Human Gene TRIM31 (uc011grq.2) Description and Page Index
Description: Homo sapiens tripartite motif containing 31 (TRIM31), mRNA. RefSeq Summary (NM_007028): The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to both the cytoplasm and the nucleus. Its function has not been identified. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF230386.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025083, ERS025084 [ECO:0000350] ##Evidence-Data-END## Transcript (Including UTRs) Position: chr6_mann_hap4:1,369,234-1,379,420 Size: 10,187 Total Exon Count: 9 Strand: - Coding Region Position: chr6_mann_hap4:1,369,873-1,379,135 Size: 9,263 Coding Exon Count: 8
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Comments and Description Text from UniProtKB
ID:TRI31_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase TRIM31; EC=6.3.2.-; AltName: Full=Tripartite motif-containing protein 31; FUNCTION: Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with isoform p52shc of SHC1 (By similarity). May form oligomers. SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria. TISSUE SPECIFICITY: Up-regulated in gastric adenocarcinomas. PTM: Auto-ubiquitinated (in vitro). SIMILARITY: Belongs to the TRIM/RBCC family. SIMILARITY: Contains 1 B box-type zinc finger. SIMILARITY: Contains 1 RING-type zinc finger. SEQUENCE CAUTION: Sequence=AAH16866.1; Type=Erroneous initiation;
Genetic Association Studies of Complex Diseases and Disorders
Behcet Syndrome Elaine F Remmers et al. Nature genetics 2010, , Nature genetics.
Cardiomegaly Afshin Parsa et al. Clinical and translational science 2011, Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality., Clinical and translational science.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BZY9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.