Human Gene RXRB (uc011hgo.3) Description and Page Index
Description: Homo sapiens retinoid X receptor, beta (RXRB), transcript variant 1, mRNA. RefSeq Summary (NM_001270401): This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]. Transcript (Including UTRs) Position: chr6_mann_hap4:4,618,677-4,625,789 Size: 7,113 Total Exon Count: 10 Strand: - Coding Region Position: chr6_mann_hap4:4,619,775-4,625,569 Size: 5,795 Coding Exon Count: 10
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Comments and Description Text from UniProtKB
ID:RXRB_HUMAN DESCRIPTION: RecName: Full=Retinoic acid receptor RXR-beta; AltName: Full=Nuclear receptor subfamily 2 group B member 2; AltName: Full=Retinoid X receptor beta; FUNCTION: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Specifically binds 9-cis retinoic acid (9C-RA). SUBUNIT: Homodimer (By similarity). Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. INTERACTION: Q00975:CACNA1B; NbExp=3; IntAct=EBI-748576, EBI-1055161; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in a variety of tumor cell lines. DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. SIMILARITY: Belongs to the nuclear hormone receptor family. NR2 subfamily. SIMILARITY: Contains 1 nuclear receptor DNA-binding domain. SEQUENCE CAUTION: Sequence=BAD92481.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Genetic Association Studies of Complex Diseases and Disorders
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P28702
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
X63523 - H.sapiens mRNA DAUDI6 3'-region. BC001167 - Homo sapiens retinoid X receptor, beta, mRNA (cDNA clone MGC:1831 IMAGE:3502936), complete cds. X65463 - H.sapiens mRNA for MHC class I promoter binding protein. X63522 - H.sapiens mRNA DAUDI6 for retinoic acid X receptor b. AK225842 - Homo sapiens mRNA for retinoid X receptor, beta variant, clone: FCC126E12. AK302125 - Homo sapiens cDNA FLJ61673 complete cds, highly similar to Retinoic acid receptor RXR-beta. AB209244 - Homo sapiens mRNA for retinoid X receptor, beta variant protein. M84820 - Human retinoid X receptor beta (RXR-beta) mRNA, complete cds. BT007280 - Homo sapiens retinoid X receptor, beta mRNA, complete cds. AB384890 - Synthetic construct DNA, clone: pF1KB4058, Homo sapiens RXRB gene for retinoic acid receptor RXR-beta, complete cds, without stop codon, in Flexi system. AK301096 - Homo sapiens cDNA FLJ50703 complete cds, highly similar to Retinoic acid receptor RXR-beta. X66424 - H.sapiens mRNA for retinoid X receptor b, exons a and b. AK295759 - Homo sapiens cDNA FLJ50538 complete cds, highly similar to Retinoic acid receptor RXR-beta. AK300402 - Homo sapiens cDNA FLJ61401 complete cds, highly similar to Retinoic acid receptor RXR-beta. HQ692844 - Homo sapiens retinoid X nuclear receptor beta (NR2B2) mRNA, complete cds. HQ709179 - Homo sapiens retinoid X nuclear receptor beta (NR2B2) mRNA, complete cds.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03320 - PPAR signaling pathway hsa04920 - Adipocytokine signaling pathway hsa05200 - Pathways in cancer hsa05216 - Thyroid cancer hsa05222 - Small cell lung cancer hsa05223 - Non-small cell lung cancer