Human Gene RXRB (uc011hgo.3) Description and Page Index
  Description: Homo sapiens retinoid X receptor, beta (RXRB), transcript variant 1, mRNA.
RefSeq Summary (NM_001270401): This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:4,618,677-4,625,789 Size: 7,113 Total Exon Count: 10 Strand: -
Coding Region
   Position: chr6_mann_hap4:4,619,775-4,625,569 Size: 5,795 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

+  Comments and Description Text from UniProtKB
  Press "+" in the title bar above to open this section.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: RXRB
CDC HuGE Published Literature: RXRB
Positive Disease Associations: Cholesterol, LDL , Creatinine , schizophrenia
Related Studies:
  1. Cholesterol, LDL
    Cristen J Willer et al. Nature genetics 2008, Newly identified loci that influence lipid concentrations and risk of coronary artery disease., Nature genetics. [PubMed 18193043]
  2. Creatinine
    , , . [PubMed 0]
  3. Creatinine
    , , . [PubMed 0]
           more ... click here to view the complete list

+  Comparative Toxicogenomics Database (CTD)
  Press "+" in the title bar above to open this section.

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
Ratios
      
      
      
     
    
     
Absolute
      
       
      
      
     
    
Ratios
      
       
      
      
     
    
Absolute
   
     
     
Ratios
   
     
     
Absolute

GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
Ratios
      
    
     
      
    
    
Absolute
      
      
      
Ratios
      
      
      
Absolute

+  mRNA Secondary Structure of 3' and 5' UTRs
  Press "+" in the title bar above to open this section.

+  Protein Domain and Structure Information
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  X63523 - H.sapiens mRNA DAUDI6 3'-region.
BC001167 - Homo sapiens retinoid X receptor, beta, mRNA (cDNA clone MGC:1831 IMAGE:3502936), complete cds.
X65463 - H.sapiens mRNA for MHC class I promoter binding protein.
X63522 - H.sapiens mRNA DAUDI6 for retinoic acid X receptor b.
AK225842 - Homo sapiens mRNA for retinoid X receptor, beta variant, clone: FCC126E12.
AK302125 - Homo sapiens cDNA FLJ61673 complete cds, highly similar to Retinoic acid receptor RXR-beta.
AB209244 - Homo sapiens mRNA for retinoid X receptor, beta variant protein.
M84820 - Human retinoid X receptor beta (RXR-beta) mRNA, complete cds.
BT007280 - Homo sapiens retinoid X receptor, beta mRNA, complete cds.
AB384890 - Synthetic construct DNA, clone: pF1KB4058, Homo sapiens RXRB gene for retinoic acid receptor RXR-beta, complete cds, without stop codon, in Flexi system.
AK301096 - Homo sapiens cDNA FLJ50703 complete cds, highly similar to Retinoic acid receptor RXR-beta.
X66424 - H.sapiens mRNA for retinoid X receptor b, exons a and b.
AK295759 - Homo sapiens cDNA FLJ50538 complete cds, highly similar to Retinoic acid receptor RXR-beta.
AK300402 - Homo sapiens cDNA FLJ61401 complete cds, highly similar to Retinoic acid receptor RXR-beta.
HQ692844 - Homo sapiens retinoid X nuclear receptor beta (NR2B2) mRNA, complete cds.
HQ709179 - Homo sapiens retinoid X nuclear receptor beta (NR2B2) mRNA, complete cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03320 - PPAR signaling pathway
hsa04920 - Adipocytokine signaling pathway
hsa05200 - Pathways in cancer
hsa05216 - Thyroid cancer
hsa05222 - Small cell lung cancer
hsa05223 - Non-small cell lung cancer

+  Other Names for This Gene
  Press "+" in the title bar above to open this section.

+  Gene Model Information
  Press "+" in the title bar above to open this section.

+  Methods, Credits, and Use Restrictions
  Press "+" in the title bar above to open this section.