Human Gene TCF19 (uc011gwi.2) Description and Page Index
  Description: Homo sapiens transcription factor 19 (TCF19), transcript variant 1, mRNA.
RefSeq Summary (NM_007109): This gene encodes a protein that belongs to the Plant Homeo Domain finger family of transcription factors. The encoded protein is thought to function during the G1/S transition in the cell cycle. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,474,681-2,480,336 Size: 5,656 Total Exon Count: 4 Strand: +
Coding Region
   Position: chr6_mann_hap4:2,475,625-2,478,837 Size: 3,213 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: TCF19
CDC HuGE Published Literature: TCF19
Positive Disease Associations: Behcet Syndrome , Lupus Erythematosus, Systemic , Multiple Sclerosis , Psoriasis
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Lupus Erythematosus, Systemic
    , , . [PubMed 0]
  3. Lupus Erythematosus, Systemic
    Geoffrey Hom et al. The New England journal of medicine 2008, Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX., The New England journal of medicine. [PubMed 18204098]
    We identified and then confirmed through replication two new genetic loci for SLE: a promoter-region allele associated with reduced expression of BLK and increased expression of C8orf13 and variants in the ITGAM-ITGAX region.
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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D004052 Diethylnitrosamine
  • C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene
  • D015655 1-Methyl-4-phenylpyridinium
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
  • C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D000082 Acetaminophen
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-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -303.10770-0.394 Picture PostScript Text
3' UTR -469.651499-0.313 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

+  Protein Domain and Structure Information
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+  Orthologous Genes in Other Species
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-  Descriptions from all associated GenBank mRNAs
  AK056834 - Homo sapiens cDNA FLJ32272 fis, clone PROST1000564.
BX647174 - Homo sapiens mRNA; cDNA DKFZp686N23239 (from clone DKFZp686N23239).
BC044632 - Homo sapiens transcription factor 19, mRNA (cDNA clone MGC:52412 IMAGE:4841638), complete cds.
AK315258 - Homo sapiens cDNA, FLJ96263.
BC033086 - Homo sapiens transcription factor 19, mRNA (cDNA clone MGC:45652 IMAGE:3160434), complete cds.
S53374 - SC1=putative trans-acting factor involved in cell cycle control [human, mRNA, 2481 nt].
BC002493 - Homo sapiens transcription factor 19, mRNA (cDNA clone MGC:2575 IMAGE:3051226), complete cds.
AB527740 - Synthetic construct DNA, clone: pF1KB7916, Homo sapiens TCF19 gene for transcription factor 19, without stop codon, in Flexi system.
DQ895842 - Synthetic construct Homo sapiens clone IMAGE:100010302; FLH188203.01L; RZPDo839H08149D transcription factor 19 (SC1) (TCF19) gene, encodes complete protein.
EU176376 - Synthetic construct Homo sapiens clone IMAGE:100006582; FLH263905.01X; RZPDo839F02246D transcription factor 19 (SC1) (TCF19) gene, encodes complete protein.
CU677998 - Synthetic construct Homo sapiens gateway clone IMAGE:100019036 5' read TCF19 mRNA.
BT007247 - Homo sapiens transcription factor 19 (SC1) mRNA, complete cds.

+  Other Names for This Gene
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+  Gene Model Information
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+  Methods, Credits, and Use Restrictions
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