Human Gene SLC39A7 (uc011hgw.2) Description and Page Index
  Description: Homo sapiens solute carrier family 39 (zinc transporter), member 7 (SLC39A7), transcript variant 1, mRNA.
RefSeq Summary (NM_006979): The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:4,625,919-4,629,530 Size: 3,612 Total Exon Count: 7 Strand: +
Coding Region
   Position: chr6_mann_hap4:4,626,339-4,628,906 Size: 2,568 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Comments and Description Text from UniProtKB
  ID: S39A7_HUMAN
DESCRIPTION: RecName: Full=Zinc transporter SLC39A7; AltName: Full=Histidine-rich membrane protein Ke4; AltName: Full=Really interesting new gene 5 protein; AltName: Full=Solute carrier family 39 member 7; AltName: Full=Zrt-, Irt-like protein 7; Short=ZIP7;
FUNCTION: Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+).
INTERACTION: P68400:CSNK2A1; NbExp=4; IntAct=EBI-1051105, EBI-347804;
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane.
TISSUE SPECIFICITY: Widely expressed.
INDUCTION: Down-regulated by Zn(+2).
PTM: Rapidly phosphorylated by CK2 following Zn(2+) treatment. This phosphorylation is required for efficient cytosolic Zn(2+) release.
SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: SLC39A7
CDC HuGE Published Literature: SLC39A7

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -144.01420-0.343 Picture PostScript Text
3' UTR -253.70624-0.407 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003689 - ZIP

Pfam Domains:
PF02535 - ZIP Zinc transporter

ModBase Predicted Comparative 3D Structure on Q92504
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  AK303158 - Homo sapiens cDNA FLJ52943 complete cds, highly similar to Zinc transporter SLC39A7.
AK301126 - Homo sapiens cDNA FLJ54178 complete cds, highly similar to Zinc transporter SLC39A7.
BC000645 - Homo sapiens solute carrier family 39 (zinc transporter), member 7, mRNA (cDNA clone MGC:1928 IMAGE:3345970), complete cds.
AK225282 - Homo sapiens mRNA for Zinc transporter SLC39A7 variant, clone: HEP00938.
AK225682 - Homo sapiens mRNA for Zinc transporter SLC39A7 variant, clone: SYN03265.
D82060 - Homo sapiens mRNA for membrane protein with histidine rich charge clusters, complete cds.
CU674314 - Synthetic construct Homo sapiens gateway clone IMAGE:100018323 5' read SLC39A7 mRNA.
AB590119 - Synthetic construct DNA, clone: pFN21AE1327, Homo sapiens SLC39A7 gene for solute carrier family 39 (zinc transporter), member 7, without stop codon, in Flexi system.
DQ891929 - Synthetic construct clone IMAGE:100004559; FLH181512.01X; RZPDo839E03136D solute carrier family 39 (zinc transporter), member 7 (SLC39A7) gene, encodes complete protein.
DQ895116 - Synthetic construct Homo sapiens clone IMAGE:100009576; FLH181508.01L; RZPDo839E03135D solute carrier family 39 (zinc transporter), member 7 (SLC39A7) gene, encodes complete protein.
M58660 - Human MHC HLA-D region non-class II protein (RING5) mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: B0UXF6, HKE4, NM_006979, NP_008910, Q5STP8, Q92504, Q9UIQ0, RING5, S39A7_HUMAN
UCSC ID: uc011hgw.2
RefSeq Accession: NM_006979
Protein: Q92504 (aka S39A7_HUMAN