Human Gene DHX16 (uc011gtv.2) Description and Page Index
  Description: Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 16 (DHX16), transcript variant 2, mRNA.
RefSeq Summary (NM_001164239): DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:1,968,963-1,988,926 Size: 19,964 Total Exon Count: 20 Strand: -
Coding Region
   Position: chr6_mann_hap4:1,969,086-1,988,855 Size: 19,770 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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+  Comments and Description Text from UniProtKB
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-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: DHX16
CDC HuGE Published Literature: DHX16
Positive Disease Associations: Multiple Sclerosis
Related Studies:
  1. Multiple Sclerosis
    David A Hafler et al. The New England journal of medicine 2007, Risk alleles for multiple sclerosis identified by a genomewide study., The New England journal of medicine. [PubMed 17660530]
    Alleles of IL2RA and IL7RA and those in the HLA locus are identified as heritable risk factors for multiple sclerosis.

+  Comparative Toxicogenomics Database (CTD)
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-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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GNF Expression Atlas 1 Human Data on Affy U95 Chips

      
    
     
      
    
    
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+  mRNA Secondary Structure of 3' and 5' UTRs
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+  Protein Domain and Structure Information
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  AB011149 - Homo sapiens mRNA for KIAA0577 protein, partial cds.
AB001601 - Homo sapiens DBP2 mRNA for ATP-dependent RNA helicase #3, complete cds.
AF119860 - Homo sapiens PRO2014 mRNA, complete cds.
AK302721 - Homo sapiens cDNA FLJ53577 complete cds, highly similar to pre-mRNA-splicing factor ATP-dependentRNA helicase DHX16 (EC 3.6.1.-).
BC008825 - Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 16, mRNA (cDNA clone MGC:12779 IMAGE:4100320), complete cds.
BC009392 - Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 16, mRNA (cDNA clone MGC:15329 IMAGE:4136069), complete cds.
AK312264 - Homo sapiens cDNA, FLJ92560, highly similar to Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 16 (DHX16), mRNA.
DQ895906 - Synthetic construct Homo sapiens clone IMAGE:100010366; FLH189681.01L; RZPDo839H1164D DEAH (Asp-Glu-Ala-His) box polypeptide 16 (DHX16) gene, encodes complete protein.
AB385352 - Synthetic construct DNA, clone: pF1KA0577, Homo sapiens DHX16 gene for pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16, complete cds, without stop codon, in Flexi system.
CU679131 - Synthetic construct Homo sapiens gateway clone IMAGE:100017882 5' read DHX16 mRNA.
BC002789 - Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 16, mRNA (cDNA clone IMAGE:3618066), partial cds.

+  Biochemical and Signaling Pathways
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+  Other Names for This Gene
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-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001164239.1
exon count: 20CDS single in 3' UTR: no RNA size: 3156
ORF size: 2946CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5633.00frame shift in genome: no % Coverage: 99.49
has start codon: yes stop codon in genome: no # of Alignments: 8
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
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