Human Gene HLA-C (uc011gww.1) Description and Page Index
  Description: Homo sapiens major histocompatibility complex, class I, C (HLA-C), transcript variant 1, mRNA.
RefSeq Summary (NM_002117): HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,585,739-2,671,188 Size: 85,450 Total Exon Count: 2 Strand: -
Coding Region
   Position: chr6_mann_hap4:2,585,740-2,671,156 Size: 85,417 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Comments and Description Text from UniProtKB
  ID: Q30194_HUMAN
DESCRIPTION: SubName: Full=MHC class I protein HLA-C heavy chain; Flags: Fragment;
SIMILARITY: Belongs to the MHC class I family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: HLA-C
CDC HuGE Published Literature: HLA-C
Positive Disease Associations: AIDS progression , Arthritis, Psoriatic , Behcet Syndrome , Diabetes Mellitus, Type 1 , diabetes, type 1 , endometriosis , HIV-1 control , Leprosy , Lupus , Multiple Sclerosis , periodontitis , protein quantitative trait loci , psoriasis , psoriatic arthritis , vitiligo
Related Studies:
  1. AIDS progression
    Limou ,et al. 2009, Genomewide Association Study of an AIDS-Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02)., The Journal of infectious diseases 2009 199- 3 : 419-26. [PubMed 19115949]
  2. Arthritis, Psoriatic
    Marketa Fojtikova , et al. Rheumatology international 2009 29(11):1293-9, HLA-Cw*06 class I region rather than MICA is associated with psoriatic arthritis in Czech population., Rheumatology international 2009 29(11):1293-9. [PubMed 19184033]
  3. Arthritis, Psoriatic
    Ulrike Huffmeier et al. Nature genetics 2010, Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis., Nature genetics. [PubMed 20953186]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -2.1032-0.066 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011161 - MHC_I-like_Ag-recog
IPR011162 - MHC_I/II-like_Ag-recog
IPR027648 - MHC_I_a
IPR001039 - MHC_I_a_a1/a2

Pfam Domains:
PF00129 - Class I Histocompatibility antigen, domains alpha 1 and 2

SCOP Domains:
54452 - MHC antigen-recognition domain

ModBase Predicted Comparative 3D Structure on Q30194
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Jackson Lab     
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  X86703 - H.sapiens mRNA for heavy chain of HLA-B gene, HLA-B*5802.
AK130592 - Homo sapiens cDNA FLJ27082 fis, clone SPL03377.
M27540 - Human MHC class I HLA-A (A28,-B40,-Cw3) cell surface antigen mRNA, partial cds, clone LB40.
L20089 - Human MHC class I (HLA-B 4802) mRNA fragment.
AJ440716 - Homo sapiens partial mRNA for MHC class I antigen (HLA-C gene, HLA-Cw*07 allele), exons 2 and 3.
D83029 - Homo sapiens mRNA for HLA-Cw*2, partial cds.
D83030 - Homo sapiens HLA-Cw*04011 mRNA for MHC class I antigen, partial cds.
Z47377 - H.sapiens HLA-Cw gene (exon 2-4).
FN662479 - Homo sapiens partial mRNA for MHC class I antigen (HLA-C gene), allele HLA-Cw*01new.
AJ223602 - Homo sapiens HLA-B*07 variant (B*07AE), exons 2 and 3, isolate 980043.
M26429 - Human MHC class I HLA-Cw1 gene, complete cds.
M26430 - Human MHC class I HLA-Cw2 gene, complete cds.
BC010542 - Homo sapiens, clone IMAGE:3459298, mRNA, partial cds.
BC002463 - Homo sapiens major histocompatibility complex, class I, C, mRNA (cDNA clone MGC:2285 IMAGE:3345005), complete cds.
BC004489 - Homo sapiens major histocompatibility complex, class I, C, mRNA (cDNA clone IMAGE:3678099), partial cds.
BC033293 - Homo sapiens major histocompatibility complex, class I, C, mRNA (cDNA clone MGC:24960 IMAGE:4780246), complete cds.
AK024836 - Homo sapiens cDNA: FLJ21183 fis, clone CAS11634, highly similar to HSHLACW07 Homo sapiens mRNA for human leukocyte antigen C alpha chain.
BC041078 - Homo sapiens major histocompatibility complex, class I, C, mRNA (cDNA clone IMAGE:5926397), containing frame-shift errors.
M28206 - Homo sapiens (clone pMS1) MHC class I HLA-Cw6 mRNA, 3' end, haplotype A2/A30,B13,Cw6.
