Human Gene ATAT1 (uc011gtk.2) Description and Page Index
  Description: Homo sapiens alpha tubulin acetyltransferase 1 (ATAT1), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: chr6_mann_hap4:1,942,685-1,960,520 Size: 17,836 Total Exon Count: 10 Strand: +
Coding Region
   Position: chr6_mann_hap4:1,942,735-1,958,864 Size: 16,130 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarrayRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
  ID: ATAT_HUMAN
DESCRIPTION: RecName: Full=Alpha-tubulin N-acetyltransferase; Short=Alpha-TAT; Short=TAT; EC=2.3.1.108; AltName: Full=Acetyltransferase mec-17 homolog;
FUNCTION: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development.
CATALYTIC ACTIVITY: Acetyl-CoA + [alpha-tubulin]-L-lysine = CoA + [alpha-tubulin]-N(6)-acetyl-L-lysine.
SIMILARITY: Belongs to the acetyltransferase ATAT1 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -18.8050-0.376 Picture PostScript Text
3' UTR -566.011656-0.342 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016181 - Acyl_CoA_acyltransferase
IPR007965 - Alpha-TAT

Pfam Domains:
PF05301 - Protein of unknown function (DUF738)

Protein Data Bank (PDB) 3-D Structure

3VWD
- X-ray Chimera

3VWE
- X-ray Chimera

4B5O
- X-ray Chimera
To conserve bandwidth, only the images from the first 3 structures are shown.
4B5P - X-ray Chimera 4GS4 - X-ray Chimera
Chimera help

ModBase Predicted Comparative 3D Structure on Q5SQI0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Jackson LabRGD    
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  BC006105 - Homo sapiens chromosome 6 open reading frame 134, mRNA (cDNA clone MGC:12938 IMAGE:2820493), complete cds.
AK023220 - Homo sapiens cDNA FLJ13158 fis, clone NT2RP3003552.
AK298743 - Homo sapiens cDNA FLJ60791 complete cds.
AK225107 - Homo sapiens mRNA for Hypothetical protein DKFZp547J097 variant, clone: CBL01641.
AB075512 - Homo sapiens neuroblastoma cDNA, clone:Nbla00487, full insert sequence.
BC047303 - Homo sapiens chromosome 6 open reading frame 134, mRNA (cDNA clone MGC:54124 IMAGE:4914615), complete cds.
AL833858 - Homo sapiens mRNA; cDNA DKFZp547J097 (from clone DKFZp547J097).
BC025755 - Homo sapiens chromosome 6 open reading frame 134, mRNA (cDNA clone IMAGE:5202281), complete cds.
AK297661 - Homo sapiens cDNA FLJ55872 complete cds.
CU693052 - Synthetic construct Homo sapiens gateway clone IMAGE:100020610 5' read C6orf134 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: A2AB28, AK023220, ATAT_HUMAN, C6orf134, MEC17, Nbla00487, NM_001031722, NP_001026892, Q3LIB0, Q5JP39, Q5JP40, Q5JP42, Q5SQI0, Q5SQI1, Q5SU03, Q86X42, Q8NDK9, Q9BRS1, Q9H8X5
UCSC ID: uc011gtk.2
RefSeq Accession: NM_001031722
Protein: Q5SQI0 (aka ATAT_HUMAN