Human Gene POU5F1 (uc011gwl.2) Description and Page Index
  Description: Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 1, mRNA.
RefSeq Summary (NM_002701): This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,480,458-2,486,814 Size: 6,357 Total Exon Count: 5 Strand: -
Coding Region
   Position: chr6_mann_hap4:2,480,722-2,486,760 Size: 6,039 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: POU5F1
CDC HuGE Published Literature: POU5F1
Positive Disease Associations: Behcet Syndrome , Multiple Sclerosis , Stevens-Johnson Syndrome
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  3. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
           more ... click here to view the complete list

+  Comparative Toxicogenomics Database (CTD)
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-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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+  mRNA Secondary Structure of 3' and 5' UTRs
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+  Protein Domain and Structure Information
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Jackson Lab     
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  AM851115 - Homo sapiens partial mRNA for POU domain class 5 transcription factor 1 (POU5F1 gene), clone 1.
DQ486517 - Homo sapiens POU domain transcription factor Oct-3 alternative transcript 6.4 (POU5F1) pseudogene mRNA, complete sequence, alternatively spliced.
Z11899 - H.sapiens OTF3 mRNA encoding octamer binding protein 3B.
BC020712 - Homo sapiens POU domain, class 5, transcription factor 1, mRNA (cDNA clone IMAGE:4717277).
DQ486515 - Homo sapiens POU domain transcription factor Oct-3 alternative transcript 6.2 (POU5F1) pseudogene mRNA, complete sequence, alternatively spliced.
DQ486516 - Homo sapiens POU domain transcription factor Oct-3 alternative transcript 6.3 (POU5F1) pseudogene mRNA, complete sequence, alternatively spliced.
DQ486514 - Homo sapiens POU domain transcription factor Oct-3 alternative transcript 6.1 (POU5F1) pseudogene mRNA, complete sequence, alternatively spliced.
BC069246 - Homo sapiens POU class 5 homeobox 1, mRNA (cDNA clone IMAGE:6578897), with apparent retained intron.
Z11898 - H.sapiens OTF3 mRNA encoding octamer binding protein 3A.
BC117435 - Homo sapiens POU class 5 homeobox 1, mRNA (cDNA clone MGC:151044 IMAGE:40125986), complete cds.
BC117437 - Homo sapiens POU class 5 homeobox 1, mRNA (cDNA clone MGC:151046 IMAGE:40125988), complete cds.
GU480808 - Homo sapiens isolate NT2-1 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480809 - Homo sapiens isolate NT2-2 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480810 - Homo sapiens isolate NT2-3 POU domain transcription factor OCT4 (POU5F1)-like mRNA, complete sequence.
GU480811 - Homo sapiens isolate NT2-4 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480812 - Homo sapiens isolate NT2-5 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480813 - Homo sapiens isolate NT2-6 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480815 - Homo sapiens isolate NT2-8 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480816 - Homo sapiens isolate NT2-9 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480817 - Homo sapiens isolate NT2-10 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480818 - Homo sapiens isolate NT2-11 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480819 - Homo sapiens isolate NT2-12 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480820 - Homo sapiens isolate NT2-13 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480821 - Homo sapiens isolate NT2-14 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480822 - Homo sapiens isolate NT2-15 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480823 - Homo sapiens isolate NT2-16 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480824 - Homo sapiens isolate NT2-17 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480825 - Homo sapiens isolate NT2-18 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480826 - Homo sapiens isolate NT2-19 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480827 - Homo sapiens isolate NT2-20 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480828 - Homo sapiens isolate NT2-21 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480829 - Homo sapiens isolate NT2-22 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480830 - Homo sapiens isolate NT2-23 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
GU480844 - Homo sapiens clone U251-14 POU domain transcription factor OCT4-pg1 (POU5F1P1) pseudogene mRNA, complete sequence.
GU480856 - Homo sapiens clone MCF7-3 POU domain transcription factor OCT4-pg4 (POU5F1P4) pseudogene mRNA, complete sequence.
GU480886 - Homo sapiens clone Glioma-12 POU domain transcription factor OCT4-pg1 (POU5F1P1) mRNA, complete cds.
GU480888 - Homo sapiens clone Glioma-14 POU domain transcription factor OCT4-pg3 (POU5F1P3) pseudogene mRNA, complete sequence.
GU480891 - Homo sapiens clone Glioma-17 POU domain transcription factor OCT4-pg3 (POU5F1P3) pseudogene mRNA, complete sequence.
GU480897 - Homo sapiens clone B-2 POU domain transcription factor OCT4-pg3 (POU5F1P3) mRNA, complete cds.
GU480915 - Homo sapiens clone B-20 POU domain transcription factor OCT4-pg3 (POU5F1P3) mRNA, complete cds.
HQ122658 - Homo sapiens clone S-1 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
HQ122659 - Homo sapiens clone S-2 POU domain transcription factor OCT4-like (POU5F1) mRNA, complete sequence.
HQ122660 - Homo sapiens clone S-3 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
HQ122661 - Homo sapiens clone S-4 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
HQ122662 - Homo sapiens clone S-5 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
HQ122663 - Homo sapiens clone S-6 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
HQ122664 - Homo sapiens clone S-7 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
HQ122665 - Homo sapiens clone S-8 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
HQ122666 - Homo sapiens clone S-9 POU domain transcription factor OCT4-like (POU5F1) mRNA, complete sequence.
