Human Gene PSORS1C2 (uc011gwb.2) Description and Page Index
  Description: Homo sapiens psoriasis susceptibility 1 candidate 2 (PSORS1C2), mRNA.
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,453,679-2,455,495 Size: 1,817 Total Exon Count: 2 Strand: -
Coding Region
   Position: chr6_mann_hap4:2,454,096-2,455,171 Size: 1,076 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Psoriasis susceptibility 1 candidate gene 2 protein; AltName: Full=Protein SPR1; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Potential).
TISSUE SPECIFICITY: Expressed in skin. Also expressed in heart and skeletal muscle.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: PSORS1C2
CDC HuGE Published Literature: PSORS1C2
Positive Disease Associations: Behcet Syndrome , Psoriasis , Sclerosis
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  3. Psoriasis
    , , . [PubMed 0]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips


-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -130.78324-0.404 Picture PostScript Text
3' UTR -99.53417-0.239 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q9UIG4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Jackson Lab     
Protein Sequence     

-  Descriptions from all associated GenBank mRNAs
  BC113974 - Homo sapiens cDNA clone IMAGE:40010559.
AB031480 - Homo sapiens SPR1 mRNA, complete cds.
AF484420 - Homo sapiens psoriasis susceptibility 1 candidate 2 (PSORS1C2) mRNA, complete cds.
BC107035 - Homo sapiens psoriasis susceptibility 1 candidate 2, mRNA (cDNA clone IMAGE:40000214).
BC172314 - Synthetic construct Homo sapiens clone IMAGE:100069008, MGC:199019 psoriasis susceptibility 1 candidate 2 (PSORS1C2) mRNA, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: C6orf17, NM_014069, NP_054788, PS1C2_HUMAN, Q5STD0, Q9UIG4, SPR1
UCSC ID: uc011gwb.2
RefSeq Accession: NM_014069
Protein: Q9UIG4 (aka PS1C2_HUMAN