Human Gene HLA-B (uc011gwz.1) Description and Page Index
  Description: Homo sapiens major histocompatibility complex, class I, B (HLA-B), mRNA.
RefSeq Summary (NM_005514): HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK130169.1, BX647315.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084, ERS025087 [ECO:0000348] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,668,711-2,669,824 Size: 1,114 Total Exon Count: 3 Strand: -


Page IndexSequence and LinksGenetic AssociationsCTDMicroarrayOther Species
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

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+  Genetic Association Studies of Complex Diseases and Disorders
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-  Comparative Toxicogenomics Database (CTD)
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-  Microarray Expression Data
 
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GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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+  Orthologous Genes in Other Species
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-  Descriptions from all associated GenBank mRNAs
  M64258 - Human MHC class I HLA-B mRNA, partial cds.
X02494 - Human interferon-inducible mRNA (cDNA 2A) showing 90% homology with class I histocompatibility antigen.
M27540 - Human MHC class I HLA-A (A28,-B40,-Cw3) cell surface antigen mRNA, partial cds, clone LB40.
M64259 - Human MHC class I HLA-A mRNA, partial cds.
M64254 - Human MHC class I HLA-B mRNA, partial cds.
M64255 - Human MHC class I HLA-A mRNA, partial cds.
M64256 - Human MHC class I HLA-B mRNA, partial cds.
AF389378 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*3704 allele, complete cds.
AJ535113 - Homo sapiens mRNA for MHC class I antigen (HLA-B gene), HLA-B*44 allele.
AB008102 - Homo sapiens mRNA for HLA-B*5801, complete cds.
M24033 - Human MHC class I HLA-Bw46 mRNA (A2.4a; Bw46; Cw11), complete cds.
M32318 - Human MHC HLA protein, allele B57, complete cds.
Y09157 - H.sapiens mRNA for HLA-B antigen alpha chain (B*5703GB).
U11262 - Human isolate GU2037 HLA-B71 (B-1510) mRNA, partial cds.
U11264 - Human isolate GU2092 HLA-B71 (B-1510) mRNA, partial cds.
U11266 - Human isolate GU2739 HLA-B71 variant mRNA, partial cds.
U11268 - Human isolate GU2760 HLA-B71 variant mRNA, partial cds.
U11269 - Human HLA-B71 *1510 mRNA, partial cds.
AJ634528 - Homo sapiens partial mRNA for MHC class I antigen (HLA-B gene).
D64149 - Homo sapiens mRNA for HLA-Cw*1702, partial cds.
U74386 - Human MHC class I antigen HLA-B (HLA-B*0804 allele) mRNA, exons 2-4, partial cds.
U74387 - Human MHC class I antigen HLA-B (HLA-B*3911 allele) mRNA, exons 2-4, partial cds.
BC007243 - Homo sapiens, clone IMAGE:2966516, mRNA, partial cds.
AK130155 - Homo sapiens cDNA FLJ26645 fis, clone MPE03047, highly similar to HLA class I histocompatibility antigen, BW-75(B-15) B*1502 alpha chain precursor.
AK130654 - Homo sapiens cDNA FLJ27144 fis, clone SPL09358, highly similar to HLA class I histocompatibility antigen, B-35 B*3506 alpha chain precursor (B35-K).
AK124160 - Homo sapiens cDNA FLJ42166 fis, clone THYMU2019210, highly similar to HLA class I histocompatibility antigen, B-40 alpha chain precursor.
BC091497 - Homo sapiens MHC class I polypeptide-related sequence A, mRNA (cDNA clone MGC:111087 IMAGE:30386550), complete cds.
AY007140 - Homo sapiens clone CDABP0067 mRNA sequence.
BC013187 - Homo sapiens major histocompatibility complex, class I, B, mRNA (cDNA clone MGC:17189 IMAGE:4344323), complete cds.
AK026595 - Homo sapiens cDNA: FLJ22942 fis, clone KAT08170, highly similar to HUMMHBW62 Homo sapiens (clone pMF18) MHC class I HLA-Bw62 mRNA.
