Human Gene HLA-DRB1 (uc021zqg.1) Description and Page Index
  Description: Synthetic construct DNA, clone: pF1KB6349, Homo sapiens HLA-DRB1 gene for major histocompatibility complex, class II, DR beta 1, without stop codon, in Flexi system.
Transcript (Including UTRs)
   Position: chr6_mann_hap4:3,952,727-3,952,941 Size: 215 Total Exon Count: 1 Strand: -


Page IndexSequence and LinksGenetic AssociationsCTDOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: HLA-DRB1
CDC HuGE Published Literature: HLA-DRB1
Positive Disease Associations: , Addison's disease , allergy , alpha 1-antitrypsin deficiency , alveolar echinococcosis , Alzheimer's Disease , Anemia, Sickle Cell|Lung Diseases|Syndrome , antineutrophil cytoplasmic antibody; (ANCA)-associated vasculitis , aortoarteritis , Arthritis (juvenile idiopathic) , arthritis, rheumatoid , Arthritis, Rheumatoid|Rheumatoid Arthritis , Arthritis, Rheumatoid|Sjogren's Syndrome , asthma , asthma; urticaria , atopy , autism , autoimmune thyroid disease; thyroid disease, autoimmune , autologous mixed lymphocyte reaction , azoospermia , birth weight body mass , breast cancer , cardiomyopathy , celiac disease , cervical cancer , cholangitis, sclerosing , Cholesterol , cirrhosis, biliary primary , coronary artery ectasia , Crohn's disease , delayed sleep phase syndrome. , diabetes mellitus , Diabetes Mellitus, Type 1 , diabetes, type 1 , diabetes, type 1; Addison's disease , diabetes, type 1; blood group incompatibility , diabetes, type 2 , endometriosis , epilepsy , gastric adenocarcinoma , giant cell arteritis , Glomerulonephritis, IGA , Graves disease , Graves' disease , hepatitis B, chronic , hepatitis type 2, autoimmune , hepatitis, autoimmune , human papillomavirus infection , hypertension , hypertension, pulmonary arterial , hypothyroidism, goitrous juvenile autoimmune , immune response to hepatitis B vaccine , Immunoglobulin A , increased prevalence and level of insulin autoantibodies , Inflammatory Bowel Diseases , Leprosy , leukemia , Leukemia, Lymphoid , liver disease , lupus erythematosus , Lupus Erythematosus, Systemic , lupus erythematosus; nephropathy in other diseases , lymphoma , microscopic polyangiitis , Mite-sensitive asthma , Multiple Myeloma , multiple sclerosis , myasthenia gravis , narcolepsy , Nasopharyngeal Neoplasms , ocular cicatricial pemphigoid , pancreatitis, autoimmune , pancreatitis, autoimmune; pancreatitis, chronic calcifying , pemphigus foliaceus , periodontitis , pollen allergy , Polyendocrinopathies, Autoimmune , posttreatment Th2 immune response to S. mansoni Ags , pre-eclampsia , preeclampsia , pregnancy loss, recurrent , psoriasis , psoriatic arthritis , pulmonary tuberculosis , recurrent oral ulcers , recurrent respiratory papillomatosis , renal disease, end stage , response to ximelagatran treatment , rheumatic heart disease , rheumatoid arthritis , rhinitis , sarcoidosis , schizophrenia , Scleroderma, Systemic , sclerosis, systemic , sickle cell anemia , Sjogren's syndrome , SLE , SPT (cockroach) , SPT (HDM) , systemic lupus erythematosus , Takayasu arteritis , thryoiditis, chronic lymphocytic , thyroid carcinoma , thyroiditis, Hashimoto's , tuberculosis , type 1 diabetes , ulcerative colitis , viral clearance , vitiligo , Vogt-Koyanagi-Harada syndrome , Vogt-Koyanagi-Harada's disease , X-linked adrenoleukodystrophy
Related Studies:

  1. Chen-Chung Chu , et al. Transfusion 2009 49(3):472-8, Anti-"Mi(a)" immunization is associated with HLA-DRB1*0901., Transfusion 2009 49(3):472-8. [PubMed 19243543]
  2. Addison's disease
    Park, Y. S. et al. 2002, Additional association of intra-MHC genes, MICA and D6S273, with Addison's disease, Tissue antigens. 2002 Aug;60(2):155-63. [PubMed 12392510]
    Susceptibility to Addison's disease is influenced by the genes around MICA and D6S273 for both the HLA DR3-DQ2 and DR4-DQ8 haplotypes.
  3. allergy
    Suzuki, K. et al. 2005, HLA class II DPB1, DQA1, DQB1, and DRB1 genotypic associations with occupational allergic cough to Bunashimeji mushroom., Tissue antigens. 2005 May;65(5):459-66. [PubMed 15853900]
    The HLA-DRB1*0803 allele alone, the DRB1*0803, DQA1*0103, DQB1*0601 haplotype, or both were negatively associated with allergy to Bunashimeji, and these alleles might be involved in the prevention of Bunashimeji mushroom-specific respiratory allergy.
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AF017439 - Homo sapiens MHC class II antigen (HLA-DRB1) mRNA, partial cds.
KJ534866 - Homo sapiens clone HLA-DRB1_iso-A_fetal-F07 MHC class II antigen (HLA-DRB1) mRNA, partial cds, alternatively spliced.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_bbcellPathway - Bystander B Cell Activation
h_tcraPathway - Lck and Fyn tyrosine kinases in initiation of TCR Activation
h_ctla4Pathway - The Co-Stimulatory Signal During T-cell Activation
h_inflamPathway - Cytokines and Inflammatory Response
h_CSKPathway - Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor
h_il5Pathway - IL 5 Signaling Pathway
h_th1th2Pathway - Th1/Th2 Differentiation
h_asbcellPathway - Antigen Dependent B Cell Activation
h_blymphocytePathway - B Lymphocyte Cell Surface Molecules
h_eosinophilsPathway - The Role of Eosinophils in the Chemokine Network of Allergy
h_mhcPathway - Antigen Processing and Presentation

-  Other Names for This Gene
  Alternate Gene Symbols: AF017439
UCSC ID: uc021zqg.1
Representative RNA: AF017439

-  Gene Model Information
 
category: noncoding nonsense-mediated-decay: no RNA accession: AF017439.1
exon count: 1CDS single in 3' UTR: no RNA size: 330
ORF size: 0CDS single in intron: no Alignment % ID: 95.95
txCdsPredict score: 242.00frame shift in genome: no % Coverage: 64.55
has start codon: no stop codon in genome: no # of Alignments: 7
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.