Human Gene MUC21 (uc011gvs.1) Description and Page Index
  Description: Homo sapiens mucin 21, cell surface associated (MUC21), mRNA.
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,299,571-2,305,856 Size: 6,286 Total Exon Count: 3 Strand: +
Coding Region
   Position: chr6_mann_hap4:2,299,828-2,304,152 Size: 4,325 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Comments and Description Text from UniProtKB
  ID: MUC21_HUMAN
DESCRIPTION: RecName: Full=Mucin-21; Short=MUC-21; AltName: Full=Epiglycanin; Flags: Precursor;
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein; Extracellular side.
TISSUE SPECIFICITY: Expressed in lung, large intestine, thymus, and testis. Expressed in normal and malignant bronchial epithelial cells.
PTM: O-glycosylated.
MISCELLANEOUS: Could be considered as a marker for lung carcinomas.
SEQUENCE CAUTION: Sequence=AAI05737.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
WEB RESOURCE: Name=Mucin database; URL="http://www.medkem.gu.se/mucinbiology/databases/";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: MUC21
CDC HuGE Published Literature: MUC21
Positive Disease Associations: Behcet Syndrome , Graves Disease , Hypothyroidism , Lupus Erythematosus, Systemic , Psoriasis , Stevens-Johnson Syndrome , Triglycerides
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  3. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -69.06257-0.269 Picture PostScript Text
3' UTR -590.151704-0.346 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR028199 - Mucin_dom
IPR008519 - Tandem-repeating_mucin

ModBase Predicted Comparative 3D Structure on Q5SSG8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Jackson Lab     
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  AK299471 - Homo sapiens cDNA FLJ50027 complete cds, weakly similar to Dentin sialophosphoprotein precursor.
AK316363 - Homo sapiens cDNA, FLJ79262 complete cds, weakly similar to Dentin sialophosphoprotein precursor.
AK298642 - Homo sapiens cDNA FLJ56824 complete cds, weakly similar to Dentin sialophosphoprotein precursor.
AY358415 - Homo sapiens clone DNA66674 KMQK697 (UNQ697) mRNA, complete cds.
BC105735 - Homo sapiens mucin 21, cell surface associated, mRNA (cDNA clone MGC:125612 IMAGE:40026480), complete cds.
BC105736 - Homo sapiens mucin 21, cell surface associated, mRNA (cDNA clone IMAGE:40026479), complete cds.
BC105737 - Homo sapiens mucin 21, cell surface associated, mRNA (cDNA clone MGC:125610 IMAGE:40026476), complete cds.
BC107478 - Homo sapiens mucin 21, cell surface associated, mRNA (cDNA clone MGC:125609 IMAGE:40026469), complete cds.
HM596784 - Homo sapiens epiglycanin (MUC21) mRNA, complete cds.
AB242595 - Homo sapiens MUC21 mRNA for mucin 21, complete cds.
AK301645 - Homo sapiens cDNA FLJ54412 complete cds, moderately similar to Homo sapiens dentin sialophosphoprotein (DSPP), mRNA.
AK056612 - Homo sapiens cDNA FLJ32050 fis, clone NTONG2001222.

-  Other Names for This Gene
  Alternate Gene Symbols: B0UZT7, B4DQ55, C6orf205, C9JMK2, D9N007, MUC21_HUMAN, NM_001010909, Q0VGF1, Q3B7T2, Q5SS94, Q5SSG8, Q6UXC5, UNQ697/PRO1342
UCSC ID: uc011gvs.1
RefSeq Accession: NM_001010909
Protein: Q5SSG8 (aka MUC21_HUMAN