Human Gene LY6G6F (uc011hal.1) Description and Page Index
  Description: Homo sapiens lymphocyte antigen 6 complex, locus G6F (LY6G6F), mRNA.
RefSeq Summary (NM_001003693): The human G6f protein is a type I transmembrane protein belonging to the immunoglobin (Ig) superfamily, which is comprised of cell-surface proteins involved in the immune system and cellular recognition (de Vet et al., 2003 [PubMed 12852788]).[supplied by OMIM, Mar 2008]. ##Evidence-Data-START## Transcript exon combination :: AJ496460.1, BC137212.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025087, ERS025091 [ECO:0000348] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: chr6_mann_hap4:3,017,576-3,021,267 Size: 3,692 Total Exon Count: 6 Strand: +
Coding Region
   Position: chr6_mann_hap4:3,017,576-3,021,263 Size: 3,688 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
Protein StructureOther SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Lymphocyte antigen 6 complex locus protein G6f; Flags: Precursor;
FUNCTION: May play a role in the downstream signal transduction pathways involving GRB2 and GRB7.
SUBUNIT: Homodimer; disulfide-linked. Interacts with GRB2 and GRB7 in a phosphorylation-dependent manner.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
PTM: N-glycosylated.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SEQUENCE CAUTION: Sequence=AAD18078.1; Type=Erroneous gene model prediction; Sequence=BAB63382.1; Type=Erroneous gene model prediction;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: LY6G6F
CDC HuGE Published Literature: LY6G6F
Positive Disease Associations: Macular Degeneration
Related Studies:
  1. Macular Degeneration
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips


-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like_dom
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013106 - Ig_V-set
IPR026524 - LY6G6d/LY6G6f

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on Q5SQ64
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     

-  Descriptions from all associated GenBank mRNAs
  BC137213 - Homo sapiens lymphocyte antigen 6 complex, locus G6F, mRNA (cDNA clone MGC:168833 IMAGE:9021210), complete cds.
BC137212 - Homo sapiens lymphocyte antigen 6 complex, locus G6F, mRNA (cDNA clone MGC:168832 IMAGE:9021209), complete cds.
AF195764 - Homo sapiens megakaryocyte-enhanced gene transcript 1 protein (MEGT1) mRNA, complete cds.
AJ496460 - Homo sapiens mRNA for G6f protein.

-  Other Names for This Gene
  Alternate Gene Symbols: B0UXB7, C6orf21, G6F, LY66F_HUMAN, LY6G6D, NG32, NM_001003693, NP_001003693, O95869, Q5SQ64, Q7Z5H2, Q96QC7
UCSC ID: uc011hal.1
RefSeq Accession: NM_001003693
Protein: Q5SQ64 (aka LY66F_HUMAN