Human Gene MICB (uc011gxf.2) Description and Page Index
  Description: Homo sapiens MHC class I polypeptide-related sequence B (MICB), mRNA.
RefSeq Summary (NM_005931): This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,717,805-2,821,820 Size: 104,016 Total Exon Count: 6 Strand: +
Coding Region
   Position: chr6_mann_hap4:2,717,844-2,820,607 Size: 102,764 Coding Exon Count: 6 

Page IndexSequence and LinksGenetic AssociationsCTDMicroarrayRNA Structure
Other SpeciesmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: MICB
CDC HuGE Published Literature: MICB
Positive Disease Associations: Behcet Syndrome , Dengue Hemorrhagic Fever , Diabetes Mellitus, Type 1 , Multiple Sclerosis , Neuroblastoma , Neutrophils , psoriasis , Respiratory Function Tests , rheumatoid arthritis , schizophrenia , Triglycerides , ulcerative colitis
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  3. Dengue Hemorrhagic Fever
    Chiea Chuen Khor et al. Nature genetics 2011, Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1., Nature genetics. [PubMed 22001756]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -11.3039-0.290 Picture PostScript Text
3' UTR -361.601213-0.298 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

+  Orthologous Genes in Other Species
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-  Descriptions from all associated GenBank mRNAs
  AK300791 - Homo sapiens cDNA FLJ54659 complete cds, highly similar to Homo sapiens MHC class I polypeptide-related sequence B (MICB), mRNA.
GU235997 - Homo sapiens MHC class I chain-related molecule B (MICB) mRNA, partial cds, alternatively spliced.
AK303655 - Homo sapiens cDNA FLJ50341 complete cds, highly similar to Homo sapiens MHC class I polypeptide-related sequence B (MICB), mRNA.
X91625 - H.sapiens mRNA for MHC class I mic-B antigen.
CU677769 - Synthetic construct Homo sapiens gateway clone IMAGE:100019177 5' read MICA mRNA.
BC016929 - Homo sapiens MHC class I polypeptide-related sequence A, mRNA (cDNA clone MGC:21250 IMAGE:4446575), complete cds.
AK225393 - Homo sapiens mRNA for MHC class I chain-related gene A protein variant, clone: HRC02220.
L14848 - Human MHC class I-related protein mRNA, complete cds.
AK299135 - Homo sapiens cDNA FLJ60820 complete cds, highly similar to Homo sapiens MHC class I polypeptide-related sequence A (MICA), mRNA.
AB590509 - Synthetic construct DNA, clone: pFN21AE1864, Homo sapiens MICA gene for MHC class I polypeptide-related sequence A, without stop codon, in Flexi system.
HQ447839 - Synthetic construct Homo sapiens clone IMAGE:100071183; CCSB001079_01 MHC class I polypeptide-related sequence A (MICA) gene, encodes complete protein.
AB506764 - Homo sapiens MICA mRNA for MHC class I chain-related protein A, complete cds.
AY204547 - Homo sapiens MHC class I related protein A (MICA) mRNA, MICA*001 variant allele, complete cds.
AY750850 - Homo sapiens MHC class I chain-related protein A (MICA) mRNA, MICA*00701 allele, complete cds.
AY885251 - Homo sapiens MICB-like mRNA, complete sequence.
U95729 - Human MHC class I chain-related protein (MICB) mRNA, allele 2, partial cds.
U95730 - Human MHC class I chain-related protein (MICB) mRNA, allele 3, partial cds.
U95731 - Human MHC class I chain-related protein (MICB) mRNA, allele 4, partial cds.
U95732 - Human MHC class I chain-related protein (MICB) mRNA, allele 5, partial cds.
U95733 - Human MHC class I chain-related protein (MICB) mRNA, allele 6, partial cds.
U95734 - Human MHC class I chain-related protein (MICB) mRNA, allele 7, partial cds.
AK314228 - Homo sapiens cDNA, FLJ94967, Homo sapiens MHC class I polypeptide-related sequence B (MICB),mRNA.
AK291927 - Homo sapiens cDNA FLJ77775 complete cds, highly similar to Homo sapiens MHC class I polypeptide-related sequence B (MICB), mRNA.
BC044218 - Homo sapiens MHC class I polypeptide-related sequence B, mRNA (cDNA clone MGC:49933 IMAGE:6025253), complete cds.
AF021221 - Homo sapiens MHC class I chain-related protein B (MICB) mRNA, MICB-001 allele, partial cds.
AF021222 - Homo sapiens MHC class I chain-related protein B (MICB) mRNA, MICB-002 allele, partial cds.
AF021223 - Homo sapiens MHC class I chain-related protein B (MICB) mRNA, MICB-003 allele, partial cds.
AF021224 - Homo sapiens MHC class I chain-related protein B (MICB) mRNA, MICB-004 allele, partial cds.
AF021225 - Homo sapiens MHC class I chain-related protein B (MICB) mRNA, MICB-005 allele, partial cds.
AF021226 - Homo sapiens MHC class I chain-related protein B (MICB) mRNA, MICB-006 allele, partial cds.
FW573310 - JP 2010529847-A/31: Oligonucleotides for modulation of target RNA activity.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04650 - Natural killer cell mediated cytotoxicity

+  Other Names for This Gene
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+  Gene Model Information
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+  Methods, Credits, and Use Restrictions
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