Human Gene EGFL8 (uc011hcm.1) Description and Page Index
  Description: Homo sapiens EGF-like-domain, multiple 8 (EGFL8), transcript variant 2, non-coding RNA.
Transcript (Including UTRs)
   Position: chr6_mann_hap4:3,475,209-3,479,137 Size: 3,929 Total Exon Count: 9 Strand: +
Coding Region
   Position: chr6_mann_hap4:3,476,770-3,478,560 Size: 1,791 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Epidermal growth factor-like protein 8; Short=EGF-like protein 8; AltName: Full=Vascular endothelial statin-2; Short=VE-statin-2; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Potential).
SIMILARITY: Contains 2 EGF-like domains.
SIMILARITY: Contains 1 EMI domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: EGFL8
CDC HuGE Published Literature: EGFL8
Positive Disease Associations: Macular Degeneration , Phospholipids
Related Studies:
  1. Macular Degeneration
    , , . [PubMed 0]
  2. Macular Degeneration
    , , . [PubMed 0]
  3. Macular Degeneration
    , , . [PubMed 0]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips


GNF Expression Atlas 1 Human Data on Affy U95 Chips


-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.10105-0.287 Picture PostScript Text
3' UTR -201.55577-0.349 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000742 - EG-like_dom
IPR001881 - EGF-like_Ca-bd_dom
IPR013032 - EGF-like_CS
IPR000152 - EGF-type_Asp/Asn_hydroxyl_site
IPR018097 - EGF_Ca-bd_CS
IPR011489 - EMI_domain

Pfam Domains:
PF00008 - EGF-like domain
PF07546 - EMI domain
PF07645 - Calcium binding EGF domain
PF07974 - EGF-like domain

SCOP Domains:
57196 - EGF/Laminin

ModBase Predicted Comparative 3D Structure on Q99944
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     

-  Descriptions from all associated GenBank mRNAs
  AK307427 - Homo sapiens cDNA, FLJ97375.
AF020544 - Homo sapiens inactive palmitoyl-protein thioesterase-2i (PPT2) mRNA, complete cds.
AK296648 - Homo sapiens cDNA FLJ52513 complete cds, highly similar to Lysosomal thioesterase PPT2 precursor (EC 3.1.2.-).
AK290473 - Homo sapiens cDNA FLJ78536 complete cds, highly similar to Homo sapiens inactive palmitoyl-protein thioesterase-2i (PPT2) mRNA.
AK292729 - Homo sapiens cDNA FLJ75166 complete cds, highly similar to Homo sapiens palmitoyl-protein thioesterase 2 (PPT2), transcriptvariant 3, mRNA.
BC052591 - Homo sapiens EGF-like-domain, multiple 8, mRNA (cDNA clone MGC:59719 IMAGE:6295477), complete cds.
BC035574 - Homo sapiens EGF-like-domain, multiple 8, mRNA (cDNA clone MGC:44938 IMAGE:5247785), complete cds.
AY358139 - Homo sapiens clone DNA178658 NG3 (UNQ8752) mRNA, complete cds.
AK126457 - Homo sapiens cDNA FLJ44493 fis, clone UTERU2035452, highly similar to Homo sapiens NG3.
AK309657 - Homo sapiens cDNA, FLJ99698.
AB190520 - Homo sapiens mRNA for VE-statin2, complete cds.
CU690110 - Synthetic construct Homo sapiens gateway clone IMAGE:100016679 5' read EGFL8 mRNA.
CU690920 - Synthetic construct Homo sapiens gateway clone IMAGE:100022393 5' read EGFL8 mRNA.
HQ448382 - Synthetic construct Homo sapiens clone IMAGE:100071809; CCSB013658_04 palmitoyl-protein thioesterase 2 (PPT2) gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: B0S884, C6orf8, EGFL8_HUMAN, G5E9Q0, NG3, NM_030652, NP_085155, NR_037860, Q5JP23, Q5SSX3, Q8IV30, Q99944, UNQ8752/PRO29920
UCSC ID: uc011hcm.1
RefSeq Accession: NM_030652
Protein: Q99944 (aka EGFL8_HUMAN