Human Gene LY6G5B (uc011haa.1) Description and Page Index
  Description: Homo sapiens lymphocyte antigen 6 complex, locus G5B (LY6G5B), mRNA.
RefSeq Summary (NM_021221): LY6G5B belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008]. ##Evidence-Data-START## Transcript exon combination :: AJ315545.1, AK289364.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025093 [ECO:0000348] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,981,618-2,983,117 Size: 1,500 Total Exon Count: 3 Strand: +
Coding Region
   Position: chr6_mann_hap4:2,981,618-2,982,949 Size: 1,332 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Comments and Description Text from UniProtKB
  ID: LY65B_HUMAN
DESCRIPTION: RecName: Full=Lymphocyte antigen 6 complex locus protein G5b; Flags: Precursor;
SUBUNIT: Forms oligomer.
SUBCELLULAR LOCATION: Secreted (Potential).
PTM: N-glycosylated.
SIMILARITY: Contains 1 UPAR/Ly6 domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: LY6G5B
CDC HuGE Published Literature: LY6G5B

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -25.43168-0.151 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q8NDX9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  AK289364 - Homo sapiens cDNA FLJ76984 complete cds, highly similar to Homo sapiens lymphocyte antigen 6 complex, locus G5B (LY6G5B), mRNA.
AJ245417 - Homo sapiens partial mRNA for LY6G5b protein.
AB463846 - Synthetic construct DNA, clone: pF1KB7209, Homo sapiens LY6G5B gene for lymphocyte antigen 6 complex, locus G5B, without stop codon, in Flexi system.
BC140260 - Synthetic construct Homo sapiens clone IMAGE:100014274, MGC:173227 lymphocyte antigen 6 complex, locus G5B (LY6G5B) mRNA, encodes complete protein.
BC146529 - Synthetic construct Homo sapiens clone IMAGE:100014883, MGC:180152 lymphocyte antigen 6 complex, locus G5B (LY6G5B) mRNA, encodes complete protein.
AJ315545 - Homo sapiens mRNA for LY6G5B protein (LY6G5B gene).
HE864452 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 182 (CSNK2B-LY6G5B-182 gene).
HE864453 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 532 (CSNK2B-LY6G5B-532 gene).
HE864454 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 560 (CSNK2B-LY6G5B-560 gene).
HE864455 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 562 (CSNK2B-LY6G5B-562 gene).
HE864456 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 696 (CSNK2B-LY6G5B-696 gene).
HE864457 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 991 (CSNK2B-LY6G5B--991 gene).
HE864459 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 1103 (CSNK2B-LY6G5B-1103 gene).
HE864460 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 1181 (CSNK2B-LY6G5B-1181 gene).
HE864461 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 1327 (CSNK2B-LY6G5B-1327 gene).
HE864458 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 1072 (CSNK2B-LY6G5B-1072 gene).
HE864448 - Homo sapiens partial mRNA for lymphocyte antigen-6 G5B splicing isoform 288 (LY6G5B gene).
HE864449 - Homo sapiens partial mRNA for lymphocyte antigen-6 G5B splicing isoform 452 (LY6G5B gene).
HE864450 - Homo sapiens partial mRNA for lymphocyte antigen-6 G5B splicing isoform 690 (LY6G5B gene).
HE864451 - Homo sapiens partial mRNA for lymphocyte antigen-6 G5B splicing isoform 837 (LY6G5B gene).

-  Other Names for This Gene
  Alternate Gene Symbols: B0UXB2, B0UZ65, B0UZP8, B7ZCA3, C6orf19, G5B, LY65B_HUMAN, NM_021221, NP_067044, Q5SQ62, Q5SST3, Q8NDX9, Q9UKT0, Q9UMQ0
UCSC ID: uc011haa.1
RefSeq Accession: NM_021221
Protein: Q8NDX9 (aka LY65B_HUMAN