M26712 - Human major histocompatibility class I HLA-Cw2.2 heavy chain mRNA, partial cds.
AK304527 - Homo sapiens cDNA FLJ53134 complete cds, highly similar to HLA class I histocompatibility antigen, Cw-7alpha chain precursor.
BC007814 - Homo sapiens major histocompatibility complex, class I, C, mRNA (cDNA clone IMAGE:4299697), partial cds.
X58536 - Human mRNA for HLA class I locus C heavy chain.
BC008457 - Homo sapiens major histocompatibility complex, class I, C, mRNA (cDNA clone MGC:14707 IMAGE:4249847), complete cds.
M24096 - Human MHC class I HLA-C-alpha-2 chain mRNA, partial cds, clone 9.
M24097 - Human MHC class I HLA-C-alpha-2 chain and alternative mRNA, complete cds, clones 4 and 10.
M28207 - Homo sapiens (clone pMF17) MHC class I HLA-Cw7 mRNA, 3' end, haplotype A1/A2,B8/Bw62,Cw3/Cw7.
M11886 - Human MHC class I HLA-C allele HLA-4, partial cds.
M28160 - Human lymphocyte antigen (HLA CW6) JTW1 mRNA, complete cds, clone JTW1.
M21963 - Human (clone pC68) MHC class I HLA-Cx52 mRNA, 3' end cds.
D12471 - Homo sapiens mRNA for HLA-Cw12, complete cds, allele: HLA-C (Cw*1201).
M12679 - Human Cw1 antigen mRNA, complete cds.
AF196489 - Homo sapiens MHC class I antigen (HLA-C) mRNA, HLA-C-Cw*0409 N allele, complete cds.
AF405691 - Homo sapiens MHC class I antigen heavy chain (HLA-CW) mRNA, HLA-CW*04null allele, complete cds.
AK301283 - Homo sapiens cDNA FLJ54183 complete cds, highly similar to HLA class I histocompatibility antigen, Cw-7 alpha chain precursor.
X67818 - H.sapiens mRNA for HLA-Cw*1502.
X70856 - H.sapiens mRNA for HLA-Cw*12022.
X70857 - H.sapiens mRNA for HLA-Cw*0602.
M24031 - Human MHC class I HLA-Cw11 chain mRNA (A2.4a; B27; Cw11), 3' end.
AB590141 - Synthetic construct DNA, clone: pFN21AE1509, Homo sapiens HLA-C gene for major histocompatibility complex, class I, C, without stop codon, in Flexi system.
AF168611 - Homo sapiens HLA-C class I antigen (HLA-C) mRNA, HLA-Cw*05DZ allele, complete cds.
AJ010748 - Homo sapiens mRNA for HLA-C class I antigen, allele HLA-Cw*050x.
AJ010749 - Homo sapiens mRNA for HLA-C class I antigen, allele HLA-Cw*070x.
AY732487 - Homo sapiens MHC class I antigen (HLA-C) mRNA, complete cds.
D31817 - Homo sapiens mRNA for HLA-C antigen, complete cds.
D38526 - Homo sapiens mRNA for HLA-Cw*0702, complete cds.
D49552 - Homo sapiens mRNA for HLA-Cw*0704, complete cds.
D49819 - Homo sapiens mRNA for HLA-Cw*0702, complete cds.
D50852 - Homo sapiens HLA-Cw*0102 mRNA for MHC class I antigen, complete cds.
D50853 - Homo sapiens HLA-Cw*0303 mRNA for MHC class I antigen, complete cds.
D50854 - Homo sapiens HLA-Cw*0803 mRNA for MHC class I antigen, complete cds.
D64145 - Homo sapiens mRNA for HLA-Cw*0103, complete cds.
D83031 - Homo sapiens HLA-Cw*1502 mRNA for MHC class I antigen, complete cds.
DQ891896 - Synthetic construct clone IMAGE:100004526; FLH181216.01X; RZPDo839B01136D major histocompatibility complex, class I, C (HLA-C) gene, encodes complete protein.
DQ895082 - Synthetic construct Homo sapiens clone IMAGE:100009542; FLH181212.01L; RZPDo839B01135D major histocompatibility complex, class I, C (HLA-C) gene, encodes complete protein.
L38251 - Homo sapiens major histocompatibility complex class I (HLAC) mRNA, complete cds.
M84171 - Human MHC class I (HLA-Cw1.2) mRNA exons 1-7, complete cds.
