Human Gene CSNK2B (uc011gzy.1) Description and Page Index
  Description: Homo sapiens casein kinase 2, beta polypeptide (CSNK2B), mRNA.
RefSeq Summary (NM_001320): This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,976,547-2,980,733 Size: 4,187 Total Exon Count: 7 Strand: +
Coding Region
   Position: chr6_mann_hap4:2,977,499-2,980,593 Size: 3,095 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: CSNK2B
CDC HuGE Published Literature: CSNK2B
Positive Disease Associations: Lupus Erythematosus, Systemic
Related Studies:
  1. Lupus Erythematosus, Systemic
    Geoffrey Hom et al. The New England journal of medicine 2008, Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX., The New England journal of medicine. [PubMed 18204098]
    We identified and then confirmed through replication two new genetic loci for SLE: a promoter-region allele associated with reduced expression of BLK and increased expression of C8orf13 and variants in the ITGAM-ITGAX region.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -113.05340-0.333 Picture PostScript Text
3' UTR -30.00140-0.214 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

+  Protein Domain and Structure Information
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+  Orthologous Genes in Other Species
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-  Descriptions from all associated GenBank mRNAs
  BC112019 - Homo sapiens casein kinase 2, beta polypeptide, mRNA (cDNA clone MGC:138224 IMAGE:8327487), complete cds.
BC112017 - Homo sapiens casein kinase 2, beta polypeptide, mRNA (cDNA clone MGC:138222 IMAGE:8327485), complete cds.
AK310551 - Homo sapiens cDNA, FLJ17593.
AK308742 - Homo sapiens cDNA, FLJ98783.
AK300671 - Homo sapiens cDNA FLJ50688 complete cds, highly similar to Casein kinase II subunit beta.
X16312 - Human mRNA for phosvitin/casein kinase II beta subunit.
X16937 - Human mRNA for phosvitin/casein kinase type II beta subunit (EC 2.7.1.37).
AK310954 - Homo sapiens cDNA, FLJ17996.
AK311860 - Homo sapiens cDNA, FLJ92126, Homo sapiens casein kinase 2, beta polypeptide (CSNK2B), mRNA.
M30448 - Human casein kinase II beta subunit mRNA, complete cds.
AB590710 - Synthetic construct DNA, clone: pFN21AE1709, Homo sapiens CSNK2B gene for casein kinase 2, beta polypeptide, without stop codon, in Flexi system.
CR541699 - Homo sapiens full open reading frame cDNA clone RZPDo834F0628D for gene CSNK2B, casein kinase 2, beta polypeptide; complete cds, without stopcodon.
AY113186 - Homo sapiens casein kinase II beta subunit mRNA, complete cds.
HE864443 - Homo sapiens mRNA for casein kinase II b subunit splicing isoform 132 (CSNK2B gene).
HE864444 - Homo sapiens mRNA for casein kinase II b subunit splicing isoform 247 (CSNK2B gene).
HE864445 - Homo sapiens mRNA for casein kinase II b subunit splicing isoform 318 (CSNK2B gene).
HE864446 - Homo sapiens mRNA for casein kinase II b subunit splicing isoform 660 (CSNK2B gene).
HE864447 - Homo sapiens mRNA for casein kinase II b subunit splicing isoform 806 (CSNK2B gene).
HE864452 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 182 (CSNK2B-LY6G5B-182 gene).
HE864453 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 532 (CSNK2B-LY6G5B-532 gene).
HE864454 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 560 (CSNK2B-LY6G5B-560 gene).
HE864455 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 562 (CSNK2B-LY6G5B-562 gene).
HE864456 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 696 (CSNK2B-LY6G5B-696 gene).
HE864457 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 991 (CSNK2B-LY6G5B--991 gene).
HE864459 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 1103 (CSNK2B-LY6G5B-1103 gene).
HE864460 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 1181 (CSNK2B-LY6G5B-1181 gene).
HE864461 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 1327 (CSNK2B-LY6G5B-1327 gene).
HE864458 - Homo sapiens mRNA for chimera CSNK2B-LY6G5B splicing isoform 1072 (CSNK2B-LY6G5B-1072 gene).

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04310 - Wnt signaling pathway
hsa04520 - Adherens junction
hsa04530 - Tight junction

+  Other Names for This Gene
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+  Gene Model Information
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+  Methods, Credits, and Use Restrictions
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