HQ122667 - Homo sapiens clone S-10 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
HQ122668 - Homo sapiens clone S-11 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
HQ122669 - Homo sapiens clone S-12 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
HQ122670 - Homo sapiens clone S-13 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
HQ122671 - Homo sapiens clone S-14 POU domain transcription factor OCT4-like (POU5F1) mRNA, complete sequence.
HQ122672 - Homo sapiens clone S-15 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
HQ122673 - Homo sapiens clone S-16 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
HQ122674 - Homo sapiens clone S-17 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
HQ122675 - Homo sapiens clone S-18 POU domain transcription factor OCT4 (POU5F1) mRNA, complete cds.
HQ122860 - Homo sapiens clone LB-12 POU domain transcription factor OCT4-pg4 (POU5F1P4) mRNA, complete cds.
HQ122904 - Homo sapiens clone Basal-1 POU domain transcription factor OCT4-pg4 (POU5F1P4) pseudogene mRNA, complete sequence.
HQ258221 - Synthetic construct Homo sapiens clone IMAGE:100072530 POU class 5 homeobox 1 (POU5F1) gene, encodes complete protein.
HQ258573 - Synthetic construct Homo sapiens clone IMAGE:100073096 POU class 5 homeobox 1 (POU5F1) gene, encodes complete protein.
AB528279 - Synthetic construct DNA, clone: pF1KB7614, Homo sapiens OCT4 gene for POU class 5 homeobox 1, without stop codon, in Flexi system.
S81255 - OCT4=transcriptional regulator [human, tripronuclear ova and embryos, mRNA Partial, 225 nt].
AY730056 - Homo sapiens POU domain class 5 transcription factor 1-like (POU5F1) mRNA, partial sequence.
EU518650 - Homo sapiens POU domain transcription factor Oct4 isoform 3 (POU5F1) mRNA, complete cds, alternatively spliced.
FM177952 - Homo sapiens partial mRNA for POU class 5 homeobox 1 (POU5F1 gene), clone ARO0003059.
FM177953 - Homo sapiens partial mRNA for POU class 5 homeobox 1 (POU5F1 gene), clone ARO0003060.
FM177954 - Homo sapiens partial mRNA for POU class 5 homeobox 1 (POU5F1 gene), clone EC-1.
FM177955 - Homo sapiens partial mRNA for POU class 5 homeobox 1 (POU5F1 gene), clone EC-2.
FM177956 - Homo sapiens partial mRNA for POU class 5 homeobox 1 (POU5F1 gene), clone EC-TAKA-01.
FM177959 - Homo sapiens partial mRNA for POU class 5 homeobox 1 (POU5F1 gene), clone EC-TAKA-04.
FM177960 - Homo sapiens partial mRNA for POU class 5 homeobox 1 (POU5F1 gene), clone EC-TAKA-05.
FM177961 - Homo sapiens partial mRNA for POU class 5 homeobox 1 (POU5F1 gene), clone EC-TAKA-06.
FM177962 - Homo sapiens partial mRNA for POU class 5 homeobox 1 (POU5F1 gene), clone EC-TAKA-08.
FM177963 - Homo sapiens partial mRNA for POU class 5 homeobox 1 (POU5F1 gene), clone EC-TAKA-09.
FM177965 - Homo sapiens partial mRNA for POU class 5 homeobox 1 (POU5F1 gene), clone BM1819.
FM177968 - Homo sapiens partial mRNA for POU class 5 homeobox 1 (POU5F1 gene), clone UVSC-TAKA-01.
AM851123 - Homo sapiens partial mRNA for POU domain class 5 transcription factor 1 (POU5F1 gene), clone 9.
AM851121 - Homo sapiens partial mRNA for POU domain class 5 transcription factor 1 (POU5F1 gene), clone 7.
AM851116 - Homo sapiens partial mRNA for POU domain class 5 transcription factor 1 (POU5F1 gene), clone 2.
AM851118 - Homo sapiens partial mRNA for POU domain class 5 transcription factor 1 (POU5F1 gene), clone 4.
AM851125 - Homo sapiens partial mRNA for POU domain class 5 transcription factor 1 (POU5F1 gene), clone 11.
AM851119 - Homo sapiens mRNA for putative truncated POU domain class 5 transcription factor 1 (POU5F1 gene), clone 5.
AM851120 - Homo sapiens partial mRNA for POU domain class 5 transcription factor 1 (POU5F1 gene), clone 6.
AM851117 - Homo sapiens mRNA for putative truncated POU domain class 5 transcription factor 1 (POU5F1 gene), clone 3.
AM851126 - Homo sapiens partial mRNA for POU domain class 5 transcription factor 1 (POU5F1 gene), clone 12.
AM851124 - Homo sapiens partial mRNA for POU domain class 5 transcription factor 1 (POU5F1 gene), clone 10.
AM851122 - Homo sapiens partial mRNA for POU domain class 5 transcription factor 1 (POU5F1 gene), clone 8.
HW243465 - JP 2013512690-A/16: RNA PREPARATIONS COMPRISING PURIFIED MODIFIED RNA FOR REPROGRAMMING CELLS.

+  Other Names for This Gene
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-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_002701.4
exon count: 5CDS single in 3' UTR: no RNA size: 1411
ORF size: 1083CDS single in intron: no Alignment % ID: 99.71
txCdsPredict score: 2366.00frame shift in genome: no % Coverage: 99.29
has start codon: yes stop codon in genome: no # of Alignments: 7
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
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