Human Gene HLA-DMB (uc011hfl.2) Description and Page Index
  Description: Homo sapiens major histocompatibility complex, class II, DM beta (HLA-DMB), mRNA.
RefSeq Summary (NM_002118): HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U15085.1, AY645722.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084, ERS025087 [ECO:0000348] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: chr6_mann_hap4:4,359,617-4,362,444 Size: 2,828 Total Exon Count: 2 Strand: -
Coding Region
   Position: chr6_mann_hap4:4,359,959-4,362,388 Size: 2,430 Coding Exon Count: 2 

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Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr6_mann_hap4:4,359,617-4,362,444)mRNA (may differ from genome)Protein (81 aa)
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