Human Gene AGER (uc011hdb.2) Description and Page Index
  Description: Homo sapiens advanced glycosylation end product-specific receptor (AGER), transcript variant 8, mRNA.
RefSeq Summary (NM_001206954): The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:3,491,569-3,494,923 Size: 3,355 Total Exon Count: 9 Strand: -
Coding Region
   Position: chr6_mann_hap4:3,491,794-3,494,823 Size: 3,030 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Advanced glycosylation end product-specific receptor; AltName: Full=Receptor for advanced glycosylation end products; Flags: Precursor;
FUNCTION: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
SUBUNIT: Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked.
INTERACTION: Self; NbExp=2; IntAct=EBI-1646426, EBI-1646426; P62993:GRB2; NbExp=2; IntAct=EBI-1646426, EBI-401755; P16333:NCK1; NbExp=2; IntAct=EBI-1646426, EBI-389883; P61586:RHOA; NbExp=2; IntAct=EBI-1646426, EBI-446668; P04271:S100B; NbExp=5; IntAct=EBI-1646426, EBI-458391; P25815:S100P; NbExp=2; IntAct=EBI-1646426, EBI-743700; P02766:TTR; NbExp=2; IntAct=EBI-1646426, EBI-711909;
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform 2: Secreted.
TISSUE SPECIFICITY: Endothelial cells.
SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="";

+  Genetic Association Studies of Complex Diseases and Disorders
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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.20100-0.352 Picture PostScript Text
3' UTR -53.18225-0.236 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

+  Protein Domain and Structure Information
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+  Orthologous Genes in Other Species
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+  Descriptions from all associated GenBank mRNAs
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+  Other Names for This Gene
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-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001206954.1
exon count: 9CDS single in 3' UTR: no RNA size: 1321
ORF size: 978CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2339.00frame shift in genome: no % Coverage: 98.64
has start codon: yes stop codon in genome: no # of Alignments: 7
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

+  Methods, Credits, and Use Restrictions
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