AK130169 - Homo sapiens cDNA FLJ26659 fis, clone MPE08671, highly similar to HLA class I histocompatibility antigen, B-40 B*4004 alpha chain precursor (B40-G2).
M28205 - Homo sapiens MHC class I HLA-B51 mRNA, complete cds, haplotype A2, B27/B51,Cw2/Cw3.
M28204 - Homo sapiens (clone pMF28) MHC class I HLA-Bw62 mRNA, 3' end, haplotype A1/A2,B8/Bw62,Cw3/Cw7.
M12678 - Human HLA-B27 mRNA, complete cds.
AK129796 - Homo sapiens cDNA FLJ26285 fis, clone DMC06816, highly similar to HLA class I histocompatibility antigen, BW-44(B-12) B*4402 alpha chain precursor (B44.2).
AK130137 - Homo sapiens cDNA FLJ26627 fis, clone MPC05094, highly similar to HLA class I histocompatibility antigen, B-35 B*3501 alpha chain precursor.
AK130166 - Homo sapiens cDNA FLJ26656 fis, clone MPE08287, highly similar to HLA class I histocompatibility antigen, B-40 B*4004 alpha chain precursor (B40-G2).
AK290570 - Homo sapiens cDNA FLJ78436 complete cds.
BX647315 - Homo sapiens mRNA; cDNA DKFZp686N10220 (from clone DKFZp686N10220).
BC013828 - Homo sapiens major histocompatibility complex, class I, B, mRNA (cDNA clone IMAGE:4148862).
D87665 - Homo sapiens heart mRNA for MHC class I HLA-Bw62, partial cds.
M15470 - Human MHC class I HLA-B44 mRNA, partial cds.
M28203 - Homo sapiens (clone pMF18) MHC class I HLA-Bw62 mRNA, 3' end, haplotype A1/A2,B8/Bw62,Cw3/Cw7.
AK300685 - Homo sapiens cDNA FLJ51097 complete cds, highly similar to HLA class I histocompatibility antigen, B-7alpha chain precursor.
AK292226 - Homo sapiens cDNA FLJ77663 complete cds, highly similar to Homo sapiens major histocompatibility complex, class I, B (HLA-B),mRNA.
U14943 - Human MHC antigen (HLA-B) mRNA, complete cds.
D49824 - Homo sapiens HLA-B null allele mRNA.
L42345 - Homo sapiens lymphocyte antigen HLA-B*4402 and HLA-B*5101 mRNA, exons 1-7, complete cds.
Z22651 - H.sapiens HLA-B35 mRNA.
Z33453 - H.sapiens mRNA for human leukocyte antigen HLA-B27.
L42024 - Homo sapiens MHC HLA-B39 mRNA, complete cds.
AF428252 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*3924-C183 allele, complete cds.
U63653 - Human MHC class I histocompatibility antigen HLA-B mRNA (HLA-B55 variant) mRNA, complete cds.
AF130734 - Homo sapiens HLA class I histocompatibility antigen B-57 (HLA-B57) mRNA, complete cds.
D83043 - Homo sapiens HLA-B mRNA, allele A*2711, complete cds.
M32317 - Homo sapiens HLA protein allele B7 mRNA, complete cds.
M32319 - Human MHC HLA protein, allele B51, complete cds.
M32320 - Human MHC HLA protein, allele B37, complete cds.
U88407 - Human MHC Class I antigen HLA-B (HLAB*4202 allele) mRNA, complete cds.
X81363 - H.sapiens mRNA for HLA-B*4102.
M84380 - Human MHC class I lymphocyte antigen (HLA-B*4801) mRNA, complete cds.
M84381 - Human MHC class I lymphocyte antigen (HLA-B*3506) mRNA, complete cds.
M84382 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*1504 allele, complete cds.
M84383 - Human MHC class I lymphocyte antigen (HLA-B*4003) mRNA, complete cds.
M84384 - Human MHC class I lymphocyte antigen (HLA-B*4004) mRNA, complete cds.
M84385 - Human MHC class I lymphocyte antigen (HLA-B*3505) mRNA, complete cds.
