Human Gene PRRC2A (uc011gzf.2) Description and Page Index
  Description: Homo sapiens proline-rich coiled-coil 2A (PRRC2A), transcript variant 1, mRNA.
RefSeq Summary (NM_080686): A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,931,334-2,948,438 Size: 17,105 Total Exon Count: 31 Strand: +
Coding Region
   Position: chr6_mann_hap4:2,933,448-2,948,247 Size: 14,800 Coding Exon Count: 30 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarrayRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Comments and Description Text from UniProtKB
  ID: PRC2A_HUMAN
DESCRIPTION: RecName: Full=Protein PRRC2A; AltName: Full=HLA-B-associated transcript 2; AltName: Full=Large proline-rich protein BAT2; AltName: Full=Proline-rich and coiled-coil-containing protein 2A; AltName: Full=Protein G2;
FUNCTION: May play a role in the regulation of pre-mRNA splicing.
INTERACTION: P54253:ATXN1; NbExp=4; IntAct=EBI-347545, EBI-930964; P05412:JUN; NbExp=2; IntAct=EBI-347545, EBI-852823;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Limited to cell-lines of leukemic origin.
DEVELOPMENTAL STAGE: Broadly expressed during the 11th week of gestation, with highest levels in the central nervous system, spinal ganglia, osteoblasts and osteocytes (at protein level).
SEQUENCE CAUTION: Sequence=AAA35585.1; Type=Frameshift; Positions=38, 58; Sequence=AAA35586.1; Type=Frameshift; Positions=38, 58; Sequence=BAE06116.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAA78744.1; Type=Frameshift; Positions=38, 58;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -122.90249-0.494 Picture PostScript Text
3' UTR -88.30191-0.462 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009738 - BAT2_N

Pfam Domains:
PF07001 - BAT2 N-terminus

ModBase Predicted Comparative 3D Structure on P48634
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  BC050408 - Homo sapiens, clone IMAGE:6197872, mRNA.
AB210034 - Homo sapiens mRNA for C6orf21 variant protein, partial cds, clone: hj06729.
AK309774 - Homo sapiens cDNA, FLJ99815.
AK302756 - Homo sapiens cDNA FLJ56810 complete cds, highly similar to Large proline-rich protein BAT2.
BC042295 - Homo sapiens HLA-B associated transcript 2, mRNA (cDNA clone MGC:48688 IMAGE:5555847), complete cds.
BC060668 - Homo sapiens HLA-B associated transcript 2, mRNA (cDNA clone MGC:57530 IMAGE:6471026), complete cds.
BC032134 - Homo sapiens HLA-B associated transcript 2, mRNA (cDNA clone IMAGE:4653409), partial cds.
M33509 - Human HLA-B-associated transcript 2 (BAT2) mRNA, complete cds.
AB384680 - Synthetic construct DNA, clone: pF1KB0056, Homo sapiens BAT2 gene for large proline-rich protein BAT2, complete cds, without stop codon, in Flexi system.
AF075059 - Homo sapiens full length insert cDNA YO70F05.
AK297210 - Homo sapiens cDNA FLJ56600 complete cds, highly similar to Large proline-rich protein BAT2.
CR749245 - Homo sapiens mRNA; cDNA DKFZp686D09175 (from clone DKFZp686D09175).
BC030127 - Homo sapiens, Similar to HLA-B associated transcript 2, clone IMAGE:3345434, mRNA, partial cds.
AK298584 - Homo sapiens cDNA FLJ56925 complete cds, highly similar to Large proline-rich protein BAT2.
DQ574007 - Homo sapiens piRNA piR-42119, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: B0UX77, B0UZE9, B0UZL3, BAT2, G2, NM_080686, NP_542417, O95875, P48634, PRC2A_HUMAN, Q05BK4, Q4LE37, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q8MGQ9, Q96QC6
UCSC ID: uc011gzf.2
RefSeq Accession: NM_080686
Protein: P48634 (aka PRC2A_HUMAN