Human Gene TCF19 (uc011gwi.2) Description and Page Index
  Description: Homo sapiens transcription factor 19 (TCF19), transcript variant 1, mRNA.
RefSeq Summary (NM_007109): This gene encodes a protein that belongs to the Plant Homeo Domain finger family of transcription factors. The encoded protein is thought to function during the G1/S transition in the cell cycle. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,474,681-2,480,336 Size: 5,656 Total Exon Count: 4 Strand: +
Coding Region
   Position: chr6_mann_hap4:2,475,625-2,478,837 Size: 3,213 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Comments and Description Text from UniProtKB
  ID: TCF19_HUMAN
DESCRIPTION: RecName: Full=Transcription factor 19; Short=TCF-19; AltName: Full=Transcription factor SC1;
FUNCTION: Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.
SUBCELLULAR LOCATION: Nucleus (Potential).
DEVELOPMENTAL STAGE: Growth regulated.
SIMILARITY: Contains 1 FHA domain.
SIMILARITY: Contains 1 PHD-type zinc finger.
SEQUENCE CAUTION: Sequence=AAB60363.1; Type=Frameshift; Positions=288, 290, 291; Sequence=AAB60363.1; Type=Frameshift; Positions=288;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: TCF19
CDC HuGE Published Literature: TCF19
Positive Disease Associations: Behcet Syndrome , Lupus Erythematosus, Systemic , Multiple Sclerosis , Psoriasis
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Lupus Erythematosus, Systemic
    , , . [PubMed 0]
  3. Lupus Erythematosus, Systemic
    Geoffrey Hom et al. The New England journal of medicine 2008, Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX., The New England journal of medicine. [PubMed 18204098]
    We identified and then confirmed through replication two new genetic loci for SLE: a promoter-region allele associated with reduced expression of BLK and increased expression of C8orf13 and variants in the ITGAM-ITGAX region.
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D004052 Diethylnitrosamine
  • C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene
  • D015655 1-Methyl-4-phenylpyridinium
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
  • C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D000082 Acetaminophen
          more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -303.10770-0.394 Picture PostScript Text
3' UTR -469.651499-0.313 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000253 - FHA_dom
IPR008984 - SMAD_FHA_domain
IPR019786 - Zinc_finger_PHD-type_CS
IPR011011 - Znf_FYVE_PHD
IPR001965 - Znf_PHD
IPR019787 - Znf_PHD-finger
IPR013083 - Znf_RING/FYVE/PHD

Pfam Domains:
PF00498 - FHA domain
PF00628 - PHD-finger

SCOP Domains:
49879 - SMAD/FHA domain
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on Q9Y242
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Jackson Lab     
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  AK056834 - Homo sapiens cDNA FLJ32272 fis, clone PROST1000564.
BX647174 - Homo sapiens mRNA; cDNA DKFZp686N23239 (from clone DKFZp686N23239).
BC044632 - Homo sapiens transcription factor 19, mRNA (cDNA clone MGC:52412 IMAGE:4841638), complete cds.
AK315258 - Homo sapiens cDNA, FLJ96263.
BC033086 - Homo sapiens transcription factor 19, mRNA (cDNA clone MGC:45652 IMAGE:3160434), complete cds.
S53374 - SC1=putative trans-acting factor involved in cell cycle control [human, mRNA, 2481 nt].
BC002493 - Homo sapiens transcription factor 19, mRNA (cDNA clone MGC:2575 IMAGE:3051226), complete cds.
AB527740 - Synthetic construct DNA, clone: pF1KB7916, Homo sapiens TCF19 gene for transcription factor 19, without stop codon, in Flexi system.
DQ895842 - Synthetic construct Homo sapiens clone IMAGE:100010302; FLH188203.01L; RZPDo839H08149D transcription factor 19 (SC1) (TCF19) gene, encodes complete protein.
EU176376 - Synthetic construct Homo sapiens clone IMAGE:100006582; FLH263905.01X; RZPDo839F02246D transcription factor 19 (SC1) (TCF19) gene, encodes complete protein.
CU677998 - Synthetic construct Homo sapiens gateway clone IMAGE:100019036 5' read TCF19 mRNA.
BT007247 - Homo sapiens transcription factor 19 (SC1) mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NCT8, B0UY11, NM_007109, NP_009040, Q0EFA8, Q13176, Q15967, Q5SQ89, Q5STD6, Q5STF5, Q9BUM2, Q9UBH7, Q9Y242, SC1, TCF19_HUMAN
UCSC ID: uc011gwi.2
RefSeq Accession: NM_007109
Protein: Q9Y242 (aka TCF19_HUMAN