Human Gene MICB (uc011gxg.2) Description and Page Index
  Description: Homo sapiens MHC class I polypeptide-related sequence B (MICB), mRNA.
RefSeq Summary (NM_005931): This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,514,269-2,821,820 Size: 307,552 Total Exon Count: 6 Strand: +
Coding Region
   Position: chr6_mann_hap4:2,816,341-2,820,607 Size: 4,267 Coding Exon Count: 5 

Page IndexSequence and LinksGenetic AssociationsCTDMicroarrayRNA Structure
Other SpeciesmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: MICB
CDC HuGE Published Literature: MICB
Positive Disease Associations: Behcet Syndrome , Dengue Hemorrhagic Fever , Diabetes Mellitus, Type 1 , Multiple Sclerosis , Neuroblastoma , Neutrophils , psoriasis , Respiratory Function Tests , rheumatoid arthritis , schizophrenia , Triglycerides , ulcerative colitis
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  3. Dengue Hemorrhagic Fever
    Chiea Chuen Khor et al. Nature genetics 2011, Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1., Nature genetics. [PubMed 22001756]
           more ... click here to view the complete list

+  Comparative Toxicogenomics Database (CTD)
  Press "+" in the title bar above to open this section.

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
Ratios
      
      
      
     
    
     
Absolute
      
       
      
      
     
    
Ratios
      
       
      
      
     
    
Absolute
   
     
     
Ratios
   
     
     
Absolute

+  mRNA Secondary Structure of 3' and 5' UTRs
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  AK300791 - Homo sapiens cDNA FLJ54659 complete cds, highly similar to Homo sapiens MHC class I polypeptide-related sequence B (MICB), mRNA.
GU235997 - Homo sapiens MHC class I chain-related molecule B (MICB) mRNA, partial cds, alternatively spliced.
AK303655 - Homo sapiens cDNA FLJ50341 complete cds, highly similar to Homo sapiens MHC class I polypeptide-related sequence B (MICB), mRNA.
X91625 - H.sapiens mRNA for MHC class I mic-B antigen.
CU677769 - Synthetic construct Homo sapiens gateway clone IMAGE:100019177 5' read MICA mRNA.
AY885251 - Homo sapiens MICB-like mRNA, complete sequence.
U95729 - Human MHC class I chain-related protein (MICB) mRNA, allele 2, partial cds.
U95730 - Human MHC class I chain-related protein (MICB) mRNA, allele 3, partial cds.
U95731 - Human MHC class I chain-related protein (MICB) mRNA, allele 4, partial cds.
U95732 - Human MHC class I chain-related protein (MICB) mRNA, allele 5, partial cds.
U95733 - Human MHC class I chain-related protein (MICB) mRNA, allele 6, partial cds.
U95734 - Human MHC class I chain-related protein (MICB) mRNA, allele 7, partial cds.
AK314228 - Homo sapiens cDNA, FLJ94967, Homo sapiens MHC class I polypeptide-related sequence B (MICB),mRNA.
AK291927 - Homo sapiens cDNA FLJ77775 complete cds, highly similar to Homo sapiens MHC class I polypeptide-related sequence B (MICB), mRNA.
BC044218 - Homo sapiens MHC class I polypeptide-related sequence B, mRNA (cDNA clone MGC:49933 IMAGE:6025253), complete cds.
AF021221 - Homo sapiens MHC class I chain-related protein B (MICB) mRNA, MICB-001 allele, partial cds.
AF021222 - Homo sapiens MHC class I chain-related protein B (MICB) mRNA, MICB-002 allele, partial cds.
AF021223 - Homo sapiens MHC class I chain-related protein B (MICB) mRNA, MICB-003 allele, partial cds.
AF021224 - Homo sapiens MHC class I chain-related protein B (MICB) mRNA, MICB-004 allele, partial cds.
AF021225 - Homo sapiens MHC class I chain-related protein B (MICB) mRNA, MICB-005 allele, partial cds.
AF021226 - Homo sapiens MHC class I chain-related protein B (MICB) mRNA, MICB-006 allele, partial cds.
FW573310 - JP 2010529847-A/31: Oligonucleotides for modulation of target RNA activity.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04650 - Natural killer cell mediated cytotoxicity

+  Other Names for This Gene
  Press "+" in the title bar above to open this section.

+  Gene Model Information
  Press "+" in the title bar above to open this section.

+  Methods, Credits, and Use Restrictions
  Press "+" in the title bar above to open this section.