M84173 - Human MHC class I (HLA-Cw8.2) mRNA exons 1-7, complete cds.
M84174 - Human MHC class I (HLA-Cw8.1) mRNA exons 1-7, complete cds.
M84386 - Human MHC class I lymphocyte antigen (HLA-Cw*0401) mRNA, 5' end.
M99388 - Homo sapiens HLA class I heavy chain (HLA-Cw-1503) mRNA, complete cds.
M99389 - Human MHC class I HLA heavy chain (HLA-Cw-0304) mRNA, complete cds.
M99390 - Human MHC class I HLA heavy chain (HLA-Cw-0303) mRNA, complete cds.
U06487 - Human clone LUY 2/12 MHC class I histocompatibility antigen (HLA-Cw) mRNA, complete cds.
U06695 - Human clone WDV 14/16 MHC class I histocompatibility antigen (HLA-Cw) mRNA, complete cds.
U06696 - Human clone DO208915 6/7 MHC class I histocompatibility antigen (HLA-Cw) mRNA, complete cds.
U09853 - Homo sapiens HLA-Cw7 mRNA, complete cds.
U41386 - Homo sapiens MHC class I antigen HLA-C mRNA (HLA-Cw-1402 allele), complete cds.
U41420 - Homo sapiens MHC class I antigen HLA-C mRNA (HLA-Cw-1603 allele), complete cds.
U57028 - Human HLA class I antigen HLA-Cw mRNA (HLA-Cw*0501new allele), complete cds.
U62824 - Homo sapiens HLA class I heavy chain (HLA-Cw*1701) mRNA, complete cds.
X73518 - H.sapiens mRNA for HLA-C alpha chain (Cw*1504).
X76189 - H. sapiens HLA-Cw*1602 mRNA.
X78343 - H.sapiens mRNA for HLA-Cw*1505.
X82122 - H.sapiens mRNA for HLA-Cw*1203.
X87841 - H.sapiens mRNA for HLA-C alpha chain (allele Cw*15052).
X96582 - H.sapiens mRNA for HLA-C alpha chain.
X97321 - H.sapiens mRNA for human leukocyte antigen C alpha chain.
X98742 - H.sapiens mRNA for HLA-C alpha chain (Cw*17).
Y09156 - H.sapiens mRNA for HLA-C antigen alpha chain (Cw*18GB).
Y10520 - H.sapiens mRNA for HLA-C alpha chain (Cw*1701).
Y11843 - H.sapiens mRNA for MHC class I human leukocyte antigen, allele HLA-Cw*12042.
Z15144 - H.sapiens mRNA for MHC class I HLA-Cw*0803 (partial).
Z83247 - H.sapiens mRNA for human leukocyte antigen-C (allele Cw*1205).
X83394 - H.sapiens mRNA for HLA-Cw*0704.
L20091 - Human MHC class I (HLA-C w1502) mRNA fragment.
D49820 - Homo sapiens Cw*1402 mRNA for MHC class I antigen, partial cds.
AM237285 - Homo sapiens partial mRNA for MHC class I antigen (HLA-C gene), HLA-Cw*07x05 hybrid allele.
D64146 - Homo sapiens mRNA for HLA-Cw*1203, partial cds.
D64147 - Homo sapiens mRNA for HLA-Cw*0602, partial cds.
D64148 - Homo sapiens mRNA for HLA-Cw5, partial cds.
D64150 - Homo sapiens mRNA for HLA-Cw*0304, partial cds.
D64151 - Homo sapiens mRNA for HLA-Cw*0801, partial cds.
D64152 - Homo sapiens mRNA for HLA-Cw*12022, partial cds.
U06835 - Human clone RSH 34 MHC class I HLA-Cw mRNA, partial cds.
Z33459 - H.sapiens mRNA for MHC class I HLA-C allele.
CU675811 - Synthetic construct Homo sapiens gateway clone IMAGE:100023339 5' read HLA-C mRNA.
U07230 - Human MHC class I HLA-Cw mRNA, partial cds.
AJ005199 - Homo sapiens HLA-Cw*03MAC gene, exons 2 and 3.
D83741 - Homo sapiens HLA-Cw*12022 mRNA for MHC class I antigen, partial cds.
HM989018 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*55 variant allele, partial cds.
Z46809 - H.sapiens HLA-Cw*0102 mRNA for HLA-Cw1.
AJ537578 - Homo sapiens partial mRNA for MHC class I antigen (HLA-C gene), HLA-Cw*16 allele.
