Human Gene HLA-DQB1 (uc011her.2) Description and Page Index
  Description: Homo sapiens major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1), transcript variant 3, mRNA.
Transcript (Including UTRs)
   Position: chr6_mann_hap4:4,084,784-4,090,096 Size: 5,313 Total Exon Count: 3 Strand: -
Coding Region
   Position: chr6_mann_hap4:4,084,976-4,090,052 Size: 5,077 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesGeneReviews
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: HLA-DQB1
CDC HuGE Published Literature: HLA-DQB1
Positive Disease Associations: Addison's disease , allergic rhinitis , allergy , allergy, latex; latex allergy , Alopecia Areata , Anemia, Sickle Cell|Lung Diseases|Syndrome , Arthritis, Rheumatoid , asthma , asthma; urticaria , autoimmune response , azoospermia , breast cancer , Carcinoma, Hepatocellular , cardiac sarcoidosis , cataract glaucoma retinal detachment visual acuity Vogt-Koyanagi-Harada syndrome , celiac disease , cervical cancer , cervical dysplasia H. pylori infection , cholangitis, sclerosing , cirrhosis, biliary primary , clinical tuberculosis , Coronary Artery Disease , coronary artery ectasia , Crohn Disease , dermatomyositis/ polymyositis , Diabetes Mellitus, Type 1 , diabetes, type 1 , diabetes, type 1 diabetes, type 2 , diabetes, type 1; Addison's disease , diabetes, type 1; celiac disease , diabetes, type 2 , diabetes, type 2; diabetes, type 1 , diabetes-associated autoantibodies , Diabetic Nephropathies , drug hypersensitivity; asthma; rhinosinuitis, allergic fungal; sinusitis , Drug-Induced Liver Injury , gastric adenocarcinoma , glomerulonephritis, Hepatitis B virus-associated , Glomerulonephritis, IGA , glutamic acid decarboxylase antibodies , Graves Disease , Graves' disease , H. pylori infection , H. pylori infection stomach cancer , hepatitis B, chronic , hepatitis type 2, autoimmune , HIV , HIV Infections|Tuberculosis, Pulmonary , human papillomavirus infection , hypertension, pulmonary arterial , Hypothyroidism , hypothyroidism, goitrous juvenile autoimmune , IgE response , Immunoglobulin E , infertility, tubal factor , knee osteoarthritis , latex-fruit syndrome , Leprosy , Liver Cirrhosis, Biliary , liver disease , Lupus Erythematosus, Systemic , lymphoma , Lymphoma, Follicular , multiple sclerosis , myasthenia gravis , myopia , narcolepsy , nasal polyposis , pancreatitis, autoimmune; pancreatitis, chronic calcifying , Papillomaviridae , papillomavirus infection , pemphigoid, mucous membrane , pemphigus , pemphigus vulgaris , periodontitis , pollen allergy , pollen-induced allergic rhinitis , polymyositis; dermatomyosis , pregnancy loss, recurrent , primary biliary cirrhosis , primary IgA nephropathy , psoriasis , Respiratory Function Tests , rheumatic heart disease , rheumatoid arthritis , Rhinitis, Allergic, Seasonal , sarcoidosis , schizophrenia , Scleroderma, Systemic , Sclerosis , sclerosis, systemic , sickle cell anemia , Sjogren's syndrome , sleepwalking , stomach cancer , systemic lupus erythematosus , thalassemia , thryoiditis, chronic lymphocytic , thyroid autoimmunity , thyroiditis, Hashimoto's , tuberculosis , typhoid fever , ulcerative colitis , urticaria , vitiligo , Vogt-Koyanagi-Harada syndrome , vulval lichen sclerosus , Waist Circumference , warts
Related Studies:
  1. Addison's disease
    Pani, M. A. et al. 2002, Preliminary evidence that an endogenous retroviral long-terminal repeat (LTR13) at the HLA-DQB1 gene locus confers susceptibility to Addison's disease., Clinical endocrinology. 2002 Jun;56(6):773-7. [PubMed 12072047]
    We have found preliminary evidence that the endogenous retroviral element DQ-LTR13, but not LTR3, is associated with Addison's disease. LTR13 appears to enhance HLA-DQ8 mediated disease risk. This retroviral insertion therefore might represent a novel susceptibility factor in Addison's disease, but these findings need to be confirmed in a larger data set.
  2. allergic rhinitis
    Wang, M. et al. 2004, Association between HLA class II locus and the susceptibility to Artemisia pollen-induced allergic rhinitis in Chinese population., Otolaryngology--head and neck surgery. 2004 Feb;130(2):192-6. [PubMed 14990915]
    HLA-DQA1 and -DQB1 genes may be involved in the development of Artemisia pollen-induced allergic rhinitis. HLA-DQA1*0201, DQB1*0602 alleles may be a protective factor and DQA1*0302 may be a susceptible factor for Artemisia pollen-induced allergic rhinitis.
  3. allergy
    Suzuki, K. et al. 2005, HLA class II DPB1, DQA1, DQB1, and DRB1 genotypic associations with occupational allergic cough to Bunashimeji mushroom., Tissue antigens. 2005 May;65(5):459-66. [PubMed 15853900]
    The HLA-DRB1*0803 allele alone, the DRB1*0803, DQA1*0103, DQB1*0601 haplotype, or both were negatively associated with allergy to Bunashimeji, and these alleles might be involved in the prevention of Bunashimeji mushroom-specific respiratory allergy.
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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
Expression ratio colors:

