Human Gene CSNK2B (uc011gzy.1) Description and Page Index
  Description: Homo sapiens casein kinase 2, beta polypeptide (CSNK2B), mRNA.
RefSeq Summary (NM_001320): This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,976,547-2,980,733 Size: 4,187 Total Exon Count: 7 Strand: +
Coding Region
   Position: chr6_mann_hap4:2,977,499-2,980,593 Size: 3,095 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Casein kinase II subunit beta; Short=CK II beta; AltName: Full=Phosvitin; AltName: Full=Protein G5a;
FUNCTION: Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.
SUBUNIT: Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.
INTERACTION: Self; NbExp=7; IntAct=EBI-348169, EBI-348169; O00555:CACNA1A; NbExp=2; IntAct=EBI-348169, EBI-766279; O00257-3:CBX4; NbExp=2; IntAct=EBI-348169, EBI-4392727; Q9JK25:Clip1 (xeno); NbExp=2; IntAct=EBI-348169, EBI-908338; O08785:Clock (xeno); NbExp=2; IntAct=EBI-348169, EBI-79859; P68400:CSNK2A1; NbExp=13; IntAct=EBI-348169, EBI-347804; P19784:CSNK2A2; NbExp=6; IntAct=EBI-348169, EBI-347451; Q6VY07:PACS1; NbExp=3; IntAct=EBI-348169, EBI-2555014; Q96EB6:SIRT1; NbExp=5; IntAct=EBI-348169, EBI-1802965;
PTM: Phosphorylated by alpha subunit.
SIMILARITY: Belongs to the casein kinase 2 subunit beta family.
SEQUENCE CAUTION: Sequence=CAI18393.2; Type=Erroneous initiation;

+  Genetic Association Studies of Complex Diseases and Disorders
  Press "+" in the title bar above to open this section.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -113.05340-0.333 Picture PostScript Text
3' UTR -30.00140-0.214 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

+  Protein Domain and Structure Information
  Press "+" in the title bar above to open this section.

+  Orthologous Genes in Other Species
  Press "+" in the title bar above to open this section.

+  Descriptions from all associated GenBank mRNAs
  Press "+" in the title bar above to open this section.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04310 - Wnt signaling pathway
hsa04520 - Adherens junction
hsa04530 - Tight junction

+  Other Names for This Gene
  Press "+" in the title bar above to open this section.

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001320.5
exon count: 7CDS single in 3' UTR: no RNA size: 1128
ORF size: 648CDS single in intron: no Alignment % ID: 99.82
txCdsPredict score: 1496.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 7
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

+  Methods, Credits, and Use Restrictions
  Press "+" in the title bar above to open this section.