Human Gene AGER (uc011hdj.2) Description and Page Index
  Description: Homo sapiens advanced glycosylation end product-specific receptor (AGER), transcript variant 1, mRNA.
RefSeq Summary (NM_001206954): The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:3,491,569-3,494,923 Size: 3,355 Total Exon Count: 10 Strand: -


Page IndexSequence and LinksGenetic AssociationsCTDMicroarrayOther Species
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: AGER
CDC HuGE Published Literature: AGER
Positive Disease Associations: Alzheimer's disease , antioxidant status , diabetes, type 2 , diabetic retinopathy. , myocardial infarct stroke, ischemic , nephropathy in diabetes mellitus , non-small cell lung cancer , proteinuria and cardiovascular disease , Psoriasis , pulmonary function , Respiratory Function Tests , Stroke , Type 2 Diabetes (Retinopathy)
Related Studies:
  1. Alzheimer's disease
    Daborg J et al. 2010, Association of the RAGE G82S polymorphism with Alzheimer's disease., Journal of neural transmission (Vienna, Austria : 1996) 117(7) : 861-7 2010. [PubMed 20567859]
  2. antioxidant status
    Kankova K et al. 2001, Polymorphisms 1704G/T and 2184A/G in the RAGE gene are associated with antioxidant status., Metabolism: clinical and experimental. 2001 Oct;50(10):1152-60. [PubMed 11586486]
  3. diabetes, type 2
    Kankova K et al. 1999, Association of G82S polymorphism in the RAGE gene with skin complications in type 2 diabetes., Diabetes care. 1999 Oct;22(10):1745. [PubMed 10526746]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
Ratios
      
      
      
     
    
     
Absolute
      
       
      
      
     
    
Ratios
      
       
      
      
     
    
Absolute
   
     
     
Ratios
   
     
     
Absolute

GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
Ratios
      
    
     
      
    
    
Absolute
      
      
      
Ratios
      
      
      
