Human Gene LY6G6F (uc011hal.1) Description and Page Index
Description: Homo sapiens lymphocyte antigen 6 complex, locus G6F (LY6G6F), mRNA. RefSeq Summary (NM_001003693): The human G6f protein is a type I transmembrane protein belonging to the immunoglobin (Ig) superfamily, which is comprised of cell-surface proteins involved in the immune system and cellular recognition (de Vet et al., 2003 [PubMed 12852788]).[supplied by OMIM, Mar 2008]. ##Evidence-Data-START## Transcript exon combination :: AJ496460.1, BC137212.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025087, ERS025091 [ECO:0000348] ##Evidence-Data-END## Transcript (Including UTRs) Position: chr6_mann_hap4:3,017,576-3,021,267 Size: 3,692 Total Exon Count: 6 Strand: + Coding Region Position: chr6_mann_hap4:3,017,576-3,021,263 Size: 3,688 Coding Exon Count: 6
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Comments and Description Text from UniProtKB
ID:LY66F_HUMAN DESCRIPTION: RecName: Full=Lymphocyte antigen 6 complex locus protein G6f; Flags: Precursor; FUNCTION: May play a role in the downstream signal transduction pathways involving GRB2 and GRB7. SUBUNIT: Homodimer; disulfide-linked. Interacts with GRB2 and GRB7 in a phosphorylation-dependent manner. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. PTM: N-glycosylated. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. SEQUENCE CAUTION: Sequence=AAD18078.1; Type=Erroneous gene model prediction; Sequence=BAB63382.1; Type=Erroneous gene model prediction;
Genetic Association Studies of Complex Diseases and Disorders
ModBase Predicted Comparative 3D Structure on Q5SQ64
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.