Human Gene BRD2 (uc011hfs.2) Description and Page Index
  Description: Homo sapiens bromodomain containing 2 (BRD2), transcript variant 2, mRNA.
RefSeq Summary (NM_001113182): This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:4,395,892-4,403,388 Size: 7,497 Total Exon Count: 10 Strand: +


Page IndexSequence and LinksGenetic AssociationsCTDMicroarrayOther Species
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: BRD2
CDC HuGE Published Literature: BRD2
Positive Disease Associations: Asthma , Heart Rate , photoparoxysmal response , Triglycerides
Related Studies:
  1. Asthma
    Tomomitsu Hirota et al. Nature genetics 2011, Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population., Nature genetics. [PubMed 21804548]
  2. Heart Rate
    , , . [PubMed 0]
  3. photoparoxysmal response
    Lorenz, S. et al. 2006, Association of BRD2 polymorphisms with photoparoxysmal response, Neurosci Lett 2006. [PubMed 16516380]
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+  Comparative Toxicogenomics Database (CTD)
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-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  D42040 - Homo sapiens KIAA9001 mRNA, complete cds.
AK309797 - Homo sapiens cDNA, FLJ99838.
BX648109 - Homo sapiens mRNA; cDNA DKFZp686E1432 (from clone DKFZp686E1432).
AK056504 - Homo sapiens cDNA FLJ31942 fis, clone NT2RP7006717, highly similar to Mus musculus Ring3 mRNA.
AL832722 - Homo sapiens mRNA; cDNA DKFZp313H139 (from clone DKFZp313H139).
M80613 - Human homolog of Drosophila female sterile homeotic mRNA, complete cds.
X62083 - H.sapiens mRNA for Drosophila female sterile homeotic (FSH) homologue.
BC007715 - Homo sapiens bromodomain containing 2, mRNA (cDNA clone IMAGE:4302993), partial cds.
BC001885 - Homo sapiens bromodomain containing 2, mRNA (cDNA clone IMAGE:3544244), with apparent retained intron.
BC000477 - Homo sapiens bromodomain containing 2, mRNA (cDNA clone IMAGE:2961647).
BC063840 - Homo sapiens bromodomain containing 2, mRNA (cDNA clone MGC:74927 IMAGE:6181728), complete cds.
AB384868 - Synthetic construct DNA, clone: pF1KB3863, Homo sapiens BRD2 gene for bromodomain-containing protein 2, complete cds, without stop codon, in Flexi system.
S78771 - NAT=CpG island-associated gene [human, mRNA, 1741 nt].
BX647233 - Homo sapiens mRNA; cDNA DKFZp686N0336 (from clone DKFZp686N0336).
AK024312 - Homo sapiens cDNA FLJ14250 fis, clone OVARC1001244, highly similar to H.sapiens mRNA for Drosophila female sterile homeotic (FSH) homologue.

+  Other Names for This Gene
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+  Gene Model Information
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+  Methods, Credits, and Use Restrictions
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