GNF Expression Atlas 1 Human Data on Affy U95 Chips


-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -3.6044-0.082 Picture PostScript Text
3' UTR -63.10192-0.329 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

+  Protein Domain and Structure Information
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+  Orthologous Genes in Other Species
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-  Descriptions from all associated GenBank mRNAs
  AF017439 - Homo sapiens MHC class II antigen (HLA-DRB1) mRNA, partial cds.
U66400 - Human MHC Class II HLA-DQB1*0301 variant (HLA-DQ) mRNA, partial cds.
M81141 - Human MHC class II HLA-DQ-beta mRNA (DR7 DQw2), complete cds.
M60028 - Human MHC class II HLA-DQ-beta (DQB1,DQw9), complete cds.
L34095 - Human (clone 3) MHC class II HLA-DQB1*0202 mRNA, 3' end.
L34097 - Human (clone 36) MHC class II HLA-DQB1*0302 mRNA, 3' end.
L34098 - Human (clones 2, 3) MHC class II HLA-DQB1*03032 mRNA, 3' end.
L40179 - Homo sapiens MHC class II HLA-DQB1*0201 mRNA, 3' end, exons 1-4 and 6.
M16996 - Human MHC class II HLA-DQ-beta (DQw3), complete cds.
AK304543 - Homo sapiens cDNA FLJ59004 complete cds, highly similar to HLA class II histocompatibility antigen, DQ(1)beta chain precursor.
AK296060 - Homo sapiens cDNA FLJ53582 complete cds, highly similar to HLA class II histocompatibility antigen, DQ(1)beta chain precursor.
AK295255 - Homo sapiens cDNA FLJ56572 complete cds, highly similar to HLA class II histocompatibility antigen, DQ(1)beta chain precursor.
M25025 - HUM MHC class II HLA-DR-beta-1 chain mRNA, partial cds downstream of segment 1.
M14189 - Human MHC class II DQ-beta chain mRNA (DR7), partial cds.
S79787 - HLA-DQB1 (DQB1*02)=human leucocyte antigen [human, cell 141, mRNA Partial, 201 nt].
M25024 - HUM MHC class II HLA-DR-beta-1 chain mRNA, partial cds.
V00529 - Human mRNA fragment coding for histocompatibility antigen HLA-DR (beta subunit).

+  Other Names for This Gene
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-  GeneReviews for This Gene
  GeneReviews article(s) related to gene HLA-DQB1:
celiac (Celiac Disease)

+  Gene Model Information
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+  Methods, Credits, and Use Restrictions
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