J00192 - human histocompatibility antigen mrna clone phla-1.
M62852 - Human MHC class I HLA-B27-HS mRNA, 3' end.
M83191 - Homo sapiens (isolate VB) HLA-Bw62 antigen (HLA-Bw62.1 IEF variant, B*1505 allele) mRNA, 3'end.
M83193 - Homo sapiens (isolate HA) HLA-Bw62 antigen (HLA-Bw62.3 IEF variant, B*1501 allele) mRNA, 3'end.
M83194 - Homo sapiens (isolate WI) HLA-Bw62 antigen (HLA-Bw62.4 IEF variant, B*1506 allele) mRNA, 3'end.
M83195 - Homo sapiens (isolate SB) HLA-Bw62 antigen (HLA-Bw62.5 IEF variant, B*1507 allele) mRNA, 3'end.
L20088 - Human MHC class I (HLA-B 3903) mRNA fragment.
L20090 - Human MHC class I (HLA-B 52012) mRNA fragment.
M86403 - Human MHC class I (HLA-B 3504) mRNA fragment.
L20086 - Human MHC class I (HLA-B 27052) mRNA fragment.
AF006634 - Homo sapiens histocompatibility antigen (hla-b) mRNA, partial cds.
AF026218 - Homo sapiens MHC class I antigen HLA-B (HLA-B27052 allele) mRNA, complete cds.
AF170577 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*3531 allele, complete cds.
AF189017 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*0718 allele, complete cds.
AF418978 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*3705 allele, complete cds.
AJ131118 - Homo sapiens mRNA for human leucocyte antigen B (HLA-B*44new gene).
AJ251593 - Homo sapiens mRNA for human leucocyte antigen B (HLA-B gene, HLA-B44Null allele).
AM711637 - Homo sapiens partial mRNA for HLA-B protein.
D25275 - Homo sapiens HLA-B18 mRNA, complete cds.
D31816 - Homo sapiens mRNA for HLA-B4007, complete cds.
D50290 - Homo sapiens mRNA for HLA-B*1301 antigen, complete cds.
D50291 - Homo sapiens mRNA for HLA-B*1302 antigen, complete cds.
D50292 - Homo sapiens mRNA for HLA-B*1501, complete cds.
D50294 - Homo sapiens mRNA for HLA-B*1511, complete cds.
D50295 - Homo sapiens mRNA for HLA-B*1513, complete cds.
D50299 - Homo sapiens mRNA for HLA-B35 antigen, complete cds.
D50300 - Homo sapiens mRNA for HLA-B*5901 antigen, complete cds.
D85761 - Homo sapiens HLA-B*5504 mRNA for HLA-B55.2, complete cds.
D85762 - Homo sapiens HLA-B*5603 mRNA for HLA-B22N, complete cds.
FM205711 - Homo sapiens partial mRNA for MHC class I antigen (HLA-B gene), HLA-B*350203 allele.
L04695 - Human MHC class I HLA-B35 (subtype B*3507) mRNA, complete cds.
L04696 - Human MHC class I HLA-B35 (subtype B*3508) mRNA, complete cds.
L07743 - Human MHC class I HLA-B-5901 gene mRNA, complete cds.
L09736 - Human MHC B*4002 mRNA, complete cds.
L11603 - Homo sapiens MHC class I HLA-B cell surface glycoprotein (subtype HLA-B1512) mRNA, complete cds.
L11604 - Homo sapiens MHC class I HLA-B cell surface glycoprotein (subtype HLA-B1511) mRNA, complete cds.
L11666 - Homo sapiens MHC class I HLA-B cell surface glycoprotein (subtype HLA-B*1508) mRNA, complete cds.
L15005 - Human transmembrane glycoprotein (HLA-B1513) mRNA, complete cds.
L17005 - Homo sapiens (clones 18.1, 18.3, 19.7, 19.10) HLA-B-6701 mRNA, complete cds.
L19923 - Homo sapiens MHC class I alpha chain (HLA-B) mRNA, complete cds.
L19937 - Homo sapiens MHC class I HLA-B*1514 mRNA, complete cds.
