Human Gene NFKBIL1 (uc011gyc.2) Description and Page Index
  Description: Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 (NFKBIL1), transcript variant 1, mRNA.
RefSeq Summary (NM_005007): This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,858,244-2,869,496 Size: 11,253 Total Exon Count: 4 Strand: +
Coding Region
   Position: chr6_mann_hap4:2,858,363-2,869,278 Size: 10,916 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: NFKBIL1
CDC HuGE Published Literature: NFKBIL1
Positive Disease Associations: Behcet Syndrome , diabetes, type 1 , myocardial infarct , ulcerative colitis
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  3. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.20119-0.455 Picture PostScript Text
3' UTR -78.30218-0.359 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

+  Protein Domain and Structure Information
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+  Orthologous Genes in Other Species
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-  Descriptions from all associated GenBank mRNAs
  AK300818 - Homo sapiens cDNA FLJ50875 complete cds, highly similar to NF-kappa-B inhibitor-like protein 1.
AK291893 - Homo sapiens cDNA FLJ76902 complete cds, highly similar to Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 (NFKBIL1), mRNA.
X77909 - H.sapiens IKBL mRNA.
BC105064 - Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1, mRNA (cDNA clone MGC:132724 IMAGE:8144067), complete cds.
BC105068 - Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1, mRNA (cDNA clone MGC:132728 IMAGE:8144071), complete cds.
BC143671 - Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1, mRNA (cDNA clone MGC:177202 IMAGE:9052185), complete cds.
AK313888 - Homo sapiens cDNA, FLJ94523.
AF097419 - Homo sapiens 10IHW 9022 IkBL protein (NFKBIL1) mRNA, NFKBIL1-+738T allele, complete cds.
AF097420 - Homo sapiens 4AOH 100044V IkBL protein (NFKBIL1) mRNA, NFKBIL1-+738T allele, complete cds.
AF097421 - Homo sapiens 10IHW 9082 IkBL protein (NFKBIL1) mRNA, NFKBIL1-+738C allele, complete cds.
AF097422 - Homo sapiens 10IHW 9013 IkBL protein (NFKBIL1) mRNA, NFKBIL1-+738C allele, complete cds.
AF097423 - Homo sapiens 10IHW 9052 IkBL protein (NFKBIL1) mRNA, NFKBIL1-+738T allele, complete cds.
AF097424 - Homo sapiens 4AOH 100083J IkBL protein (NFKBIL1) mRNA, NFKBIL1-+738T allele, complete cds.
AF097425 - Homo sapiens 10IHW 9090 IkBL protein (NFKBIL1) mRNA, NFKBIL1-+738T allele, complete cds.
AF097426 - Homo sapiens 10IHW 9027 IkBL protein (NFKBIL1) mRNA, NFKBIL1-+738T allele, complete cds.
AF097427 - Homo sapiens 10IHW 9041 IkBL protein (NFKBIL1) mRNA, NFKBIL1-+738T allele, complete cds.
AF097428 - Homo sapiens 10IHW 9006 IkBL protein (NFKBIL1) mRNA, NFKBIL1-+738T allele, complete cds.
AF097429 - Homo sapiens 4AOH 100108V IkBL protein (NFKBIL1) mRNA, NFKBIL1-+738T allele, complete cds.
AB527477 - Synthetic construct DNA, clone: pF1KB7638, Homo sapiens NFKBIL1 gene for nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1, without stop codon, in Flexi system.
EU446511 - Synthetic construct Homo sapiens clone IMAGE:100069892; IMAGE:100011720; FLH257083.01L nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 (NFKBIL1) gene, encodes complete protein.

+  Other Names for This Gene
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+  Gene Model Information
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+  Methods, Credits, and Use Restrictions
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