Human Gene DHX16 (uc011gtv.2) Description and Page Index
  Description: Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 16 (DHX16), transcript variant 2, mRNA.
RefSeq Summary (NM_001164239): DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009].
Transcript (Including UTRs)
   Position: chr6_mann_hap4:1,968,963-1,988,926 Size: 19,964 Total Exon Count: 20 Strand: -
Coding Region
   Position: chr6_mann_hap4:1,969,086-1,988,855 Size: 19,770 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDMicroarray
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; EC=; AltName: Full=ATP-dependent RNA helicase #3; AltName: Full=DEAH-box protein 16;
FUNCTION: Probable ATP-binding RNA helicase involved in pre-mRNA splicing.
CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
INTERACTION: Q92620:DHX38; NbExp=2; IntAct=EBI-311446, EBI-1043041; Q92917:GPKOW; NbExp=2; IntAct=EBI-311446, EBI-746309; Q13435:SF3B2; NbExp=2; IntAct=EBI-311446, EBI-749111; Q9HCS7:XAB2; NbExp=2; IntAct=EBI-311446, EBI-295232;
SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily.
SIMILARITY: Contains 1 helicase ATP-binding domain.
SIMILARITY: Contains 1 helicase C-terminal domain.
SEQUENCE CAUTION: Sequence=BAA25503.2; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database: DHX16
CDC HuGE Published Literature: DHX16
Positive Disease Associations: Multiple Sclerosis
Related Studies:
  1. Multiple Sclerosis
    David A Hafler et al. The New England journal of medicine 2007, Risk alleles for multiple sclerosis identified by a genomewide study., The New England journal of medicine. [PubMed 17660530]
    Alleles of IL2RA and IL7RA and those in the HLA locus are identified as heritable risk factors for multiple sclerosis.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips


GNF Expression Atlas 1 Human Data on Affy U95 Chips


-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.8071-0.293 Picture PostScript Text
3' UTR -20.20123-0.164 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011545 - DNA/RNA_helicase_DEAD/DEAH_N
IPR002464 - DNA/RNA_helicase_DEAH_CS
IPR011709 - DUF1605
IPR007502 - Helicase-assoc_dom
IPR014001 - Helicase_ATP-bd
IPR001650 - Helicase_C
IPR027417 - P-loop_NTPase

Pfam Domains:
PF00271 - Helicase conserved C-terminal domain
PF04408 - Helicase associated domain (HA2)
PF07717 - Domain of unknown function (DUF1605)

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on O60231
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     

-  Descriptions from all associated GenBank mRNAs
  AB011149 - Homo sapiens mRNA for KIAA0577 protein, partial cds.
AB001601 - Homo sapiens DBP2 mRNA for ATP-dependent RNA helicase #3, complete cds.
AF119860 - Homo sapiens PRO2014 mRNA, complete cds.
AK302721 - Homo sapiens cDNA FLJ53577 complete cds, highly similar to pre-mRNA-splicing factor ATP-dependentRNA helicase DHX16 (EC 3.6.1.-).
BC008825 - Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 16, mRNA (cDNA clone MGC:12779 IMAGE:4100320), complete cds.
BC009392 - Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 16, mRNA (cDNA clone MGC:15329 IMAGE:4136069), complete cds.
AK312264 - Homo sapiens cDNA, FLJ92560, highly similar to Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 16 (DHX16), mRNA.
DQ895906 - Synthetic construct Homo sapiens clone IMAGE:100010366; FLH189681.01L; RZPDo839H1164D DEAH (Asp-Glu-Ala-His) box polypeptide 16 (DHX16) gene, encodes complete protein.
AB385352 - Synthetic construct DNA, clone: pF1KA0577, Homo sapiens DHX16 gene for pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16, complete cds, without stop codon, in Flexi system.
CU679131 - Synthetic construct Homo sapiens gateway clone IMAGE:100017882 5' read DHX16 mRNA.
BC002789 - Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 16, mRNA (cDNA clone IMAGE:3618066), partial cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03040 - Spliceosome

-  Other Names for This Gene
  Alternate Gene Symbols: DBP2, DDX16, DHX16_HUMAN, KIAA0577, NM_001164239, NP_001157711, O60231, O60322, Q5JP45, Q969X7, Q96QC1
UCSC ID: uc011gtv.2
RefSeq Accession: NM_001164239
Protein: O60231 (aka DHX16_HUMAN