Human Gene CLIC1 (uc011hbd.1) Description and Page Index
  Description: Homo sapiens chloride intracellular channel 1 (CLIC1), mRNA.
RefSeq Summary (NM_001288): Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:3,041,248-3,047,235 Size: 5,988 Total Exon Count: 6 Strand: -
Coding Region
   Position: chr6_mann_hap4:3,041,509-3,046,971 Size: 5,463 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: CLIC1
CDC HuGE Published Literature: CLIC1

+  Comparative Toxicogenomics Database (CTD)
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+  Microarray Expression Data
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+  mRNA Secondary Structure of 3' and 5' UTRs
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010987 - Glutathione-S-Trfase_C-like
IPR004045 - Glutathione_S-Trfase_N
IPR002946 - Int_Cl_channel
IPR012336 - Thioredoxin-like_fold

SCOP Domains:
47616 - Glutathione S-transferase (GST), C-terminal domain
52833 - Thioredoxin-like

Protein Data Bank (PDB) 3-D Structure

1K0M
- X-ray Chimera LS-SNP

1K0N
- X-ray Chimera LS-SNP

1K0O
- X-ray Chimera LS-SNP
To conserve bandwidth, only the images from the first 3 structures are shown.
1RK4 - X-ray Chimera LS-SNP 3O3T - X-ray Chimera LS-SNP 3P8W - X-ray Chimera LS-SNP
3P90 - X-ray Chimera LS-SNP 3QR6 - X-ray Chimera 3SWL - X-ray Chimera
3TGZ - X-ray Chimera 3UVH - X-ray Chimera 4IQA - X-ray Chimera
Chimera help

ModBase Predicted Comparative 3D Structure on O00299
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

+  Orthologous Genes in Other Species
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+  Descriptions from all associated GenBank mRNAs
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-  Other Names for This Gene
  Alternate Gene Symbols: CLIC1_HUMAN, G6, NCC27, NM_001288, NP_001279, O00299, Q15089, Q502X1
UCSC ID: uc011hbd.1
RefSeq Accession: NM_001288
Protein: O00299 (aka CLIC1_HUMAN