Absolute

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  M91211 - Human receptor for advanced glycosylation end products (RAGE) mRNA, partial cds.
AJ133822 - Homo sapiens mRNA for receptor for Advanced Glycation End Product, secreted isoform (RAGEsec gene).
AK298100 - Homo sapiens cDNA FLJ56412 complete cds, highly similar to Advanced glycosylation end product-specific receptor precursor.
BC020669 - Homo sapiens advanced glycosylation end product-specific receptor, mRNA (cDNA clone MGC:22357 IMAGE:4718076), complete cds.
HQ148134 - Homo sapiens RAGE isoform sRAGE-delta (AGER) mRNA, complete cds, alternatively spliced.
HQ148135 - Homo sapiens RAGE isoform NtRAGE-delta (AGER) mRNA, complete cds, alternatively spliced.
AB036432 - Homo sapiens RAGE mRNA for advanced glycation endproducts receptor, complete cds.
AB061668 - Homo sapiens RAGE mRNA for soluble form of receptor for advanced glycation endproducts, complete cds.
AB061669 - Homo sapiens RAGE mRNA for N-terminal truncated form of receptor for advanced glycation endproducts, complete cds.
FJ545655 - Homo sapiens advanced glycosylation end products transcript variant (AGER) mRNA, complete cds.
AY755619 - Homo sapiens receptor for advanced glycosylation end-products (AGER) mRNA, complete cds, alternatively spliced.
AY755620 - Homo sapiens receptor for advanced glycation end-products splice variant 1 (AGER) mRNA, complete cds, alternatively spliced.
AY755621 - Homo sapiens receptor for advanced glycosylation end-products intron 4 variant (AGER) mRNA, complete cds, alternatively spliced.
AY755622 - Homo sapiens receptor for advanced glycosylation end-products intron 4&9 variant (AGER) mRNA, complete cds, alternatively spliced.
AY755623 - Homo sapiens receptor for advanced glycosylation end-products deletion exon 8 and intron 9 variant (AGER) mRNA, complete cds, alternatively spliced.
AY755624 - Homo sapiens receptor for advanced glycosylation end-products deletion exon 3 variant (AGER) mRNA, complete cds, alternatively spliced.
AY755625 - Homo sapiens receptor for advanced glycosylation end-products deletion exon3-7 variant (AGER) mRNA, complete cds, alternatively spliced.
AY755626 - Homo sapiens receptor for advanced glycosylation end-products deletion exon2-6 variant (AGER) mRNA, complete cds, alternatively spliced.
AY755627 - Homo sapiens receptor for advanced glycosylation end-products deletion exon3-10 variant (AGER) mRNA, complete cds, alternatively spliced.
AY755628 - Homo sapiens receptor for advanced glycosylation end-products intron 9 and deletion exon 11 variant (AGER) mRNA, complete cds, alternatively spliced.
DQ104251 - Homo sapiens receptor for advanced glycation end-products (AGER) mRNA, complete cds, alternatively spliced.
DQ104252 - Homo sapiens receptor for advanced glycation end-products (AGER) mRNA, complete cds, alternatively spliced.
DQ104253 - Homo sapiens receptor for advanced glycation end-products (AGER) mRNA, complete cds, alternatively spliced.
DQ104254 - Homo sapiens receptor for advanced glycation end-products (AGER) mRNA, complete cds, alternatively spliced.
EU117141 - Homo sapiens receptor for advanced glycation end-products splice variant 8 (AGER) mRNA, complete cds, alternatively spliced.
HQ148133 - Homo sapiens RAGE isoform delta (AGER) mRNA, complete cds, alternatively spliced.
EU428811 - Homo sapiens advanced glycosylation end product-specific receptor variant CC (AGER) mRNA, complete cds, alternatively spliced.
EU428812 - Homo sapiens advanced glycosylation end product-specific receptor variant AA (AGER) mRNA, complete cds, alternatively spliced.
EU428813 - Homo sapiens advanced glycosylation end product-specific receptor variant BB (AGER) mRNA, complete cds, alternatively spliced.
EU428814 - Homo sapiens advanced glycosylation end product-specific receptor (AGER) mRNA, complete sequence, alternatively spliced.
EU428815 - Homo sapiens advanced glycosylation end product-specific receptor variant BB (AGER) mRNA, complete cds, alternatively spliced.
AK313178 - Homo sapiens cDNA, FLJ93677, Homo sapiens advanced glycosylation end product-specific receptor(AGER), transcript variant 1, mRNA.
EU428816 - Homo sapiens advanced glycosylation end product-specific receptor (AGER) mRNA, complete sequence, alternatively spliced.
DQ893575 - Synthetic construct clone IMAGE:100006205; FLH176388.01X; RZPDo839C09122D advanced glycosylation end product-specific receptor (AGER) gene, encodes complete protein.
DQ896821 - Synthetic construct Homo sapiens clone IMAGE:100011281; FLH176384.01L; RZPDo839C09121D advanced glycosylation end product-specific receptor (AGER) gene, encodes complete protein.
AB527569 - Synthetic construct DNA, clone: pF1KB6647, Homo sapiens AGER gene for advanced glycosylation end product-specific receptor, without stop codon, in Flexi system.
AF536236 - Homo sapiens advanced glycosylation end product-specific receptor variant sRAGE1 (AGER) mRNA, partial cds, alternatively spliced.
AF536237 - Homo sapiens advanced glycosylation end product-specific receptor variant sRAGE2 (AGER) mRNA, partial cds, alternatively spliced.
AF537303 - Homo sapiens advanced glycosylation end product-specific receptor RAGE3 (AGER) mRNA, partial cds, alternatively spliced.
AX795281 - Sequence 4 from Patent WO03051383.
AX795282 - Sequence 5 from Patent WO03051383.
AX795283 - Sequence 6 from Patent WO03051383.
EU826618 - Homo sapiens soluble RAGE variant 3 (RAGE) mRNA, complete cds, alternatively spliced.
EU826619 - Homo sapiens soluble RAGE variant 4 (RAGE) mRNA, complete cds, alternatively spliced.
EU826617 - Homo sapiens soluble RAGE variant 2 (RAGE) mRNA, complete cds, alternatively spliced.
CU676626 - Synthetic construct Homo sapiens gateway clone IMAGE:100022253 5' read AGER mRNA.
EU826620 - Homo sapiens soluble RAGE variant 5 (RAGE) mRNA, complete cds, alternatively spliced.
EU826616 - Homo sapiens soluble RAGE variant 1 (RAGE) mRNA, complete cds, alternatively spliced.
GU139370 - Homo sapiens advanced glycosylation end product-specific receptor, variant 1-like (AGER) mRNA, complete sequence, alternatively spliced.
GU139371 - Homo sapiens advanced glycosylation end product-specific receptor, splice variant 2 (AGER) mRNA, complete cds, alternatively spliced.
GU139372 - Homo sapiens advanced glycosylation end product-specific receptor, variant 3-like (AGER) mRNA, complete sequence, alternatively spliced.
GU139373 - Homo sapiens advanced glycosylation end product-specific receptor, splice variant 4 (AGER) mRNA, complete cds, alternatively spliced.
GU139374 - Homo sapiens advanced glycosylation end product-specific receptor, splice variant 5 (AGER) mRNA, complete cds, alternatively spliced.
GU139375 - Homo sapiens advanced glycosylation end product-specific receptor, splice variant 6 (AGER) mRNA, complete cds, alternatively spliced.
GU139376 - Homo sapiens advanced glycosylation end product-specific receptor, splice variant 7 (AGER) mRNA, complete cds, alternatively spliced.
GU139377 - Homo sapiens advanced glycosylation end product-specific receptor, splice variant 8 (AGER) mRNA, complete cds, alternatively spliced.
GU139378 - Homo sapiens advanced glycosylation end product-specific receptor, splice variant 9 (AGER) mRNA, complete cds, alternatively spliced.
GU139379 - Homo sapiens advanced glycosylation end product-specific receptor, variant 10-like (AGER) mRNA, complete sequence, alternatively spliced.
GU139380 - Homo sapiens advanced glycosylation end product-specific receptor, variant 11-like (AGER) mRNA, complete sequence, alternatively spliced.
GU139381 - Homo sapiens advanced glycosylation end product-specific receptor, variant 12-like (AGER) mRNA, complete sequence, alternatively spliced.
GU139382 - Homo sapiens advanced glycosylation end product-specific receptor, variant 13-like (AGER) mRNA, complete sequence, alternatively spliced.
GU139383 - Homo sapiens advanced glycosylation end product-specific receptor, variant 14-like (AGER) mRNA, complete sequence, alternatively spliced.
GU139384 - Homo sapiens advanced glycosylation end product-specific receptor, variant 15-like (AGER) mRNA, complete sequence, alternatively spliced.
KC692917 - Homo sapiens receptor for advanced glycation end-products variant 20 (AGER) mRNA, complete cds, alternatively spliced.

-  Other Names for This Gene
  Alternate Gene Symbols: DQ104253, NM_001206954
UCSC ID: uc011hdj.2
RefSeq Accession: NM_001206954

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: DQ104253.1
exon count: 10CDS single in 3' UTR: no RNA size: 1104
ORF size: 0CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1747.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 7
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.