Human Gene C2 (uc011hbu.2) Description and Page Index
  Description: Homo sapiens complement component 2 (C2), transcript variant 4, non-coding RNA.
Transcript (Including UTRs)
   Position: chr6_mann_hap4:3,244,196-3,256,269 Size: 12,074 Total Exon Count: 13 Strand: +
Coding Region
   Position: chr6_mann_hap4:3,244,259-3,255,954 Size: 11,696 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: C2
CDC HuGE Published Literature: C2
Positive Disease Associations: C2-deficiency gene , Carcinoma, Hepatocellular , Cross Infection|Pneumonia, Ventilator-Associated|Wounds and Injuries , Diabetes Mellitus, Type 1 , Hepatitis B Vaccines , Lupus Erythematosus, Systemic , macular degeneration , Multiple Sclerosis , Psoriasis
Related Studies:
  1. C2-deficiency gene
    Poncet D et al. 1982, Association of the C2-deficiency gene (C2*QO) with the C4A*4 C4B*2 genes., Journal of immunogenetics. 1982 Apr;9(2):127-32. [PubMed 7086154]
  2. Carcinoma, Hepatocellular
    Robert J Clifford et al. Hepatology (Baltimore, Md.) 2010, Genetic variations at loci involved in the immune response are risk factors for hepatocellular carcinoma., Hepatology (Baltimore, Md.). [PubMed 21105107]
  3. Cross Infection|Pneumonia, Ventilator-Associated|Wounds and Injuries
    John A Morris , et al. The Journal of trauma 2009 66(5):1265-70; discussion 1270-2, Genetic variation in complement component 2 of the classical complement pathway is associated with increased mortality and infection: a study of 627 patients with trauma., The Journal of trauma 2009 66(5):1265-70; discussion 1270-2. [PubMed 19430225]
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+  Comparative Toxicogenomics Database (CTD)
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-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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+  mRNA Secondary Structure of 3' and 5' UTRs
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+  Protein Domain and Structure Information
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  AK312581 - Homo sapiens cDNA, FLJ92956, Homo sapiens complement component 2 (C2), mRNA.
AK304045 - Homo sapiens cDNA FLJ55673 complete cds, highly similar to Complement factor B precursor (EC 3.4.21.47).
BC029781 - Homo sapiens complement component 2, mRNA (cDNA clone IMAGE:5183067), complete cds.
AK300892 - Homo sapiens cDNA FLJ54076 complete cds, highly similar to Complement C2 precursor (EC 3.4.21.43).
X04481 - Human mRNA for complement component C2.
AK307930 - Homo sapiens cDNA, FLJ97878.
AK222537 - Homo sapiens mRNA for complement component 2 precursor variant, clone: adSE01995.
AK300930 - Homo sapiens cDNA FLJ55526 complete cds, highly similar to Complement C2 precursor (EC 3.4.21.43).
BC043484 - Homo sapiens complement component 2, mRNA (cDNA clone MGC:49826 IMAGE:5763774), complete cds.
AK222783 - Homo sapiens mRNA for complement component 2 precursor variant, clone: HEP01788.
AK298808 - Homo sapiens cDNA FLJ54376 complete cds, highly similar to Complement C2 precursor (EC 3.4.21.43).
AK096258 - Homo sapiens cDNA FLJ38939 fis, clone NT2NE2015747, highly similar to COMPLEMENT C2 PRECURSOR (EC 3.4.21.43).
AK298311 - Homo sapiens cDNA FLJ59728 complete cds, highly similar to Complement C2 precursor (EC 3.4.21.43).
BX537504 - Homo sapiens mRNA; cDNA DKFZp779M0311 (from clone DKFZp779M0311).

+  Biochemical and Signaling Pathways
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+  Other Names for This Gene
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-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NR_073063.1
exon count: 13CDS single in 3' UTR: no RNA size: 2086
ORF size: 1521CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 3242.00frame shift in genome: no % Coverage: 91.04
has start codon: yes stop codon in genome: no # of Alignments: 7
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.