Human Gene VARS2 (uc011gvm.2) Description and Page Index
  Description: Homo sapiens valyl-tRNA synthetase 2, mitochondrial (VARS2), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,230,666-2,242,316 Size: 11,651 Total Exon Count: 28 Strand: +


Page IndexSequence and LinksGenetic AssociationsCTDMicroarrayOther Species
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: VARS2
CDC HuGE Published Literature: VARS2
Positive Disease Associations: Behcet Syndrome , Leprosy , Lupus Erythematosus, Systemic , Sodium
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  3. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
Ratios
      
      
      
     
    
     
Absolute
      
       
      
      
     
    
Ratios
      
       
      
      
     
    
Absolute
   
     
     
Ratios
   
     
     
Absolute

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AB209479 - Homo sapiens premature mRNA for VARS2L protein variant.
AB067472 - Homo sapiens mRNA for KIAA1885 protein, partial cds.
AK303415 - Homo sapiens cDNA FLJ56191 complete cds, highly similar to Homo sapiens valyl-tRNA synthetase like (VARSL), mRNA.
AK293780 - Homo sapiens cDNA FLJ59483 complete cds, highly similar to Homo sapiens valyl-tRNA synthetase like (VARSL), mRNA.
AK294451 - Homo sapiens cDNA FLJ53779 complete cds, highly similar to Homo sapiens valyl-tRNA synthetase like (VARSL), mRNA.
AK000511 - Homo sapiens cDNA FLJ20504 fis, clone KAT09455, highly similar to SYV_FUGRU VALYL-TRNA SYNTHETASE.
AK304807 - Homo sapiens cDNA FLJ55611 complete cds, highly similar to Homo sapiens valyl-tRNA synthetase like (VARSL), mRNA.
BC143535 - Homo sapiens cDNA clone IMAGE:9052044.
BC113605 - Homo sapiens valyl-tRNA synthetase 2, mitochondrial (putative), mRNA (cDNA clone MGC:142165 IMAGE:8322657), complete cds.
BC112054 - Homo sapiens valyl-tRNA synthetase 2, mitochondrial (putative), mRNA (cDNA clone MGC:138259 IMAGE:8327522), complete cds.
BC143534 - Homo sapiens cDNA clone IMAGE:9052043.
BC143536 - Homo sapiens valyl-tRNA synthetase 2, mitochondrial (putative), mRNA (cDNA clone MGC:177062 IMAGE:9052045), complete cds.
AB384648 - Synthetic construct DNA, clone: pF1KA1885, Homo sapiens KIAA1885 gene for valyl-tRNA synthetase 2-like protein, complete cds, without stop codon, in Flexi system.
AK125069 - Homo sapiens cDNA FLJ43079 fis, clone BRTHA3016917.
BC009355 - Homo sapiens valyl-tRNA synthetase 2, mitochondrial (putative), mRNA (cDNA clone IMAGE:4298611), partial cds.
AK315733 - Homo sapiens cDNA, FLJ96840, highly similar to Homo sapiens valyl-tRNA synthetase 2-like (VARS2L), mRNA.
BC063427 - Homo sapiens valyl-tRNA synthetase like, mRNA (cDNA clone IMAGE:5241568).
BC073838 - Homo sapiens valyl-tRNA synthetase 2, mitochondrial (putative), mRNA (cDNA clone IMAGE:4938443), partial cds.
AK025618 - Homo sapiens cDNA: FLJ21965 fis, clone HEP05617.
CU679315 - Synthetic construct Homo sapiens gateway clone IMAGE:100018380 5' read VARS2 mRNA.
BC008844 - Homo sapiens valyl-tRNA synthetase 2, mitochondrial (putative), mRNA (cDNA clone IMAGE:4299851), partial cds.
AK026063 - Homo sapiens cDNA: FLJ22410 fis, clone HRC08422.
AL122037 - Homo sapiens mRNA; cDNA DKFZp434L1435 (from clone DKFZp434L1435); partial cds.
AK094483 - Homo sapiens cDNA FLJ37164 fis, clone BRACE2027221, weakly similar to VALYL-TRNA SYNTHETASE (EC 6.1.1.9).

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00290 - Valine, leucine and isoleucine biosynthesis
hsa00970 - Aminoacyl-tRNA biosynthesis

-  Other Names for This Gene
  Alternate Gene Symbols: BC143535
UCSC ID: uc011gvm.2
RefSeq Accession: NM_020442

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: BC143535.1
exon count: 28CDS single in 3' UTR: no RNA size: 3183
ORF size: 0CDS single in intron: no Alignment % ID: 99.69
txCdsPredict score: 5278.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 6
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.