Human Gene HLA-DPA1 (uc021zqp.1) Description and Page Index
  Description: Homo sapiens major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1), transcript variant 2, mRNA.
RefSeq Summary (NM_001242524): HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:4,489,886-4,506,101 Size: 16,216 Total Exon Count: 6 Strand: -
Coding Region
   Position: chr6_mann_hap4:4,493,967-4,498,887 Size: 4,921 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: HLA-DPA1
CDC HuGE Published Literature: HLA-DPA1
Positive Disease Associations: Asthma , cardiomyopathy , cholestasis , Hepatitis B, Chronic , HIV Infections|HIV Seropositivity , Scleroderma, Systemic
Related Studies:
  1. Asthma
    Emiko Noguchi et al. PLoS genetics 2011, Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations., PLoS genetics. [PubMed 21814517]
  2. cardiomyopathy
    Liu, W. et al. 2006, Association of HLA class II DRB1, DPA1 and DPB1 polymorphism with genetic susceptibility to idiopathic dilated cardiomyopathy in Chinese Han nationality, Autoimmunity 2006 39(6) 461-7. [PubMed 17060025]
  3. cholestasis
    Zhang, L. et al. 2003, [Human leucocyte antigen-DPA1 polymorphism distribution in Chengdu Chinese families with intrahepatic cholestasis of pregnancy], Sichuan da xue xue bao Yi xue ban. 2003 Jul;34(3):530-2. [PubMed 12910711]
    It is unlikely that an HLA-DPA1 allele is primarily associated with susceptibility or resistance to ICP.
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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -52.20198-0.264 Picture PostScript Text
3' UTR -221.90791-0.281 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

+  Protein Domain and Structure Information
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+  Orthologous Genes in Other Species
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-  Descriptions from all associated GenBank mRNAs
  X00457 - Human mRNA for SB classII histocompatibility antigen alpha-chain.
AB209058 - Homo sapiens mRNA for HLA-DPA1 protein variant protein.
BC009956 - Homo sapiens major histocompatibility complex, class II, DP alpha 1, mRNA (cDNA clone MGC:14114 IMAGE:4309471), complete cds.
AK292709 - Homo sapiens cDNA FLJ75222 complete cds, highly similar to Homo sapiens major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1), mRNA.
M27487 - Homo sapiens MHC class II DPw3-alpha-1 chain mRNA, complete cds.
CU679537 - Synthetic construct Homo sapiens gateway clone IMAGE:100018648 5' read HLA-DPA1 mRNA.
DQ893463 - Synthetic construct clone IMAGE:100006093; FLH193286.01X; RZPDo839E0878D major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1) gene, encodes complete protein.
DQ896324 - Synthetic construct Homo sapiens clone IMAGE:100010784; FLH193282.01L; RZPDo839E0868D major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1) gene, encodes complete protein.
AB590198 - Synthetic construct DNA, clone: pFN21AE1515, Homo sapiens HLA-DPA1 gene for major histocompatibility complex, class II, DP alpha 1, without stop codon, in Flexi system.
CU680547 - Synthetic construct Homo sapiens gateway clone IMAGE:100023440 3' read HLA-DPB1 mRNA.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04514 - Cell adhesion molecules (CAMs)
hsa04612 - Antigen processing and presentation
hsa04672 - Intestinal immune network for IgA production
hsa04940 - Type I diabetes mellitus
hsa05140 - Leishmaniasis
hsa05310 - Asthma
hsa05320 - Autoimmune thyroid disease
hsa05322 - Systemic lupus erythematosus
hsa05330 - Allograft rejection
hsa05332 - Graft-versus-host disease
hsa05416 - Viral myocarditis

+  Other Names for This Gene
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+  Gene Model Information
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+  Methods, Credits, and Use Restrictions
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