Human Gene LTA (uc011gyj.2) Description and Page Index
Description: Homo sapiens lymphotoxin alpha (TNF superfamily, member 1) (LTA), transcript variant 2, mRNA. RefSeq Summary (NM_000595): The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]. Transcript (Including UTRs) Position: chr6_mann_hap4:2,883,589-2,884,513 Size: 925 Total Exon Count: 2 Strand: +
Alzheimer's Disease Alvarez, V. et al. 2002, Association between the TNFalpha-308 A/G polymorphism and the onset-age of Alzheimer disease., American journal of medical genetics. 2002 Jul;114(5):574-7.
Our data suggest an effect of the TNFalpha-308 polymorphism on the age at onset of late AD. This represents additional evidence of the importance of genetic variation at the proinflammatory components in the origin and progression of this common NEUROLOGICALenerative disease.
Asthma Albuquerque R 1998, , Clinical and experimental allergy. 1998 May;28(5):578-84.
These results suggest an important role for the TNFalpha gene or a linked locus in an inherited asthma diathesis.
atherosclerosis, coronary Li, Y. et al. 2004, [Association between tumor necrosis factor-beta polymorphisms and coronary heart disease in a Chinese population.], Zhonghua yi xue yi chuan xue za zhi. 2004 Dec;21(6):583-6.
The single nucleotide polymorphism (SNP) at position 804 in the exon 3 of TNF-beta gene is associated with CHD and the allele A may be a risk factor for CHD in Chinese. The polymorphism of G252A may not play an important role in the pathogenesis of CHD.