Human Gene HLA-DRB4 (uc011hel.2) Description and Page Index
  Description: Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), mRNA.
Transcript (Including UTRs)
   Position: chr6_mann_hap4:3,846,266-3,860,953 Size: 14,688 Total Exon Count: 6 Strand: -
Coding Region
   Position: chr6_mann_hap4:3,846,367-3,860,944 Size: 14,578 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: HLA-DRB4
CDC HuGE Published Literature: HLA-DRB4

+  Comparative Toxicogenomics Database (CTD)
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-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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+  mRNA Secondary Structure of 3' and 5' UTRs
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+  Protein Domain and Structure Information
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  M21008 - Human MHC class II HLA-DR1 beta mRNA (DR1,DQw1,Dw), 3' end.
AM056024 - Homo sapiens partial mRNA for MHC class II antigen (HLA-DRB1 gene) HLA-DRB1*15 allele, exon 2.
M16942 - Human MHC class II HLA-DRw53-associated glycoprotein beta- chain mRNA, complete cds.
M15178 - Human HLA-DR beta-chain mRNA, partial cds.
AF048707 - Homo sapiens MHC class II antigen HLA-DR mRNA (HLA-DRB4*01 variant allele), partial cds.
AF361548 - Homo sapiens MHC class II antigen (HLA-DRB4) mRNA, HLA-DRB4*0103101 allele, complete cds.
AF361549 - Homo sapiens MHC class II antigen (HLA-DRB4) mRNA, HLA-DRB4*01033 allele, complete cds.
DQ284431 - Homo sapiens clone ps1-17-T7 MHC class II antigen (HLA-DRB4) mRNA, HLA-DRB4*01030101 allele, complete cds.
M17385 - Human MHC class II HLA-DR-beta mRNA (DR7), partial cds.
GQ891550 - Homo sapiens MHC class II antigen (HLA-DRB4) mRNA, HLA-DRB4*0909 allele, complete cds.
DQ284433 - Homo sapiens clone ps1-6-T7 MHC class II antigen (HLA-DRB4) mRNA, HLA-DRB4*01030101 variant allele, complete cds.
U70544 - Homo sapiens HLA class II DRB4 null antigen (HLA-DRB4) pseudogene mRNA, null allele HLA-DRB4*0201N, partial cds.
U70543 - Homo sapiens MHC class II antigen (HLA-DRB4) pseudogene mRNA, null allele HLA-DRB4*0201N, partial cds.
M30182 - Human MHC class II HLA-DR-beta mRNA (DR2,Dw12), partial cds, clone DHO-7.
M15071 - Human MHC class II HLA-DR-beta-2 chain mRNA (DR4,Dw15), partial cds.
M14190 - Human MHC class II DR7-beta-1 chain mRNA (DR7), partial cds.
M16732 - Human MHC class II HLA-DR4/w53 first domain coding region fo DR-beta chain mRNA (Dw4).
M17388 - Human MHC class II HLA-DR-beta mRNA (DR9), partial cds.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_bbcellPathway - Bystander B Cell Activation
h_tcraPathway - Lck and Fyn tyrosine kinases in initiation of TCR Activation
h_ctla4Pathway - The Co-Stimulatory Signal During T-cell Activation
h_inflamPathway - Cytokines and Inflammatory Response
h_CSKPathway - Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor
h_il5Pathway - IL 5 Signaling Pathway
h_th1th2Pathway - Th1/Th2 Differentiation
h_asbcellPathway - Antigen Dependent B Cell Activation
h_blymphocytePathway - B Lymphocyte Cell Surface Molecules
h_eosinophilsPathway - The Role of Eosinophils in the Chemokine Network of Allergy
h_mhcPathway - Antigen Processing and Presentation

+  Other Names for This Gene
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+  Gene Model Information
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+  Methods, Credits, and Use Restrictions
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