Human Gene ATP6V1G2 (uc011gxy.2) Description and Page Index
  Description: Homo sapiens ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 (ATP6V1G2), transcript variant 1, mRNA.
RefSeq Summary (NM_130463): This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of three V1 domain G subunit proteins. This gene had previous gene symbols of ATP6G and ATP6G2. Alternatively spliced transcript variants encoding different isoforms have been described. Read-through transcription also exists between this gene and the downstream DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (DDX39B) gene. [provided by RefSeq, Feb 2011].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,855,124-2,857,517 Size: 2,394 Total Exon Count: 3 Strand: -
Coding Region
   Position: chr6_mann_hap4:2,856,081-2,857,228 Size: 1,148 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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+  Genetic Association Studies of Complex Diseases and Disorders
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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -105.10289-0.364 Picture PostScript Text
3' UTR -216.50957-0.226 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

+  Protein Domain and Structure Information
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+  Orthologous Genes in Other Species
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-  Descriptions from all associated GenBank mRNAs
  BC004350 - Homo sapiens cDNA clone IMAGE:3536103.
BC068023 - Homo sapiens ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2, mRNA (cDNA clone IMAGE:6193921), partial cds.
BC047791 - Homo sapiens ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2, mRNA (cDNA clone IMAGE:6470215).
BC119726 - Homo sapiens ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2, mRNA (cDNA clone MGC:149758 IMAGE:40118129), complete cds.
BC119727 - Homo sapiens ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2, mRNA (cDNA clone MGC:149759 IMAGE:40118130), complete cds.

+  Biochemical and Signaling Pathways
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+  Other Names for This Gene
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+  Gene Model Information
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+  Methods, Credits, and Use Restrictions
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