Human Gene P2RY4 (uc004dxz.1) Description and Page Index
  Description: Homo sapiens pyrimidinergic receptor P2Y, G-protein coupled, 4 (P2RY4), mRNA.
RefSeq Summary (NM_002565): The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Transcript (Including UTRs)
   Position: chrX:69,478,016-69,479,654 Size: 1,639 Total Exon Count: 1 Strand: -
Coding Region
   Position: chrX:69,478,377-69,479,474 Size: 1,098 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=P2Y purinoceptor 4; Short=P2Y4; AltName: Full=P2P; AltName: Full=Uridine nucleotide receptor; Short=UNR;
FUNCTION: Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
PTM: Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Common Gene Haplotype Alleles
Generated from 1000 Genomes Phase1 variants (help).
Restricted to 6 non-synonymous, common variant sites with a frequency of occurrence of at least 1%.
All variations and sequence reflect the negative ('-' or "reverse") strand.
HaplotypeHomozygous Variant Sites
Freq %Freq %RefVNSIWP
17.611.5 V T AIWP
8.505.59 V TSIWP
4.642.56  M TSIWP
3.681.74 V TS VW T
1.020.27 V T AI ]

Common gene alleles shown: 6

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -72.90180-0.405 Picture PostScript Text
3' UTR -114.00361-0.316 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

+  Protein Domain and Structure Information
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+  Orthologous Genes in Other Species
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+  Descriptions from all associated GenBank mRNAs
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-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

+  Other Names for This Gene
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-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_002565.3
exon count: 1CDS single in 3' UTR: no RNA size: 1639
ORF size: 1098CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2296.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

+  Methods, Credits, and Use Restrictions
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