Human Gene LY6G6C (uc011hat.2) Description and Page Index
  Description: Homo sapiens lymphocyte antigen 6 complex, locus G6C (LY6G6C), mRNA.
RefSeq Summary (NM_025261): LY6G6C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008]. ##Evidence-Data-START## Transcript exon combination :: BC036302.1, BM716645.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025083, ERS025089 [ECO:0000350] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: chr6_mann_hap4:3,029,314-3,032,400 Size: 3,087 Total Exon Count: 3 Strand: -
Coding Region
   Position: chr6_mann_hap4:3,029,762-3,032,345 Size: 2,584 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Comments and Description Text from UniProtKB
  ID: LY66C_HUMAN
DESCRIPTION: RecName: Full=Lymphocyte antigen 6 complex locus protein G6c; Flags: Precursor;
SUBUNIT: Monomer.
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
TISSUE SPECIFICITY: Highly expressed at the leading edges of cells, on filopodia.
PTM: N-glycosylated.
SIMILARITY: Contains 1 UPAR/Ly6 domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: LY6G6C
CDC HuGE Published Literature: LY6G6C
Positive Disease Associations: Lupus Erythematosus, Systemic
Related Studies:
  1. Lupus Erythematosus, Systemic
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
Ratios
      
      
      
     
    
     
Absolute
      
       
      
      
     
    
Ratios
      
       
      
      
     
    
Absolute
   
     
     
Ratios
   
     
     
Absolute

GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
Ratios
      
    
     
      
    
    
Absolute
      
      
      
Ratios
      
      
      
Absolute

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -6.9055-0.125 Picture PostScript Text
3' UTR -115.77448-0.258 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  SCOP Domains:
57302 - Snake toxin-like

ModBase Predicted Comparative 3D Structure on O95867
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Jackson Lab     
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  BC036302 - Homo sapiens lymphocyte antigen 6 complex, locus G6C, mRNA (cDNA clone MGC:24882 IMAGE:4776231), complete cds.
AY359119 - Homo sapiens clone DNA96878 G6C (UNQ1947) mRNA, complete cds.
AJ315533 - Homo sapiens mRNA for LY6G6C protein, splice variant 1.
AJ315534 - Homo sapiens mRNA for truncated LY6G6C protein, splice variant 2.

-  Other Names for This Gene
  Alternate Gene Symbols: C6orf24, G6C, LY66C_HUMAN, NG24, NM_025261, NP_079537, O95867, Q5SRS8, Q8IY94, UNQ1947/PRO4430
UCSC ID: uc011hat.2
RefSeq Accession: NM_025261
Protein: O95867 (aka LY66C_HUMAN