Z46810 - H.sapiens HLA-Cw*0701 mRNA for HLA-Cw7.
DQ580344 - Homo sapiens piRNA piR-48456, complete sequence.
JN887337 - Homo sapiens MHC class I antigen (HLA-C) mRNA, HLA-C08:22-like allele, partial cds.
HG327117 - Homo sapiens mRNA for MHC class I antigen (HLA-B gene), isolate 12762, allele HLA-B*55:11.
AF389378 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*3704 allele, complete cds.
AJ535113 - Homo sapiens mRNA for MHC class I antigen (HLA-B gene), HLA-B*44 allele.
AB008102 - Homo sapiens mRNA for HLA-B*5801, complete cds.
M24033 - Human MHC class I HLA-Bw46 mRNA (A2.4a; Bw46; Cw11), complete cds.
M32318 - Human MHC HLA protein, allele B57, complete cds.
Y09157 - H.sapiens mRNA for HLA-B antigen alpha chain (B*5703GB).
U11262 - Human isolate GU2037 HLA-B71 (B-1510) mRNA, partial cds.
U11264 - Human isolate GU2092 HLA-B71 (B-1510) mRNA, partial cds.
U11266 - Human isolate GU2739 HLA-B71 variant mRNA, partial cds.
U11268 - Human isolate GU2760 HLA-B71 variant mRNA, partial cds.
U11269 - Human HLA-B71 *1510 mRNA, partial cds.
AJ634528 - Homo sapiens partial mRNA for MHC class I antigen (HLA-B gene).
U74386 - Human MHC class I antigen HLA-B (HLA-B*0804 allele) mRNA, exons 2-4, partial cds.
U74387 - Human MHC class I antigen HLA-B (HLA-B*3911 allele) mRNA, exons 2-4, partial cds.
L47986 - Homo sapiens major histocompatibility complex class I (HLA-B*3504) mRNA, partial cds.
L63544 - Homo sapiens lymphocyte antigen (HLA-B*3501) mRNA, partial cds.
L76930 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*3505 allele, partial cds.
L76933 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B-B*3501 allele, partial cds.
U32678 - Human MHC class I antigen HLA-B (HLA-B-1521 allele) mRNA, partial cds.
AF436090 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*15011 allele, partial cds.
AF436092 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*35011 allele, partial cds.
AF436093 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*3504 allele, partial cds.
U18660 - Human MHC class I HLA-B mRNA (HLA-B-15AOH allele) exons 2 and 3, partial cds.
BC007243 - Homo sapiens, clone IMAGE:2966516, mRNA, partial cds.
AK130155 - Homo sapiens cDNA FLJ26645 fis, clone MPE03047, highly similar to HLA class I histocompatibility antigen, BW-75(B-15) B*1502 alpha chain precursor.
AK130654 - Homo sapiens cDNA FLJ27144 fis, clone SPL09358, highly similar to HLA class I histocompatibility antigen, B-35 B*3506 alpha chain precursor (B35-K).
AK124160 - Homo sapiens cDNA FLJ42166 fis, clone THYMU2019210, highly similar to HLA class I histocompatibility antigen, B-40 alpha chain precursor.
BC091497 - Homo sapiens MHC class I polypeptide-related sequence A, mRNA (cDNA clone MGC:111087 IMAGE:30386550), complete cds.
AY007140 - Homo sapiens clone CDABP0067 mRNA sequence.
BC013187 - Homo sapiens major histocompatibility complex, class I, B, mRNA (cDNA clone MGC:17189 IMAGE:4344323), complete cds.
AK026595 - Homo sapiens cDNA: FLJ22942 fis, clone KAT08170, highly similar to HUMMHBW62 Homo sapiens (clone pMF18) MHC class I HLA-Bw62 mRNA.
AK130169 - Homo sapiens cDNA FLJ26659 fis, clone MPE08671, highly similar to HLA class I histocompatibility antigen, B-40 B*4004 alpha chain precursor (B40-G2).
M28205 - Homo sapiens MHC class I HLA-B51 mRNA, complete cds, haplotype A2, B27/B51,Cw2/Cw3.
M28204 - Homo sapiens (clone pMF28) MHC class I HLA-Bw62 mRNA, 3' end, haplotype A1/A2,B8/Bw62,Cw3/Cw7.
M12678 - Human HLA-B27 mRNA, complete cds.
