Human Gene PSMB9 (uc011hfe.2) Description and Page Index
  Description: Homo sapiens proteasome (prosome, macropain) subunit, beta type, 9 (PSMB9), mRNA.
RefSeq Summary (NM_002800): The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. [provided by RefSeq, Mar 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ706947.1, BQ947748.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: chr6_mann_hap4:4,279,134-4,284,825 Size: 5,692 Total Exon Count: 6 Strand: +
Coding Region
   Position: chr6_mann_hap4:4,279,203-4,284,506 Size: 5,304 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: PSMB9
CDC HuGE Published Literature: PSMB9
Positive Disease Associations: diabetes, type 1 , Forced Vital Capacity , Graves disease , malaria; hypoglycemia; hyperparasitemia , Myocardial Infarction , psoriasis
Related Studies:
  1. diabetes, type 1
    Kawaguchi Y et al. 1994, Absence of association of TAP and LMP genes with type 1 (insulin-dependent) diabetes mellitus., Life sciences. 1994 ;54(26):2049-53. [PubMed 7911550]
  2. Forced Vital Capacity
    , , . [PubMed 0]
  3. Graves disease
    Heward JM et al. 1999, Association of the large multifunctional proteasome (LMP2) gene with Graves' disease is a result of linkage disequilibrium with the HLA haplotype DRB1*0304-DQB1*02-DQA1*0501., Clinical endocrinology. 1999 Jul;51(1):115-8. [PubMed 10468973]
    These results show that association of the LMP 2 locus with Graves' disease is due to linkage disequilibrium with the associated HLA haplotype DRB1*0304-DQB1*02-DQA1*0501.
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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D000082 Acetaminophen
  • D013749 Tetrachlorodibenzodioxin
  • D014635 Valproic Acid
  • D002737 Chloroprene
  • D004051 Diethylhexyl Phthalate
  • C017947 sodium arsenite
  • C032668 1-nitropyrene
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
  • C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -23.3069-0.338 Picture PostScript Text
3' UTR -80.73319-0.253 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

+  Protein Domain and Structure Information
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+  Orthologous Genes in Other Species
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-  Descriptions from all associated GenBank mRNAs
  BX641100 - Homo sapiens mRNA; cDNA DKFZp686G10229 (from clone DKFZp686G10229).
AK303118 - Homo sapiens cDNA FLJ54210 complete cds, moderately similar to Proteasome subunit beta type 9 precursor (EC 3.4.25.1).
BC008795 - Homo sapiens cDNA clone IMAGE:3626111, **** WARNING: chimeric clone ****.
BC018885 - Homo sapiens cDNA clone IMAGE:3626664, **** WARNING: chimeric clone ****.
BC065513 - Homo sapiens proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2), mRNA (cDNA clone MGC:70470 IMAGE:5749985), complete cds.
X62741 - H.sapiens RING12 mRNA.
S75169 - LMP2=proteasome LMP2.s {alternatively spliced} [human, EBV-transformed B lymphoblastoid typing cell lines, mRNA, 645 nt].
U01025 - Human proteasome-related (LMP-2) mRNA, complete cds.
AB528725 - Synthetic construct DNA, clone: pF1KB6989, Homo sapiens PSMB9 gene for proteasome (prosome, macropain) subunit, beta type, 9, without stop codon, in Flexi system.
CR541656 - Homo sapiens full open reading frame cDNA clone RZPDo834B0927D for gene PSMB9, proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional protease 2); complete cds, without stopcodon.
CU688056 - Synthetic construct Homo sapiens gateway clone IMAGE:100023193 5' read PSMB9 mRNA.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03050 - Proteasome

BioCarta from NCI Cancer Genome Anatomy Project
h_mhcPathway - Antigen Processing and Presentation

+  Other Names for This Gene
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+  Gene Model Information
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+  Methods, Credits, and Use Restrictions
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