Human Gene DDAH2 (uc011hbc.2) Description and Page Index
Description: Homo sapiens dimethylarginine dimethylaminohydrolase 2 (DDAH2), mRNA. RefSeq Summary (NM_013974): This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF070667.1, AF087894.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025083 [ECO:0000348] ##Evidence-Data-END## Transcript (Including UTRs) Position: chr6_mann_hap4:3,037,707-3,040,929 Size: 3,223 Total Exon Count: 7 Strand: - Coding Region Position: chr6_mann_hap4:3,037,904-3,039,828 Size: 1,925 Coding Exon Count: 6
Cerebral Hemorrhage|Stroke Yongyi Bai , et al. Clinical science 2009 117(7):273-9, Common genetic variation in DDAH2 is associated with intracerebral haemorrhage in a Chinese population: a multi-centre case-control study in China., Clinical science 2009 117(7):273-9.
hypertension Renke Maas , et al. Pharmacological research 2009 60(6):488-93, Polymorphisms in the promoter region of the dimethylarginine dimethylaminohydrolase 2 gene are associated with prevalence of hypertension., Pharmacological research 2009 60(6):488-93.
vasopressor infusion requirement Ryan, R. et al. 2006, Gene polymorphism and requirement for vasopressor infusion after cardiac surgery, Ann Thorac Surg 2006 82(3) 895-901.
Vasopressor requirement after surgery may be related to an interaction of genotype, preoperative morbidity, and prolonged surgery.