AK129796 - Homo sapiens cDNA FLJ26285 fis, clone DMC06816, highly similar to HLA class I histocompatibility antigen, BW-44(B-12) B*4402 alpha chain precursor (B44.2).
AK130137 - Homo sapiens cDNA FLJ26627 fis, clone MPC05094, highly similar to HLA class I histocompatibility antigen, B-35 B*3501 alpha chain precursor.
AK130166 - Homo sapiens cDNA FLJ26656 fis, clone MPE08287, highly similar to HLA class I histocompatibility antigen, B-40 B*4004 alpha chain precursor (B40-G2).
AK290570 - Homo sapiens cDNA FLJ78436 complete cds.
BX647315 - Homo sapiens mRNA; cDNA DKFZp686N10220 (from clone DKFZp686N10220).
D87665 - Homo sapiens heart mRNA for MHC class I HLA-Bw62, partial cds.
M15470 - Human MHC class I HLA-B44 mRNA, partial cds.
M28203 - Homo sapiens (clone pMF18) MHC class I HLA-Bw62 mRNA, 3' end, haplotype A1/A2,B8/Bw62,Cw3/Cw7.
AK300685 - Homo sapiens cDNA FLJ51097 complete cds, highly similar to HLA class I histocompatibility antigen, B-7alpha chain precursor.
AK292226 - Homo sapiens cDNA FLJ77663 complete cds, highly similar to Homo sapiens major histocompatibility complex, class I, B (HLA-B),mRNA.
U14943 - Human MHC antigen (HLA-B) mRNA, complete cds.
D49824 - Homo sapiens HLA-B null allele mRNA.
L42345 - Homo sapiens lymphocyte antigen HLA-B*4402 and HLA-B*5101 mRNA, exons 1-7, complete cds.
Z22651 - H.sapiens HLA-B35 mRNA.
Z33453 - H.sapiens mRNA for human leukocyte antigen HLA-B27.
L42024 - Homo sapiens MHC HLA-B39 mRNA, complete cds.
AF428252 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*3924-C183 allele, complete cds.
U63653 - Human MHC class I histocompatibility antigen HLA-B mRNA (HLA-B55 variant) mRNA, complete cds.
AF130734 - Homo sapiens HLA class I histocompatibility antigen B-57 (HLA-B57) mRNA, complete cds.
D83043 - Homo sapiens HLA-B mRNA, allele A*2711, complete cds.
M32317 - Homo sapiens HLA protein allele B7 mRNA, complete cds.
M32319 - Human MHC HLA protein, allele B51, complete cds.
M32320 - Human MHC HLA protein, allele B37, complete cds.
U88407 - Human MHC Class I antigen HLA-B (HLAB*4202 allele) mRNA, complete cds.
X81363 - H.sapiens mRNA for HLA-B*4102.
M84380 - Human MHC class I lymphocyte antigen (HLA-B*4801) mRNA, complete cds.
M84381 - Human MHC class I lymphocyte antigen (HLA-B*3506) mRNA, complete cds.
M84382 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*1504 allele, complete cds.
M84383 - Human MHC class I lymphocyte antigen (HLA-B*4003) mRNA, complete cds.
M84384 - Human MHC class I lymphocyte antigen (HLA-B*4004) mRNA, complete cds.
M84385 - Human MHC class I lymphocyte antigen (HLA-B*3505) mRNA, complete cds.
M62852 - Human MHC class I HLA-B27-HS mRNA, 3' end.
M83191 - Homo sapiens (isolate VB) HLA-Bw62 antigen (HLA-Bw62.1 IEF variant, B*1505 allele) mRNA, 3'end.
M83193 - Homo sapiens (isolate HA) HLA-Bw62 antigen (HLA-Bw62.3 IEF variant, B*1501 allele) mRNA, 3'end.
M83194 - Homo sapiens (isolate WI) HLA-Bw62 antigen (HLA-Bw62.4 IEF variant, B*1506 allele) mRNA, 3'end.
M83195 - Homo sapiens (isolate SB) HLA-Bw62 antigen (HLA-Bw62.5 IEF variant, B*1507 allele) mRNA, 3'end.
L20088 - Human MHC class I (HLA-B 3903) mRNA fragment.
L20090 - Human MHC class I (HLA-B 52012) mRNA fragment.
M86403 - Human MHC class I (HLA-B 3504) mRNA fragment.
L20086 - Human MHC class I (HLA-B 27052) mRNA fragment.
AF006634 - Homo sapiens histocompatibility antigen (hla-b) mRNA, partial cds.
