Addison's disease Pani, M. A. et al. 2002, Preliminary evidence that an endogenous retroviral long-terminal repeat (LTR13) at the HLA-DQB1 gene locus confers susceptibility to Addison's disease., Clinical endocrinology. 2002 Jun;56(6):773-7.
We have found preliminary evidence that the endogenous retroviral element DQ-LTR13, but not LTR3, is associated with Addison's disease. LTR13 appears to enhance HLA-DQ8 mediated disease risk. This retroviral insertion therefore might represent a novel susceptibility factor in Addison's disease, but these findings need to be confirmed in a larger data set.
allergic rhinitis Wang, M. et al. 2004, Association between HLA class II locus and the susceptibility to Artemisia pollen-induced allergic rhinitis in Chinese population., Otolaryngology--head and neck surgery. 2004 Feb;130(2):192-6.
HLA-DQA1 and -DQB1 genes may be involved in the development of Artemisia pollen-induced allergic rhinitis. HLA-DQA1*0201, DQB1*0602 alleles may be a protective factor and DQA1*0302 may be a susceptible factor for Artemisia pollen-induced allergic rhinitis.
allergy Suzuki, K. et al. 2005, HLA class II DPB1, DQA1, DQB1, and DRB1 genotypic associations with occupational allergic cough to Bunashimeji mushroom., Tissue antigens. 2005 May;65(5):459-66.
The HLA-DRB1*0803 allele alone, the DRB1*0803, DQA1*0103, DQB1*0601 haplotype, or both were negatively associated with allergy to Bunashimeji, and these alleles might be involved in the prevention of Bunashimeji mushroom-specific respiratory allergy.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on B4DHT2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF017439 - Homo sapiens MHC class II antigen (HLA-DRB1) mRNA, partial cds. U66400 - Human MHC Class II HLA-DQB1*0301 variant (HLA-DQ) mRNA, partial cds. M81141 - Human MHC class II HLA-DQ-beta mRNA (DR7 DQw2), complete cds. M60028 - Human MHC class II HLA-DQ-beta (DQB1,DQw9), complete cds. L34095 - Human (clone 3) MHC class II HLA-DQB1*0202 mRNA, 3' end. L34097 - Human (clone 36) MHC class II HLA-DQB1*0302 mRNA, 3' end. L34098 - Human (clones 2, 3) MHC class II HLA-DQB1*03032 mRNA, 3' end. L40179 - Homo sapiens MHC class II HLA-DQB1*0201 mRNA, 3' end, exons 1-4 and 6. M16996 - Human MHC class II HLA-DQ-beta (DQw3), complete cds. AK304543 - Homo sapiens cDNA FLJ59004 complete cds, highly similar to HLA class II histocompatibility antigen, DQ(1)beta chain precursor. AK296060 - Homo sapiens cDNA FLJ53582 complete cds, highly similar to HLA class II histocompatibility antigen, DQ(1)beta chain precursor. AK295255 - Homo sapiens cDNA FLJ56572 complete cds, highly similar to HLA class II histocompatibility antigen, DQ(1)beta chain precursor. M25025 - HUM MHC class II HLA-DR-beta-1 chain mRNA, partial cds downstream of segment 1. M14189 - Human MHC class II DQ-beta chain mRNA (DR7), partial cds. S79787 - HLA-DQB1 (DQB1*02)=human leucocyte antigen [human, cell 141, mRNA Partial, 201 nt]. M25024 - HUM MHC class II HLA-DR-beta-1 chain mRNA, partial cds. V00529 - Human mRNA fragment coding for histocompatibility antigen HLA-DR (beta subunit).