Human Gene MICB (uc011gxf.2) Description and Page Index
  Description: Homo sapiens MHC class I polypeptide-related sequence B (MICB), mRNA.
RefSeq Summary (NM_005931): This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,717,805-2,821,820 Size: 104,016 Total Exon Count: 6 Strand: +
Coding Region
   Position: chr6_mann_hap4:2,717,844-2,820,607 Size: 102,764 Coding Exon Count: 6 

Page IndexSequence and LinksGenetic AssociationsCTDMicroarrayRNA Structure
Other SpeciesmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: MICB
CDC HuGE Published Literature: MICB
Positive Disease Associations: Behcet Syndrome , Dengue Hemorrhagic Fever , Diabetes Mellitus, Type 1 , Multiple Sclerosis , Neuroblastoma , Neutrophils , psoriasis , Respiratory Function Tests , rheumatoid arthritis , schizophrenia , Triglycerides , ulcerative colitis
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  3. Dengue Hemorrhagic Fever
    Chiea Chuen Khor et al. Nature genetics 2011, Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1., Nature genetics. [PubMed 22001756]
           more ... click here to view the complete list

+  Comparative Toxicogenomics Database (CTD)
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-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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+  mRNA Secondary Structure of 3' and 5' UTRs
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+  Orthologous Genes in Other Species
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+  Descriptions from all associated GenBank mRNAs
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+  Biochemical and Signaling Pathways
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-  Other Names for This Gene
  Alternate Gene Symbols: B0S8B5, B0S8B5_HUMAN, DAMA-25N12.5-001, NM_005931, NP_005922, X91625
UCSC ID: uc011gxf.2
RefSeq Accession: NM_005931

+  Gene Model Information
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+  Methods, Credits, and Use Restrictions
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