AF026218 - Homo sapiens MHC class I antigen HLA-B (HLA-B27052 allele) mRNA, complete cds.
AF170577 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*3531 allele, complete cds.
AF189017 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*0718 allele, complete cds.
AF418978 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*3705 allele, complete cds.
AJ131118 - Homo sapiens mRNA for human leucocyte antigen B (HLA-B*44new gene).
AJ251593 - Homo sapiens mRNA for human leucocyte antigen B (HLA-B gene, HLA-B44Null allele).
AM711637 - Homo sapiens partial mRNA for HLA-B protein.
D25275 - Homo sapiens HLA-B18 mRNA, complete cds.
D31816 - Homo sapiens mRNA for HLA-B4007, complete cds.
D50290 - Homo sapiens mRNA for HLA-B*1301 antigen, complete cds.
D50291 - Homo sapiens mRNA for HLA-B*1302 antigen, complete cds.
D50292 - Homo sapiens mRNA for HLA-B*1501, complete cds.
D50294 - Homo sapiens mRNA for HLA-B*1511, complete cds.
D50295 - Homo sapiens mRNA for HLA-B*1513, complete cds.
D50299 - Homo sapiens mRNA for HLA-B35 antigen, complete cds.
D50300 - Homo sapiens mRNA for HLA-B*5901 antigen, complete cds.
D85761 - Homo sapiens HLA-B*5504 mRNA for HLA-B55.2, complete cds.
D85762 - Homo sapiens HLA-B*5603 mRNA for HLA-B22N, complete cds.
FM205711 - Homo sapiens partial mRNA for MHC class I antigen (HLA-B gene), HLA-B*350203 allele.
L04695 - Human MHC class I HLA-B35 (subtype B*3507) mRNA, complete cds.
L04696 - Human MHC class I HLA-B35 (subtype B*3508) mRNA, complete cds.
L07743 - Human MHC class I HLA-B-5901 gene mRNA, complete cds.
L09736 - Human MHC B*4002 mRNA, complete cds.
L11603 - Homo sapiens MHC class I HLA-B cell surface glycoprotein (subtype HLA-B1512) mRNA, complete cds.
L11604 - Homo sapiens MHC class I HLA-B cell surface glycoprotein (subtype HLA-B1511) mRNA, complete cds.
L11666 - Homo sapiens MHC class I HLA-B cell surface glycoprotein (subtype HLA-B*1508) mRNA, complete cds.
L15005 - Human transmembrane glycoprotein (HLA-B1513) mRNA, complete cds.
L17005 - Homo sapiens (clones 18.1, 18.3, 19.7, 19.10) HLA-B-6701 mRNA, complete cds.
L19923 - Homo sapiens MHC class I alpha chain (HLA-B) mRNA, complete cds.
L19937 - Homo sapiens MHC class I HLA-B*1514 mRNA, complete cds.
L22027 - Human MHC class I HLA-B 1515 mRNA, complete cds.
L22028 - Human MHC class I HLA-B*3802 mRNA, complete cds.
L36318 - Homo sapiens lymphocyte antigen MHC class I HLA-B-3905 gene, complete cds.
L36591 - Human MHC class I lymphocyte antigen (HLA-B 3801) mRNA, complete cds.
L37880 - Homo sapiens MHC class I HLA-B*8101 gene exons 1-8, complete cds.
L37881 - Homo sapiens MHC class I HLA-B*1523 mRNA, complete cds.
L38504 - Homo sapiens (clones 18.1, 18.2, 19.2) MHC class I HLA-B*2702 mRNA, complete cds.
L41214 - Homo sapiens MHC class I HLA-B*7802 mRNA, complete cds.
L41925 - Homo sapiens MHC HLA-B*51022 mRNA, complete cds.
M77774 - Human HLA-B*5401 mRNA, complete cds.
M77775 - Human HLA-B*5602 mRNA, complete cds.
M77776 - Human HLA-B*5601 mRNA, complete cds.
M77777 - Human HLA-B*5502 mRNA, complete cds.
M77778 - Human HLA-B*5501 mRNA, complete cds.
M81798 - Human MHC class I protein (HLA-B) mRNA, complete cds.
M84694 - Human MHC class I HLA-B*4005 mRNA, complete cds.
U01848 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*1517 allele, complete cds.
U03027 - Human cell line GEE018 (HLA B-1519) mRNA, complete cds.
U03698 - Human HLA B-40011 mRNA, complete cds.
