Human Gene PRRC2A (uc011gzg.2) Description and Page Index
Description: Homo sapiens proline-rich coiled-coil 2A (PRRC2A), transcript variant 2, mRNA. RefSeq Summary (NM_004638): A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]. Transcript (Including UTRs) Position: chr6_mann_hap4:2,931,334-2,948,438 Size: 17,105 Total Exon Count: 31 Strand: + Coding Region Position: chr6_mann_hap4:2,933,448-2,948,247 Size: 14,800 Coding Exon Count: 30
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Comments and Description Text from UniProtKB
ID:PRC2A_HUMAN DESCRIPTION: RecName: Full=Protein PRRC2A; AltName: Full=HLA-B-associated transcript 2; AltName: Full=Large proline-rich protein BAT2; AltName: Full=Proline-rich and coiled-coil-containing protein 2A; AltName: Full=Protein G2; FUNCTION: May play a role in the regulation of pre-mRNA splicing. INTERACTION: P54253:ATXN1; NbExp=4; IntAct=EBI-347545, EBI-930964; P05412:JUN; NbExp=2; IntAct=EBI-347545, EBI-852823; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Limited to cell-lines of leukemic origin. DEVELOPMENTAL STAGE: Broadly expressed during the 11th week of gestation, with highest levels in the central nervous system, spinal ganglia, osteoblasts and osteocytes (at protein level). SEQUENCE CAUTION: Sequence=AAA35585.1; Type=Frameshift; Positions=38, 58; Sequence=AAA35586.1; Type=Frameshift; Positions=38, 58; Sequence=BAE06116.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAA78744.1; Type=Frameshift; Positions=38, 58;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P48634
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.