Human Gene LY6G6F (uc011hal.1) Description and Page Index
  Description: Homo sapiens lymphocyte antigen 6 complex, locus G6F (LY6G6F), mRNA.
RefSeq Summary (NM_001003693): The human G6f protein is a type I transmembrane protein belonging to the immunoglobin (Ig) superfamily, which is comprised of cell-surface proteins involved in the immune system and cellular recognition (de Vet et al., 2003 [PubMed 12852788]).[supplied by OMIM, Mar 2008]. ##Evidence-Data-START## Transcript exon combination :: AJ496460.1, BC137212.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025087, ERS025091 [ECO:0000348] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: chr6_mann_hap4:3,017,576-3,021,267 Size: 3,692 Total Exon Count: 6 Strand: +
Coding Region
   Position: chr6_mann_hap4:3,017,576-3,021,263 Size: 3,688 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
Protein StructureOther SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
  ID: LY66F_HUMAN
DESCRIPTION: RecName: Full=Lymphocyte antigen 6 complex locus protein G6f; Flags: Precursor;
FUNCTION: May play a role in the downstream signal transduction pathways involving GRB2 and GRB7.
SUBUNIT: Homodimer; disulfide-linked. Interacts with GRB2 and GRB7 in a phosphorylation-dependent manner.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
PTM: N-glycosylated.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SEQUENCE CAUTION: Sequence=AAD18078.1; Type=Erroneous gene model prediction; Sequence=BAB63382.1; Type=Erroneous gene model prediction;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: LY6G6F
CDC HuGE Published Literature: LY6G6F
Positive Disease Associations: Macular Degeneration
Related Studies:
  1. Macular Degeneration
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like_dom
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013106 - Ig_V-set
IPR026524 - LY6G6d/LY6G6f

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on Q5SQ64
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  BC137213 - Homo sapiens lymphocyte antigen 6 complex, locus G6F, mRNA (cDNA clone MGC:168833 IMAGE:9021210), complete cds.
BC137212 - Homo sapiens lymphocyte antigen 6 complex, locus G6F, mRNA (cDNA clone MGC:168832 IMAGE:9021209), complete cds.
AF195764 - Homo sapiens megakaryocyte-enhanced gene transcript 1 protein (MEGT1) mRNA, complete cds.
AJ496460 - Homo sapiens mRNA for G6f protein.

-  Other Names for This Gene
  Alternate Gene Symbols: B0UXB7, C6orf21, G6F, LY66F_HUMAN, LY6G6D, NG32, NM_001003693, NP_001003693, O95869, Q5SQ64, Q7Z5H2, Q96QC7
UCSC ID: uc011hal.1
RefSeq Accession: NM_001003693
Protein: Q5SQ64 (aka LY66F_HUMAN