U03859 - Human MHC Class I HLA-B-1501 mRNA, complete cds.
U04243 - Human MHC class I antigen HLA-B (HLA-B-39022 allele) mRNA, complete cds.
U04244 - Human MHC class I antigen HLA-B (HLA-B-0802 allele) mRNA, complete cds.
U09864 - Human HLA-B-1521 mRNA, complete cds.
U09912 - Human MHC class I histocompatibility antigen HLA-B (HLA-B-4803 allele) mRNA, complete cds.
U17107 - Human isolate MAP9 MHC class I antigen (HLA-B35) mRNA, complete cds.
U21053 - Human MHC class I antigen heavy chain HLA-B (HLA-B-0703) mRNA, complete cds.
U27608 - Human MHC class I antigen HLA-B (HLA-B-2704 allele) mRNA, complete cds.
U29057 - Human MHC class I antigen HLA-B7 variant (HLA-B) mRNA, complete cds.
U29083 - Homo sapiens MHC class I antigen (HLA-B) mRNA, complete cds.
U29480 - Human MHC class I antigen (HLA-B39) mRNA, complete cds.
U30904 - Human (HLA-B) mRNA, B-3515 allele, complete cds.
U30936 - Human MHC class I antigen HLA-B35 (B-3502new allele) mRNA, complete cds.
U31971 - Human MHC class I antigen HLA-B precursor (HLA-B) mRNA, complete cds.
U35431 - Human MHC class I antigen HLA-B (HLA-B-1517 allele) mRNA, complete cds.
U35734 - Human MHC class I antigen HLA-B alpha chain (HLA-B-2706 allele) mRNA, complete cds.
U36492 - Human MHC class I antigen (HLA-B) allele HLA-B-8201 mRNA, complete cds.
U38800 - Human HLA class I antigen (HLA-B), B-5602*new allele, mRNA, complete cds.
U40498 - Human MHC class I HLA-B38 mRNA, complete cds.
U70528 - Human MHC class I HLA-B*1504 mRNA, complete cds.
U75533 - Homo sapiens HLA class I antigen HLA-B mRNA (HLA-B*1303new allele), complete cds.
U80945 - Human MHC class I antigen (HLA-B) mRNA, allele HLA-B*1522, complete cds.
X61706 - Human RNA for HLA-Bw50 antigen.
X61707 - Human RNA for HLA-Bw57.2 antigen.
X61708 - Human RNA for HLA-Bw78 antigen.
X64366 - H.sapiens HLA-B*4403 mRNA for leucocyte antigen (HLA) class I molecule.
X64454 - H.sapiens mRNA for HLA-BPOT.
X73578 - H. sapiens HLA-B*2706 mRNA.
X84725 - H.sapiens mRNA for HLA-B alpha chain.
X90390 - H.sapiens mRNA for HLA-B antigen alpha chain (B*8101).
X90391 - H.sapiens mRNA for HLA-B antigen alpha chain (B*4407).
Y08995 - Homo sapiens mRNA for HLA-B antigen alpha chain (B*5002).
Y09058 - H.sapiens mRNA for HLA-B antigen alpha chain (B*39GB).
Z15143 - H.sapiens mRNA for MHC class I HLA-B*5104.
AK313911 - Homo sapiens cDNA, FLJ94549, Homo sapiens major histocompatibility complex, class I, B (HLA-B),mRNA.
DQ336696 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*1301 allele, partial cds.
AY221104 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*270502 variant allele, partial cds.
X75953 - H.sapiens HLA-B mRNA.
AF022783 - Homo sapiens MHC class I histocompatibility antigen HLA-B mRNA, partial cds.
U11261 - Human HLA-B50 (B-5001) mRNA, partial cds.
U11263 - Human HLA-B49 (B-4901) mRNA, partial cds.
U11265 - Human HLA-B35 (B-3501) mRNA, partial cds.
U17572 - Human MHC class I HLA-B41 variant mRNA, partial cds.
D14343 - Homo sapiens HLA-B61 mRNA, partial cds.
Y09118 - H.sapiens mRNA for human leukocyte antigen B (HLA-B*47 variant).
AY569160 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*35 variant allele, partial cds.
U06697 - Human clone C21/14 MHC class I histocompatibility antigen (HLA-B) mRNA, partial cds.
DQ336697 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*4801 allele, partial cds.
AK301008 - Homo sapiens cDNA FLJ52207 complete cds, highly similar to HLA class I histocompatibility antigen, B-7 alpha chain precursor.
