Human Gene GPANK1 (uc021zpk.1) Description and Page Index
  Description: Homo sapiens G patch domain and ankyrin repeats 1 (GPANK1), transcript variant 5, mRNA.
RefSeq Summary (NM_001199240): This gene is located in a cluster of HLA-B-associated transcripts, which is included in the human major histocompatability complex III region. This gene encodes a protein which is thought to play a role in immunity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2010].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,971,896-2,976,297 Size: 4,402 Total Exon Count: 4 Strand: -
Coding Region
   Position: chr6_mann_hap4:2,972,933-2,975,145 Size: 2,213 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
  ID: GPAN1_HUMAN
DESCRIPTION: RecName: Full=G patch domain and ankyrin repeat-containing protein 1; AltName: Full=Ankyrin repeat domain-containing protein 59; AltName: Full=G patch domain-containing protein 10; AltName: Full=HLA-B-associated transcript 4; AltName: Full=Protein G5;
SIMILARITY: Contains 2 ANK repeats.
SIMILARITY: Contains 1 G-patch domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -115.75337-0.343 Picture PostScript Text
3' UTR -338.161037-0.326 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom
IPR000467 - G_patch_dom

Pfam Domains:
PF01585 - G-patch domain

SCOP Domains:
48403 - Ankyrin repeat

ModBase Predicted Comparative 3D Structure on O95872
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Jackson Lab     
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  AK123707 - Homo sapiens cDNA FLJ41713 fis, clone HLUNG2011833, highly similar to Homo sapiens MSH55 gene.
AJ420471 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1089917.
BC008783 - Homo sapiens HLA-B associated transcript 4, mRNA (cDNA clone MGC:3737 IMAGE:3629572), complete cds.
BC018875 - Homo sapiens HLA-B associated transcript 4, mRNA (cDNA clone IMAGE:3629069).
AK314056 - Homo sapiens cDNA, FLJ94721, highly similar to Homo sapiens HLA-B associated transcript 4 (BAT4), mRNA.
DQ892676 - Synthetic construct clone IMAGE:100005306; FLH188762.01X; RZPDo839F1073D HLA-B associated transcript 4 (BAT4) gene, encodes complete protein.
DQ895918 - Synthetic construct Homo sapiens clone IMAGE:100010378; FLH188758.01L; RZPDo839F1063D HLA-B associated transcript 4 (BAT4) gene, encodes complete protein.
AB529099 - Synthetic construct DNA, clone: pF1KB4392, Homo sapiens BAT4 gene for HLA-B associated transcript 4, without stop codon, in Flexi system.
AF087962 - Homo sapiens full length insert cDNA clone YU40C12.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NG25, ANKRD59, B0UXA2, BAT4, G5, GPAN1_HUMAN, GPATCH10, NM_001199240, NP_149417, O95872, Q5SQ49
UCSC ID: uc021zpk.1
RefSeq Accession: NM_001199240
Protein: O95872 (aka GPAN1_HUMAN