L22027 - Human MHC class I HLA-B 1515 mRNA, complete cds.
L22028 - Human MHC class I HLA-B*3802 mRNA, complete cds.
L36318 - Homo sapiens lymphocyte antigen MHC class I HLA-B-3905 gene, complete cds.
L36591 - Human MHC class I lymphocyte antigen (HLA-B 3801) mRNA, complete cds.
L37880 - Homo sapiens MHC class I HLA-B*8101 gene exons 1-8, complete cds.
L37881 - Homo sapiens MHC class I HLA-B*1523 mRNA, complete cds.
L38504 - Homo sapiens (clones 18.1, 18.2, 19.2) MHC class I HLA-B*2702 mRNA, complete cds.
L41214 - Homo sapiens MHC class I HLA-B*7802 mRNA, complete cds.
L41925 - Homo sapiens MHC HLA-B*51022 mRNA, complete cds.
M77774 - Human HLA-B*5401 mRNA, complete cds.
M77775 - Human HLA-B*5602 mRNA, complete cds.
M77776 - Human HLA-B*5601 mRNA, complete cds.
M77777 - Human HLA-B*5502 mRNA, complete cds.
M77778 - Human HLA-B*5501 mRNA, complete cds.
M81798 - Human MHC class I protein (HLA-B) mRNA, complete cds.
M84694 - Human MHC class I HLA-B*4005 mRNA, complete cds.
U01848 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*1517 allele, complete cds.
U03027 - Human cell line GEE018 (HLA B-1519) mRNA, complete cds.
U03698 - Human HLA B-40011 mRNA, complete cds.
U03859 - Human MHC Class I HLA-B-1501 mRNA, complete cds.
U04243 - Human MHC class I antigen HLA-B (HLA-B-39022 allele) mRNA, complete cds.
U04244 - Human MHC class I antigen HLA-B (HLA-B-0802 allele) mRNA, complete cds.
U09864 - Human HLA-B-1521 mRNA, complete cds.
U09912 - Human MHC class I histocompatibility antigen HLA-B (HLA-B-4803 allele) mRNA, complete cds.
U17107 - Human isolate MAP9 MHC class I antigen (HLA-B35) mRNA, complete cds.
U21053 - Human MHC class I antigen heavy chain HLA-B (HLA-B-0703) mRNA, complete cds.
U27608 - Human MHC class I antigen HLA-B (HLA-B-2704 allele) mRNA, complete cds.
U29057 - Human MHC class I antigen HLA-B7 variant (HLA-B) mRNA, complete cds.
U29083 - Homo sapiens MHC class I antigen (HLA-B) mRNA, complete cds.
U29480 - Human MHC class I antigen (HLA-B39) mRNA, complete cds.
U30904 - Human (HLA-B) mRNA, B-3515 allele, complete cds.
U30936 - Human MHC class I antigen HLA-B35 (B-3502new allele) mRNA, complete cds.
U31971 - Human MHC class I antigen HLA-B precursor (HLA-B) mRNA, complete cds.
U35431 - Human MHC class I antigen HLA-B (HLA-B-1517 allele) mRNA, complete cds.
U35734 - Human MHC class I antigen HLA-B alpha chain (HLA-B-2706 allele) mRNA, complete cds.
U36492 - Human MHC class I antigen (HLA-B) allele HLA-B-8201 mRNA, complete cds.
U38800 - Human HLA class I antigen (HLA-B), B-5602*new allele, mRNA, complete cds.
U40498 - Human MHC class I HLA-B38 mRNA, complete cds.
U70528 - Human MHC class I HLA-B*1504 mRNA, complete cds.
U75533 - Homo sapiens HLA class I antigen HLA-B mRNA (HLA-B*1303new allele), complete cds.
U80945 - Human MHC class I antigen (HLA-B) mRNA, allele HLA-B*1522, complete cds.
X61706 - Human RNA for HLA-Bw50 antigen.
X61707 - Human RNA for HLA-Bw57.2 antigen.
X61708 - Human RNA for HLA-Bw78 antigen.
