cds, highly similar to Lysosomal thioesterase PPT2 precursor (EC 3.1.2.-).
Y17958 - Homo sapiens mRNA for palmitoyl protein thioesterase 2.
AK290473 - Homo sapiens cDNA FLJ78536 complete cds, highly similar to Homo sapiens inactive palmitoyl-protein thioesterase-2i (PPT2) mRNA.
BC001355 - Homo sapiens palmitoyl-protein thioesterase 2, mRNA (cDNA clone MGC:1313 IMAGE:3050231), complete cds.
BC000955 - Homo sapiens cDNA clone IMAGE:3450442, containing frame-shift errors.
AK292729 - Homo sapiens cDNA FLJ75166 complete cds, highly similar to Homo sapiens palmitoyl-protein thioesterase 2 (PPT2), transcriptvariant 3, mRNA.
AM392834 - Synthetic construct Homo sapiens clone IMAGE:100001744 for hypothetical protein (PPT2 gene).
CR533546 - Homo sapiens full open reading frame cDNA clone RZPDo834H0819D for gene PPT2, palmitoyl-protein thioesterase 2; complete cds, incl. stopcodon.
EU832418 - Synthetic construct Homo sapiens clone HAIB:100067447; DKFZo004F0728 palmitoyl-protein thioesterase 2 protein (PPT2) gene, encodes complete protein.
EU832333 - Synthetic construct Homo sapiens clone HAIB:100067362; DKFZo008F0727 palmitoyl-protein thioesterase 2 protein (PPT2) gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00062 - Fatty acid elongation in mitochondria
hsa01100 - Metabolic pathways
hsa04142 - Lysosome

-  Other Names for This Gene
  Alternate Gene Symbols: A2ABC9, A2ABD1, A2ARM7, A2BFH7, A2BFH9, A2BFI2, A8K9L4, B0S868, NM_001204103, NP_005146, O14799, PPT2_HUMAN, Q0P6K0, Q5JP13, Q5JP14, Q5JQF0, Q5SSX4, Q5SSX5, Q5SSX6, Q5STJ4, Q5STJ5, Q5STJ6, Q6FI80, Q99945, Q9UMR5
UCSC ID: uc011hci.2
RefSeq Accession: NM_001204103
Protein: Q9UMR5 (aka PPT2_HUMAN