Human Gene MSH5 (uc011hbh.2) Description and Page Index
  Description: Homo sapiens mutS homolog 5 (E. coli) (MSH5), transcript variant 3, mRNA.
RefSeq Summary (NM_172166): This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:3,050,615-3,058,094 Size: 7,480 Total Exon Count: 10 Strand: +
Coding Region
   Position: chr6_mann_hap4:3,051,134-3,058,094 Size: 6,961 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=MutS protein homolog 5; Short=hMSH5;
FUNCTION: Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis (By similarity).
SUBUNIT: Heterooligomer of MSH4 and MSH5. Interacts with HJURP.
INTERACTION: P00519:ABL1; NbExp=10; IntAct=EBI-6092730, EBI-375543; O15457:MSH4; NbExp=5; IntAct=EBI-6092730, EBI-6092777;
TISSUE SPECIFICITY: Ubiquitous, but highly expressed in testis, and thymus.
SIMILARITY: Belongs to the DNA mismatch repair MutS family.

+  Genetic Association Studies of Complex Diseases and Disorders
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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -138.20286-0.483 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

+  Protein Domain and Structure Information
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+  Orthologous Genes in Other Species
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+  Descriptions from all associated GenBank mRNAs
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+  Other Names for This Gene
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-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_002441.4
exon count: 10CDS single in 3' UTR: no RNA size: 2945
ORF size: 813CDS single in intron: no Alignment % ID: 99.91
txCdsPredict score: 1743.00frame shift in genome: no % Coverage: 37.32
has start codon: yes stop codon in genome: no # of Alignments: 8
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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+  Methods, Credits, and Use Restrictions
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