Human Gene DDR1 (uc011gux.1) Description and Page Index
  Description: Homo sapiens discoidin domain receptor tyrosine kinase 1 (DDR1), transcript variant 3, mRNA.
RefSeq Summary (NM_001202522): Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,207,242-2,214,165 Size: 6,924 Total Exon Count: 11 Strand: +
Coding Region
   Position: chr6_mann_hap4:2,207,280-2,214,165 Size: 6,886 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Comments and Description Text from UniProtKB
  ID: A2ABM8_HUMAN
DESCRIPTION: SubName: Full=Epithelial discoidin domain-containing receptor 1; Flags: Fragment;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: DDR1
CDC HuGE Published Literature: DDR1
Positive Disease Associations: Behcet Syndrome , Psoriasis , schizophrenia
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Psoriasis
    , , . [PubMed 0]
  3. Psoriasis
    , , . [PubMed 0]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -12.5038-0.329 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_dom
IPR001245 - Ser-Thr/Tyr_kinase_cat_dom

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on A2ABM8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  AK291621 - Homo sapiens cDNA FLJ75091 complete cds, highly similar to Homo sapiens discoidin domain receptor family, member 1 (DDR1),transcript variant 2, mRNA.
BC008716 - Homo sapiens discoidin domain receptor tyrosine kinase 1, mRNA (cDNA clone MGC:8681 IMAGE:2964574), complete cds.
BC013400 - Homo sapiens discoidin domain receptor tyrosine kinase 1, mRNA (cDNA clone MGC:3909 IMAGE:2964574), complete cds.
L20817 - Homo sapiens tyrosine protein kinase (CAK) gene, complete cds.
L57508 - Homo sapiens Cak receptor kinase mRNA, complete cds.
BC070070 - Homo sapiens discoidin domain receptor tyrosine kinase 1, mRNA (cDNA clone MGC:87336 IMAGE:5262509), complete cds.
AB210021 - Homo sapiens mRNA for DDR1 variant protein, partial cds, clone: fk11093.
L11315 - Homo sapiens receptor tyrosine kinase mRNA, complete cds.
AK294793 - Homo sapiens cDNA FLJ56035 complete cds, highly similar to Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1).
Z29093 - H.sapiens EDDR1 gene for receptor tyrosine kinase.
X74979 - H.sapiens TRK E mRNA.
EU826614 - Homo sapiens soluble DDR1 variant 2 (DDR1) mRNA, complete cds, alternatively spliced.
EU826613 - Homo sapiens soluble DDR1 variant 1 (DDR1) mRNA, complete cds, alternatively spliced.
CU687028 - Synthetic construct Homo sapiens gateway clone IMAGE:100022861 5' read DDR1 mRNA.
AB463012 - Synthetic construct DNA, clone: pF1KB2260, Homo sapiens DDR1 gene for discoidin domain receptor tyrosine kinase 1, without stop codon, in Flexi system.
AK130776 - Homo sapiens cDNA FLJ27266 fis, clone TMS00356, highly similar to Epithelial discoidin domain receptor 1 precursor (EC 2.7.1.112).
AF353182 - Homo sapiens discoidin domain receptor DDR1d (DDR1) mRNA, partial cds, alternatively spliced.
AF353183 - Homo sapiens discoidin domain receptor DDR1e (DDR1) mRNA, partial cds, alternatively spliced.

-  Other Names for This Gene
  Alternate Gene Symbols: A2ABM8, A2ABM8_HUMAN, AK130776, DADB-160J14.2-007, DAMA-342O2.2-007, DAQB-11J22.3-007, NM_001202522, NP_001189451
UCSC ID: uc011gux.1
RefSeq Accession: NM_001202522
Protein: A2ABM8

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK130776.1
exon count: 11CDS single in 3' UTR: no RNA size: 1593
ORF size: 1656CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3422.00frame shift in genome: no % Coverage: 92.84
has start codon: yes stop codon in genome: no # of Alignments: 5
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.