AK309345 - Homo sapiens cDNA, FLJ99386.
AK303541 - Homo sapiens cDNA FLJ53569 complete cds, moderately similar to HLA class I histocompatibility antigen, B-8 alpha chain precursor.
AK310586 - Homo sapiens cDNA, FLJ17628.
L42545 - Homo sapiens MHC class I (HLA-B) mRNA, HLA-B*35 allele, partial cds.
L47984 - Homo sapiens major histocompatibility complex class I (HLA-B) mRNA, HLA-B*52012 allele, partial cds.
L47985 - Homo sapiens major histocompatibility complex class I (HLA-B) mRNA, HLA-B*5101 allele, partial cds.
L48400 - Homo sapiens MHC class I (HLA-B) mRNA, HLA-B*1501 allele, partial cds.
L49343 - Homo sapiens lymphocyte antigen (HLA-B) mRNA, HLA-B*1515 allele, partial cds.
L76934 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B-B*4002 allele, partial cds.
L76935 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*2701 allele, partial cds.
L79935 - Homo sapiens (individual isolate ARG50) MHC class I mRNA, exons 2 and 3 (HLA-B*3801).
L79936 - Homo sapiens (individual isolate N263) MHC class I mRNA, exons 2 and 3 (HLA-B*3802).
U18790 - Human MHC class I HLA-B mRNA (HLA-B-57SAU allele) exons 2 and 3, partial cds.
U34619 - Human MHC class I antigen HLA-B35 IEF variant (HLA-B) mRNA, G2997 lymphocytes, partial cds.
U39088 - Homo sapiens MHC class I antigen B*5703 (HLA-B) mRNA, partial cds.
AF436094 - Homo sapiens MHC class I antigen (HLA-B) mRNA, HLA-B*3512 allele, partial cds.
U96942 - Homo sapiens MHC class I HLA-B (HLA-B*4002 allele variant) mRNA, partial cds.
Z46808 - H.sapiens HLA-B*5101 mRNA for HLA-B51.
L79937 - Homo sapiens (individual isolate 17710) MHC class I mRNA, exons 2 and 3 (HLA-B40012).
AF081275 - Homo sapiens MHC class I antigen HLA-B mRNA (HLA-B39 variant allele), partial cds.
E01342 - cDNA encoding C-terminal Fragment of HLA-B27.
AM261441 - Homo sapiens mRNA for MHC class I antigen (HLA-B gene), HLA-B*3565Q allele.
GQ141863 - Homo sapiens MHC class I antigen (HLA-B) gene, HLA-B*13 new allele, complete cds.
HE663398 - Homo sapiens partial mRNA for MHC class I antigen (HLA-B gene), allele HLA-B*35 variant.
HG327115 - Homo sapiens mRNA for MHC class I antigen (HLA-B gene), isolate 4388, allele HLA-B*27:17.
HG327119 - Homo sapiens mRNA for MHC class I antigen (HLA-B gene), isolate 20193, allele HLA-B*56:07.
HG327120 - Homo sapiens mRNA for MHC class I antigen (HLA-B gene), isolate 21871, allele HLA-B*35:42:01.
HG327121 - Homo sapiens mRNA for MHC class I antigen (HLA-B gene), isolate 23293, allele HLA-B*14:06:01.
HG327122 - Homo sapiens mRNA for MHC class I antigen (HLA-B gene), isolate 34873, allele HLA-B*27:10.
EU668336 - Homo sapiens epididymis secretory protein Li 83 (HEL-S-83) mRNA, complete cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04144 - Endocytosis
hsa04514 - Cell adhesion molecules (CAMs)
hsa04612 - Antigen processing and presentation
hsa04650 - Natural killer cell mediated cytotoxicity
hsa04940 - Type I diabetes mellitus
hsa05320 - Autoimmune thyroid disease
hsa05330 - Allograft rejection
hsa05332 - Graft-versus-host disease
hsa05416 - Viral myocarditis

-  Other Names for This Gene
  Alternate Gene Symbols: Q30194, Q30194_HUMAN, X86703
UCSC ID: uc011gww.1
RefSeq Accession: NM_002117
Protein: Q30194

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: X86703.1
exon count: 2CDS single in 3' UTR: no RNA size: 546
ORF size: 513CDS single in intron: no Alignment % ID: 96.58
txCdsPredict score: 987.50frame shift in genome: no % Coverage: 96.34
has start codon: yes stop codon in genome: no # of Alignments: 2
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.