Human Gene PRRT1 (uc011hcb.1) Description and Page Index
  Description: Homo sapiens proline-rich transmembrane protein 1 (PRRT1), mRNA.
Transcript (Including UTRs)
   Position: chr6_mann_hap4:3,458,984-3,462,564 Size: 3,581 Total Exon Count: 4 Strand: -
Coding Region
   Position: chr6_mann_hap4:3,459,843-3,462,448 Size: 2,606 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
  ID: PRRT1_HUMAN
DESCRIPTION: RecName: Full=Proline-rich transmembrane protein 1; AltName: Full=Dispanin subfamily D member 1; Short=DSPD1;
SUBUNIT: Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse (By similarity).
SIMILARITY: Belongs to the CD225/Dispanin family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: PRRT1
CDC HuGE Published Literature: PRRT1

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -38.10116-0.328 Picture PostScript Text
3' UTR -274.75859-0.320 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007593 - CD225/Dispanin_fam

ModBase Predicted Comparative 3D Structure on Q99946
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  AF085841 - Homo sapiens full length insert cDNA clone YI44H12.
AK123424 - Homo sapiens cDNA FLJ41430 fis, clone BRHIP2005752, highly similar to Homo sapiens NG5.
BC013201 - Homo sapiens proline-rich transmembrane protein 1, mRNA (cDNA clone MGC:18030 IMAGE:3924575), complete cds.
BC063046 - Homo sapiens proline-rich transmembrane protein 1, mRNA (cDNA clone MGC:65172 IMAGE:5197474), complete cds.
AK054885 - Homo sapiens cDNA FLJ30323 fis, clone BRACE2007109, highly similar to Extensin-like protein NG5.

-  Other Names for This Gene
  Alternate Gene Symbols: A6ND08, A6ND40, B0S869, C6orf31, NG5, NM_030651, NP_085154, PRRT1_HUMAN, Q5SSW4, Q5SSX7, Q5STI1, Q96DW3, Q96NQ8, Q99946
UCSC ID: uc011hcb.1
RefSeq Accession: NM_030651
Protein: Q99946 (aka PRRT1_HUMAN