Human Gene TCF19 (uc011gwi.2) Description and Page Index
Description: Homo sapiens transcription factor 19 (TCF19), transcript variant 1, mRNA. RefSeq Summary (NM_007109): This gene encodes a protein that belongs to the Plant Homeo Domain finger family of transcription factors. The encoded protein is thought to function during the G1/S transition in the cell cycle. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]. Transcript (Including UTRs) Position: chr6_mann_hap4:2,474,681-2,480,336 Size: 5,656 Total Exon Count: 4 Strand: + Coding Region Position: chr6_mann_hap4:2,475,625-2,478,837 Size: 3,213 Coding Exon Count: 3
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Comments and Description Text from UniProtKB
ID:TCF19_HUMAN DESCRIPTION: RecName: Full=Transcription factor 19; Short=TCF-19; AltName: Full=Transcription factor SC1; FUNCTION: Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression. SUBCELLULAR LOCATION: Nucleus (Potential). DEVELOPMENTAL STAGE: Growth regulated. SIMILARITY: Contains 1 FHA domain. SIMILARITY: Contains 1 PHD-type zinc finger. SEQUENCE CAUTION: Sequence=AAB60363.1; Type=Frameshift; Positions=288, 290, 291; Sequence=AAB60363.1; Type=Frameshift; Positions=288;
Genetic Association Studies of Complex Diseases and Disorders
Lupus Erythematosus, Systemic Geoffrey Hom et al. The New England journal of medicine 2008, Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX., The New England journal of medicine.
We identified and then confirmed through replication two new genetic loci for SLE: a promoter-region allele associated with reduced expression of BLK and increased expression of C8orf13 and variants in the ITGAM-ITGAX region.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y242
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.