Human Gene LTA (uc011gye.2) Description and Page Index
  Description: Homo sapiens lymphotoxin alpha (TNF superfamily, member 1) (LTA), transcript variant 1, mRNA.
RefSeq Summary (NM_001159740): The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,882,760-2,884,984 Size: 2,225 Total Exon Count: 4 Strand: +
Coding Region
   Position: chr6_mann_hap4:2,883,404-2,884,354 Size: 951 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: LTA
CDC HuGE Published Literature: LTA
Positive Disease Associations: Alzheimer's Disease , Asthma , atherosclerosis, coronary , atopy , Behcet Syndrome , Brain Ischemia|Hypertension|Osteoporosis|Stroke , Chagas Cardiomyopathy , chronic immune thrombocytopenic purpura. , chronic obstructive pulmonary disease/COPD; bronchiectatic disease , complications after major abdominal operations , diabetes, type 1 , diabetes, type 2 , endometriosis , erythrocyte catalase activity , gastric cancer , hepatitis B , intima-media thickness , limb deficiency anomalies , Lupus , myelopathy, HTLV-1 associated , myocardial infarct , myocardial infarction , oral submucous fibrosis , palmoplantar pustulosis , Postoperative infectious complications , rheumatoid arthritis , sepsis , sepsis; serum tumor necrosis factor-alpha levels , testicular cancer , Tuberculosis , urinary tract infections after renal transplantation , Uveitis , vasopressor infusion requirement
Related Studies:
  1. Alzheimer's Disease
    Alvarez, V. et al. 2002, Association between the TNFalpha-308 A/G polymorphism and the onset-age of Alzheimer disease., American journal of medical genetics. 2002 Jul;114(5):574-7. [PubMed 12116197]
    Our data suggest an effect of the TNFalpha-308 polymorphism on the age at onset of late AD. This represents additional evidence of the importance of genetic variation at the proinflammatory components in the origin and progression of this common NEUROLOGICALenerative disease.
  2. Asthma
    Albuquerque R 1998, , Clinical and experimental allergy. 1998 May;28(5):578-84. [PubMed 9645594]
    These results suggest an important role for the TNFalpha gene or a linked locus in an inherited asthma diathesis.
  3. atherosclerosis, coronary
    Li, Y. et al. 2004, [Association between tumor necrosis factor-beta polymorphisms and coronary heart disease in a Chinese population.], Zhonghua yi xue yi chuan xue za zhi. 2004 Dec;21(6):583-6. [PubMed 15583987]
    The single nucleotide polymorphism (SNP) at position 804 in the exon 3 of TNF-beta gene is associated with CHD and the allele A may be a risk factor for CHD in Chinese. The polymorphism of G252A may not play an important role in the pathogenesis of CHD.
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+  Comparative Toxicogenomics Database (CTD)
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+  Microarray Expression Data
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+  mRNA Secondary Structure of 3' and 5' UTRs
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006053 - TNF
IPR002960 - TNF_beta
IPR021184 - TNF_CS
IPR006052 - TNF_dom
IPR008983 - Tumour_necrosis_fac-like_dom

Pfam Domains:
PF00229 - TNF(Tumour Necrosis Factor) family

SCOP Domains:
49842 - TNF-like

Protein Data Bank (PDB) 3-D Structure

1TNR
- X-ray Chimera LS-SNP

4MXV
- X-ray Chimera

4MXW
- X-ray Chimera
Chimera help

ModBase Predicted Comparative 3D Structure on P01374
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+  Orthologous Genes in Other Species
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+  Descriptions from all associated GenBank mRNAs
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-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04060 - Cytokine-cytokine receptor interaction
hsa04612 - Antigen processing and presentation
hsa04940 - Type I diabetes mellitus

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001159740, NP_001153212, P01374, Q8N4C3, Q9UKS8, TNFB, TNFB_HUMAN, TNFSF1, uc011gye.1
UCSC ID: uc011gye.2
RefSeq Accession: NM_001159740
Protein: P01374 (aka TNFB_HUMAN