Human Gene SLC39A7 (uc011hgw.2) Description and Page Index
Description: Homo sapiens solute carrier family 39 (zinc transporter), member 7 (SLC39A7), transcript variant 1, mRNA. RefSeq Summary (NM_006979): The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. Transcript (Including UTRs) Position: chr6_mann_hap4:4,625,919-4,629,530 Size: 3,612 Total Exon Count: 7 Strand: + Coding Region Position: chr6_mann_hap4:4,626,339-4,628,906 Size: 2,568 Coding Exon Count: 7
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Comments and Description Text from UniProtKB
ID:S39A7_HUMAN DESCRIPTION: RecName: Full=Zinc transporter SLC39A7; AltName: Full=Histidine-rich membrane protein Ke4; AltName: Full=Really interesting new gene 5 protein; AltName: Full=Solute carrier family 39 member 7; AltName: Full=Zrt-, Irt-like protein 7; Short=ZIP7; FUNCTION: Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+). INTERACTION: P68400:CSNK2A1; NbExp=4; IntAct=EBI-1051105, EBI-347804; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane. TISSUE SPECIFICITY: Widely expressed. INDUCTION: Down-regulated by Zn(+2). PTM: Rapidly phosphorylated by CK2 following Zn(2+) treatment. This phosphorylation is required for efficient cytosolic Zn(2+) release. SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database: SLC39A7 CDC HuGE Published Literature: SLC39A7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92504
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.