Human Gene DDAH2 (uc011hbc.2) Description and Page Index
  Description: Homo sapiens dimethylarginine dimethylaminohydrolase 2 (DDAH2), mRNA.
RefSeq Summary (NM_013974): This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF070667.1, AF087894.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025083 [ECO:0000348] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: chr6_mann_hap4:3,037,707-3,040,929 Size: 3,223 Total Exon Count: 7 Strand: -
Coding Region
   Position: chr6_mann_hap4:3,037,904-3,039,828 Size: 1,925 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=N(G),N(G)-dimethylarginine dimethylaminohydrolase 2; Short=DDAH-2; Short=Dimethylarginine dimethylaminohydrolase 2; EC=; AltName: Full=DDAHII; AltName: Full=Dimethylargininase-2; AltName: Full=Protein G6a; AltName: Full=S-phase protein;
FUNCTION: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
CATALYTIC ACTIVITY: N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrulline.
INTERACTION: Q15645:TRIP13; NbExp=3; IntAct=EBI-749139, EBI-358993;
SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion. Note=Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes.
TISSUE SPECIFICITY: Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very low levels in brain.
SIMILARITY: Belongs to the DDAH family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: DDAH2
CDC HuGE Published Literature: DDAH2
Positive Disease Associations: Cerebral Hemorrhage|Stroke , hypertension , vasopressor infusion requirement
Related Studies:
  1. Cerebral Hemorrhage|Stroke
    Yongyi Bai , et al. Clinical science 2009 117(7):273-9, Common genetic variation in DDAH2 is associated with intracerebral haemorrhage in a Chinese population: a multi-centre case-control study in China., Clinical science 2009 117(7):273-9. [PubMed 19250061]
  2. hypertension
    Renke Maas , et al. Pharmacological research 2009 60(6):488-93, Polymorphisms in the promoter region of the dimethylarginine dimethylaminohydrolase 2 gene are associated with prevalence of hypertension., Pharmacological research 2009 60(6):488-93. [PubMed 19666123]
  3. vasopressor infusion requirement
    Ryan, R. et al. 2006, Gene polymorphism and requirement for vasopressor infusion after cardiac surgery, Ann Thorac Surg 2006 82(3) 895-901. [PubMed 16928504]
    Vasopressor requirement after surgery may be related to an interaction of genotype, preoperative morbidity, and prolonged surgery.
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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips


GNF Expression Atlas 1 Human Data on Affy U95 Chips


-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -108.34276-0.393 Picture PostScript Text
3' UTR -57.92197-0.294 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003198 - Amidino_trans

Pfam Domains:
PF02274 - Amidinotransferase

SCOP Domains:
55909 - Pentein

ModBase Predicted Comparative 3D Structure on O95865
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     

-  Descriptions from all associated GenBank mRNAs
  AK026191 - Homo sapiens cDNA: FLJ22538 fis, clone HRC13212, highly similar to AF070667 Homo sapiens NG,NG-dimethylarginine dimethylaminohydrolase homolog mRNA.
BC001435 - Homo sapiens dimethylarginine dimethylaminohydrolase 2, mRNA (cDNA clone MGC:1351 IMAGE:3138832), complete cds.
AK098671 - Homo sapiens cDNA FLJ25805 fis, clone TST07191, highly similar to NG,NG-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 2 (EC
AF070667 - Homo sapiens NG,NG-dimethylarginine dimethylaminohydrolase homolog mRNA, complete cds.
AF087894 - Homo sapiens S-phase protein mRNA, complete cds.
AK310024 - Homo sapiens cDNA, FLJ17066.
FJ224290 - Homo sapiens epididymis secretory protein Li 277 (HEL-S-277) mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: A2BEZ7, DDAH, DDAH2_HUMAN, G6A, NG30, NM_013974, NP_039268, O95865
UCSC ID: uc011hbc.2
RefSeq Accession: NM_013974
Protein: O95865 (aka DDAH2_HUMAN