Human Gene MDC1 (uc011gug.1) Description and Page Index
  Description: Homo sapiens mediator of DNA-damage checkpoint 1 (MDC1), mRNA.
RefSeq Summary (NM_014641): The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D79992.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,027,745-2,033,095 Size: 5,351 Total Exon Count: 5 Strand: -
Coding Region
   Position: chr6_mann_hap4:2,027,746-2,031,046 Size: 3,301 Coding Exon Count: 4