Human Gene NRM (uc011gtz.3) Description and Page Index
  Description: Homo sapiens nurim (nuclear envelope membrane protein) (NRM), transcript variant 1, mRNA.
RefSeq Summary (NM_007243): The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine carboxymethyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:2,003,920-2,007,293 Size: 3,374 Total Exon Count: 5 Strand: -
Coding Region
   Position: chr6_mann_hap4:2,004,534-2,006,847 Size: 2,314 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
  ID: NRM_HUMAN
DESCRIPTION: RecName: Full=Nurim; AltName: Full=Nuclear envelope membrane protein; AltName: Full=Nuclear rim protein;
SUBCELLULAR LOCATION: Nucleus inner membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the nurim family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: NRM
CDC HuGE Published Literature: NRM

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -148.81352-0.423 Picture PostScript Text
3' UTR -189.16614-0.308 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009915 - NnrU

ModBase Predicted Comparative 3D Structure on Q8IXM6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  BC004509 - Homo sapiens nurim (nuclear envelope membrane protein), mRNA (cDNA clone IMAGE:3926898), partial cds.
AF143676 - Homo sapiens multispanning nuclear envelope membrane protein nurim (NRM29) mRNA, partial cds.
BC039865 - Homo sapiens nurim (nuclear envelope membrane protein), mRNA (cDNA clone MGC:49014 IMAGE:6043663), complete cds.
AK298152 - Homo sapiens cDNA FLJ51259 complete cds, highly similar to Homo sapiens nurim (nuclear envelope membrane protein) (NRM), mRNA.
AK075509 - Homo sapiens cDNA PSEC0207 fis, clone HEMBA1002981, highly similar to Homo sapiens nurim (nuclear envelope membrane protein) (NRM), mRNA.
BC021260 - Homo sapiens, clone IMAGE:4135057, mRNA, partial cds.
AY358411 - Homo sapiens clone DNA57702 NRM (UNQ555) mRNA, complete cds.
AK315190 - Homo sapiens cDNA, FLJ96172, Homo sapiens nurim (nuclear envelope membrane protein) (NRM), mRNA.
HQ448492 - Synthetic construct Homo sapiens clone IMAGE:100071924; CCSB011259_03 nurim (nuclear envelope membrane protein) (NRM) gene, encodes complete protein.
JQ798186 - Homo sapiens nuclear envelope membrane protein isoform b (NRM) mRNA, complete cds.
JQ798187 - Homo sapiens nuclear envelope membrane protein isoform c (NRM) mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: B0S7R0, B0S7R1, NM_007243, NP_009174, NRM29, NRM_HUMAN, Q5JP57, Q5JP58, Q5JP59, Q5JP60, Q8IXM6, Q8WU45, Q9BSX3, Q9UN92, uc011gtz.2, UNQ555/PRO1112
UCSC ID: uc011gtz.3
RefSeq Accession: NM_007243
Protein: Q8IXM6 (aka NRM_HUMAN