Human Gene CDSN (uc011gvz.2) Description and Page Index
  Description: Homo sapiens corneodesmosin (CDSN), mRNA.
RefSeq Summary (NM_001264): This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. During maturation of the cornified layers, the protein undergoes a series of cleavages, which are thought to be required for desquamation. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L20815.1, AK292636.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025090, ERS025098 [ECO:0000348] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,431,222-2,436,605 Size: 5,384 Total Exon Count: 2 Strand: -
Coding Region
   Position: chr6_mann_hap4:2,432,156-2,436,549 Size: 4,394 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: CDSN
CDC HuGE Published Literature: CDSN
Positive Disease Associations: Behcet Syndrome , Body Composition , HIV-1 control , Leukocyte Count , Multiple Sclerosis , psoriasis
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Body Composition
    , , . [PubMed 0]
  3. HIV-1 control
    Fellay ,et al. 2009, Common Genetic Variation and the Control of HIV-1 in Human, PLoS genetics 2009 5- 12 : e1000791. [PubMed 20041166]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.9056-0.302 Picture PostScript Text
3' UTR -269.73934-0.289 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

+  Protein Domain and Structure Information
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+  Orthologous Genes in Other Species
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-  Descriptions from all associated GenBank mRNAs
  L20815 - Human S protein mRNA, complete cds.
BC031993 - Homo sapiens corneodesmosin, mRNA (cDNA clone MGC:21340 IMAGE:4747362), complete cds.
AK292636 - Homo sapiens cDNA FLJ78714 complete cds, highly similar to Homo sapiens corneodesmosin, mRNA.
AF030130 - Homo sapiens corneodesmosin mRNA, complete cds.
DQ891583 - Synthetic construct clone IMAGE:100004213; FLH178352.01X; RZPDo839C03128D corneodesmosin (CDSN) gene, encodes complete protein.
DQ894777 - Synthetic construct Homo sapiens clone IMAGE:100009237; FLH178348.01L; RZPDo839C03127D corneodesmosin (CDSN) gene, encodes complete protein.
CU689256 - Synthetic construct Homo sapiens gateway clone IMAGE:100019780 5' read CDSN mRNA.

+  Other Names for This Gene
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+  Gene Model Information
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+  Methods, Credits, and Use Restrictions
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