Human Gene LST1 (uc011gys.2) Description and Page Index
Description: Homo sapiens leukocyte specific transcript 1 (LST1), transcript variant 2, mRNA. RefSeq Summary (NM_205837): The protein encoded by this gene is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. Transcript (Including UTRs) Position: chr6_mann_hap4:2,897,360-2,899,570 Size: 2,211 Total Exon Count: 4 Strand: + Coding Region Position: chr6_mann_hap4:2,897,961-2,899,246 Size: 1,286 Coding Exon Count: 3
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Comments and Description Text from UniProtKB
ID:LST1_HUMAN DESCRIPTION: RecName: Full=Leukocyte-specific transcript 1 protein; AltName: Full=Protein B144; FUNCTION: Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation. SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Note=Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm. TISSUE SPECIFICITY: Expressed in lung, tonsil, thymus, placenta, kidney, fetal spleen, fetal liver and brain. INDUCTION: By IFNG/IFN-gamma. Up-regulated upon autoimmune and bacterially-induced inflammation. SIMILARITY: Belongs to the LST1 family. SEQUENCE CAUTION: Sequence=AAX45332.1; Type=Erroneous termination; Positions=47; Note=Translated as Gln;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database: LST1 CDC HuGE Published Literature: LST1 Positive Disease Associations: Psoriasis Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00453
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
BX647293 - Homo sapiens mRNA; cDNA DKFZp781G1336 (from clone DKFZp781G1336). AF000425 - Homo sapiens LST1 mRNA, cLST1/A splice variant, complete cds. AF000424 - Homo sapiens LST1 mRNA, cLST1/C splice variant, complete cds. AF000426 - Homo sapiens LST1 mRNA, cLST1/E splice variant, complete cds. BC103855 - Homo sapiens leukocyte specific transcript 1, mRNA (cDNA clone MGC:119006 IMAGE:40003000), complete cds. BC103856 - Homo sapiens leukocyte specific transcript 1, mRNA (cDNA clone MGC:119007 IMAGE:40003004), complete cds. Y18486 - Homo sapiens mRNA for LST-1/J protein. Y18487 - Homo sapiens mRNA for LST-1/K protein. Y18488 - Homo sapiens mRNA for LST-1/L protein, partial. Y18489 - Homo sapiens mRNA for LST-1/M protein. Y18490 - Homo sapiens mRNA for LST-1/N protein. AY852265 - Homo sapiens LST1/O mRNA, complete cds, alternatively spliced. AY852266 - Homo sapiens LST1/P mRNA, complete cds, alternatively spliced. DQ099382 - Homo sapiens leukocyte specific transcript 1 mRNA, complete cds, alternatively spliced.