X64366 - H.sapiens HLA-B*4403 mRNA for leucocyte antigen (HLA) class I molecule.
X64454 - H.sapiens mRNA for HLA-BPOT.
X73578 - H. sapiens HLA-B*2706 mRNA.
X84725 - H.sapiens mRNA for HLA-B alpha chain.
X90390 - H.sapiens mRNA for HLA-B antigen alpha chain (B*8101).
X90391 - H.sapiens mRNA for HLA-B antigen alpha chain (B*4407).
Y08995 - Homo sapiens mRNA for HLA-B antigen alpha chain (B*5002).
Y09058 - H.sapiens mRNA for HLA-B antigen alpha chain (B*39GB).
Z15143 - H.sapiens mRNA for MHC class I HLA-B*5104.
AK313911 - Homo sapiens cDNA, FLJ94549, Homo sapiens major histocompatibility complex, class I, B (HLA-B),mRNA.
DQ336696 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*1301 allele, partial cds.
AY221104 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*270502 variant allele, partial cds.
X75953 - H.sapiens HLA-B mRNA.
S42047 - membrane-bound HLA class I-B {clone SPC1, exons 4-7} [human, spleen, mRNA Partial, 235 nt].
S55521 - MHC class I-like alpha chain membrane-bound type [human, renal cell carcinoma, mRNA Partial, 235 nt].
M64253 - Human MHC class I HLA-A mRNA, partial cds.
M64257 - Human MHC class I HLA-A mRNA, partial cds.
AF022783 - Homo sapiens MHC class I histocompatibility antigen HLA-B mRNA, partial cds.
U11261 - Human HLA-B50 (B-5001) mRNA, partial cds.
U11263 - Human HLA-B49 (B-4901) mRNA, partial cds.
U11265 - Human HLA-B35 (B-3501) mRNA, partial cds.
U17572 - Human MHC class I HLA-B41 variant mRNA, partial cds.
D14343 - Homo sapiens HLA-B61 mRNA, partial cds.
Y09118 - H.sapiens mRNA for human leukocyte antigen B (HLA-B*47 variant).
AY569160 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*35 variant allele, partial cds.
U06697 - Human clone C21/14 MHC class I histocompatibility antigen (HLA-B) mRNA, partial cds.
V00527 - Human mRNA fragment for the histocompatibility antigen (HLA-B).
DQ336697 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*4801 allele, partial cds.
AK301008 - Homo sapiens cDNA FLJ52207 complete cds, highly similar to HLA class I histocompatibility antigen, B-7 alpha chain precursor.
AK309345 - Homo sapiens cDNA, FLJ99386.
AK303541 - Homo sapiens cDNA FLJ53569 complete cds, moderately similar to HLA class I histocompatibility antigen, B-8 alpha chain precursor.
E01342 - cDNA encoding C-terminal Fragment of HLA-B27.
AM261441 - Homo sapiens mRNA for MHC class I antigen (HLA-B gene), HLA-B*3565Q allele.
GQ141863 - Homo sapiens MHC class I antigen (HLA-B) gene, HLA-B*13 new allele, complete cds.
HE663398 - Homo sapiens partial mRNA for MHC class I antigen (HLA-B gene), allele HLA-B*35 variant.
HG327115 - Homo sapiens mRNA for MHC class I antigen (HLA-B gene), isolate 4388, allele HLA-B*27:17.
HG327119 - Homo sapiens mRNA for MHC class I antigen (HLA-B gene), isolate 20193, allele HLA-B*56:07.
HG327120 - Homo sapiens mRNA for MHC class I antigen (HLA-B gene), isolate 21871, allele HLA-B*35:42:01.
HG327121 - Homo sapiens mRNA for MHC class I antigen (HLA-B gene), isolate 23293, allele HLA-B*14:06:01.
HG327122 - Homo sapiens mRNA for MHC class I antigen (HLA-B gene), isolate 34873, allele HLA-B*27:10.
EU668336 - Homo sapiens epididymis secretory protein Li 83 (HEL-S-83) mRNA, complete cds.

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