Human Gene LTA (uc011gyg.2) Description and Page Index
  Description: Homo sapiens lymphotoxin alpha (TNF superfamily, member 1) (LTA), transcript variant 2, mRNA.
RefSeq Summary (NM_000595): The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,883,589-2,884,513 Size: 925 Total Exon Count: 2 Strand: +


Page IndexSequence and LinksGenetic AssociationsCTDMicroarrayOther Species
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Genetic Association Studies of Complex Diseases and Disorders
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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
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GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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+  Orthologous Genes in Other Species
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-  Descriptions from all associated GenBank mRNAs
  DQ123821 - Homo sapiens lymphotoxin alpha transcript variant 2 (LTA) mRNA, partial cds, alternatively spliced.
D12614 - Homo sapiens LT mRNA for lymphotoxin (TNF-beta), complete cds.
X01393 - Human mRNA for lymphotoxin.
D00102 - Homo sapiens mRNA for lymphotoxin, complete cds.
DQ894298 - Synthetic construct Homo sapiens clone IMAGE:100008758; FLH169474.01L; RZPDo839C1095D lymphotoxin alpha (TNF superfamily, member 1) (LTA) gene, encodes complete protein.
DQ891119 - Synthetic construct clone IMAGE:100003749; FLH169478.01X; RZPDo839C1096D lymphotoxin alpha (TNF superfamily, member 1) (LTA) gene, encodes complete protein.
BC034729 - Homo sapiens lymphotoxin alpha (TNF superfamily, member 1), mRNA (cDNA clone MGC:17018 IMAGE:4341621), complete cds.
AB590443 - Synthetic construct DNA, clone: pFN21AE1386, Homo sapiens LTA gene for lymphotoxin alpha, without stop codon, in Flexi system.
CU689954 - Synthetic construct Homo sapiens gateway clone IMAGE:100020241 5' read LTA mRNA.
CR542273 - Homo sapiens full open reading frame cDNA clone RZPDo834H0626D for gene LTA, lymphotoxin alpha (TNF superfamily, member 1); complete cds, without stopcodon.
CR542253 - Homo sapiens full open reading frame cDNA clone RZPDo834D0626D for gene LTA, lymphotoxin alpha (TNF superfamily, member 1); complete cds, incl. stopcodon.
E01275 - cDNA encoding human lymphotoxin polypeptide.
E01241 - cDNA encoding a polypeptide having a lymphotoxin activity.
E01481 - cDNA encoding human lymphotoxin.
E01482 - cDNA encoding human lymphotoxin.
E01804 - cDNA encoding human polypeptide having lymphotoxin activity.
A06316 - H.sapiens mRNA for lymphotoxin.
E01474 - cDNA encoding human lymphotoxin.
E01539 - DNA encoding lymphotoxin.
E02166 - DNA encoding human lympho toxin.
E02581 - Human lymphotoxin gene.
DQ123823 - Homo sapiens lymphotoxin alpha transcript variant 4 (LTA) mRNA, partial cds, alternatively spliced.
DQ123827 - Homo sapiens lymphotoxin alpha transcript variant 8 (LTA) mRNA, partial cds, alternatively spliced.
DQ123824 - Homo sapiens lymphotoxin alpha transcript variant 5 (LTA) mRNA, partial cds, alternatively spliced.
DQ123826 - Homo sapiens lymphotoxin alpha transcript variant 7 (LTA) mRNA, partial cds, alternatively spliced.
DQ123825 - Homo sapiens lymphotoxin alpha transcript variant 6 (LTA) mRNA, partial cds, alternatively spliced.
E01538 - DNA encoding lymphotoxin.
E03042 - DNA encoding improved human lymphotoxin.
E09028 - cDNA encoding novel recombinant lymphotoxin as antitumor agent.

+  Biochemical and Signaling Pathways
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+  Other Names for This Gene
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+  Gene Model Information
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+  Methods, Credits, and Use Restrictions
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