Human Gene DDR1 (uc011gup.2) Description and Page Index
  Description: Homo sapiens discoidin domain receptor tyrosine kinase 1 (DDR1), transcript variant 2, mRNA.
RefSeq Summary (NM_013993): Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,200,400-2,216,014 Size: 15,615 Total Exon Count: 19 Strand: +
Coding Region
   Position: chr6_mann_hap4:2,204,592-2,215,154 Size: 10,563 Coding Exon Count: 17 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: DDR1
CDC HuGE Published Literature: DDR1
Positive Disease Associations: Behcet Syndrome , Psoriasis , schizophrenia
Related Studies:
  1. Behcet Syndrome
    Elaine F Remmers et al. Nature genetics 2010, , Nature genetics. [PubMed 20622878]
  2. Psoriasis
    , , . [PubMed 0]
  3. Psoriasis
    , , . [PubMed 0]
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+  Comparative Toxicogenomics Database (CTD)
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+  Microarray Expression Data
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+  mRNA Secondary Structure of 3' and 5' UTRs
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000421 - Coagulation_fac_5/8-C_type_dom
IPR008979 - Galactose-bd-like
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_dom
IPR001245 - Ser-Thr/Tyr_kinase_cat_dom
IPR008266 - Tyr_kinase_AS
IPR020635 - Tyr_kinase_cat_dom
IPR002011 - Tyr_kinase_rcpt_2_CS

Pfam Domains:
PF00069 - Protein kinase domain
PF00754 - F5/8 type C domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
49785 - Galactose-binding domain-like
56112 - Protein kinase-like (PK-like)

Protein Data Bank (PDB) 3-D Structure

3ZOS
- X-ray Chimera

4AG4
- X-ray Chimera

4BKI
- X-ray Chimera
To conserve bandwidth, only the images from the first 3 structures are shown.
4BKJ - X-ray Chimera
Chimera help

ModBase Predicted Comparative 3D Structure on Q08345
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+  Orthologous Genes in Other Species
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+  Descriptions from all associated GenBank mRNAs
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-  Other Names for This Gene
  Alternate Gene Symbols: B5A975, B5A976, B7Z2K0, CAK, DDR1_HUMAN, EDDR1, NEP, NM_013993, NP_054699, NTRK4, PTK3A, Q08345, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2, RTK6, TRKE
UCSC ID: uc011gup.2
RefSeq Accession: NM_013993
Protein: Q08345 (aka DDR1_HUMAN