Human Gene HLA-DRB1 (uc021zqg.1) Description and Page Index
Description: Synthetic construct DNA, clone: pF1KB6349, Homo sapiens HLA-DRB1 gene for major histocompatibility complex, class II, DR beta 1, without stop codon, in Flexi system. Transcript (Including UTRs) Position: chr6_mann_hap4:3,952,727-3,952,941 Size: 215 Total Exon Count: 1 Strand: -
Chen-Chung Chu , et al. Transfusion 2009 49(3):472-8, Anti-"Mi(a)" immunization is associated with HLA-DRB1*0901., Transfusion 2009 49(3):472-8.
Addison's disease Park, Y. S. et al. 2002, Additional association of intra-MHC genes, MICA and D6S273, with Addison's disease, Tissue antigens. 2002 Aug;60(2):155-63.
Susceptibility to Addison's disease is influenced by the genes around MICA and D6S273 for both the HLA DR3-DQ2 and DR4-DQ8 haplotypes.
allergy Suzuki, K. et al. 2005, HLA class II DPB1, DQA1, DQB1, and DRB1 genotypic associations with occupational allergic cough to Bunashimeji mushroom., Tissue antigens. 2005 May;65(5):459-66.
The HLA-DRB1*0803 allele alone, the DRB1*0803, DQA1*0103, DQB1*0601 haplotype, or both were negatively associated with allergy to Bunashimeji, and these alleles might be involved in the prevention of Bunashimeji mushroom-specific respiratory allergy.
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
AF017439 - Homo sapiens MHC class II antigen (HLA-DRB1) mRNA, partial cds. KJ534866 - Homo sapiens clone HLA-DRB1_iso-A_fetal-F07 MHC class II antigen (HLA-DRB1) mRNA, partial cds, alternatively spliced.